A5063337001- MicroRNA in disease regulation
- Circular RNAs in diseases
- Palliative Care and End-of-Life Issues
- Healthcare Decision-Making and Restraints
- Cardiac Arrest and Resuscitation
- Cancer-related molecular mechanisms research
- Angiogenesis and VEGF in Cancer
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Disaster Response and Management
- Mechanical Circulatory Support Devices
- Ethics and Legal Issues in Pediatric Healthcare
- Atherosclerosis and Cardiovascular Diseases
- COVID-19 and Mental Health
- Ethics in medical practice
- Cell Adhesion Molecules Research
- Family and Patient Care in Intensive Care Units
- Sepsis Diagnosis and Treatment
- Cardiac Fibrosis and Remodeling
- Medical and Health Sciences Research
- Blood Pressure and Hypertension Studies
- Trauma and Emergency Care Studies
- SARS-CoV-2 and COVID-19 Research
- Telomeres, Telomerase, and Senescence
- Healthcare cost, quality, practices
University Hospital in Halle
2019-2024
Martin Luther University Halle-Wittenberg
2019-2024
Chonnam National University Hwasun Hospital
2023
Kemerovo State University
2023
Kyungpook National University
2023
Luther University
2021
Medizinische Hochschule Hannover
2013-2020
Harvard University
2020
Brigham and Women's Hospital
2012-2020
Universidad de Granada
2016
High-risk acute pulmonary embolism (PE) is a life-threatening condition necessitating hemodynamic stabilization and rapid restoration of perfusion. In this context, evidence regarding the benefit advanced circulatory support recanalization strategies still limited. observational study, we assessed data 1060 patients treated for high-risk PE with 991 being included in target trial emulation to investigate all-cause in-hospital mortality estimates different treatment strategies. The four...
MicroRNA (miR)-92a is an important regulator of endothelial proliferation and angiogenesis after ischaemia, but the effects miR-92a on re-endothelialization neointimal lesion formation vascular injury remain elusive. We tested lowering levels using specific locked nucleic acid (LNA)-based antimiRs as well endothelial-specific knock out wire-induced femoral artery in mice.MiR-92a was significantly up-regulated lesions following injury. Pre-miR-92a overexpression resulted repression direct...
Post-acute sequelae of COVID-19 (PASC) are long-term consequences SARS-CoV-2 infection that can substantially impair the quality life. Underlying mechanisms ranging from persistent viruses to innate and adaptive immune dysregulation have been discussed. Here, we profiled plasma 181 individuals cohort study for digital health research in Germany (DigiHero), including after mild moderate with or without PASC uninfected controls. We focused on soluble factors related monocyte/macrophage biology...
BACKGROUND: Intermittent fasting has shown positive effects on numerous cardiovascular risk factors. The INTERFAST-MI trial (Intermittent Fasting in Myocardial Infarction) been designed to study the of intermittent cardiac function after STEM (ST-segment–elevation myocardial infarction) and feasibility future multicenter trials. METHODS: was a prospective, randomized, controlled, nonblinded, single-center investigator-initiated trial. From October 1, 2020, July 15, 2022, 48 patients were...
The chemokine receptor CXCR4 is a promising target for molecular imaging of CXCR4+ cell types, e.g. inflammatory cells, in cardiovascular diseases. We speculated that specific ligand, [68Ga]pentixafor, along with novel techniques motion correction, would facilitate the vivo characterization expression small culprit and nonculprit coronary atherosclerotic lesions after acute myocardial infarction by motion-corrected targeted PET/CT.CXCR4 was analysed ex separately obtained arterial wall...
Renal sympathetic denervation (RDN) has been shown to lower arterial blood pressure both in the presence and absence of antihypertensive medication an observation period up 3 years. However, long-term results beyond years are scarcely reported.We performed a follow-up on patients who were previously enrolled local renal registry underwent radiofrequency RDN with Symplicity Flex® system between 2011 2014. The assessed evaluate their function by performing 24-hour ambulatory measurement...
In parasite and viral infections, aberrant B cell responses can suppress germinal center reactions thereby blunting long-lived memory may provoke immunopathology including autoimmunity. Using COVID-19 as model, we set out to identify serological, cellular, transcriptomic imprints of pathological linked autoreactive cells at single-cell resolution. We show that excessive plasmablast expansions are prognostically adverse correlate with autoantibody production but do not hinder the formation...
Dedifferentiation, migration, and proliferation of resident vascular smooth muscle cells (SMCs) are key components neointima formation after injury. Activation signal transducer activator transcription-3 (STAT3) is suggested to be critically involved in this process, but the complex regulation STAT3-dependent genes functional significance inhibiting pathway during development proliferative diseases remain elusive. In study, we demonstrate that STAT3 was activated neointimal lesions following...
Abstract Aims Adventitial cells have been suggested to contribute neointima formation, but the functional relevance and responsible signalling pathways are largely unknown. Sonic hedgehog (Shh) is a regulator of vasculogenesis promotes angiogenesis in adult. Methods results Here we show that proliferation vascular smooth muscle (SMC) after wire-induced injury C57BL/6 mice preceded by adventitial fibroblasts. Simultaneously, expression Shh its downstream protein smoothened (SMO) were robustly...
Background The novel nonsteroidal mineralocorticoid receptor (MR) antagonist finerenone holds promise to be safe and efficient in the treatment of patients with heart failure and/or chronic kidney disease. However, its effects on vascular function remain elusive. Purpose aim this study was determine functional effect selective MR antagonism by cells vitro remodeling following acute injury vivo. Methods results In vitro, dose-dependently reduced aldosterone-induced smooth muscle cell (SMC)...
Abstract Monocytes and macrophages contribute to pathogenesis of various inflammatory diseases, including auto-inflammatory cancer, sepsis, or atherosclerosis. They do so by production cytokines, the central regulators inflammation. Isoprenylation small G-proteins is involved in regulation some cytokines. Statins possibly affect isoprenylation-dependent cytokine monocytes differentially. Thus, we compared statin-dependent lipopolysaccharide (LPS)-stimulated freshly isolated human derived...
Ehegatten sind seit Anfang 2023 dazu berechtigt, sich bei Einwilligungsunfähigkeit des jeweils anderen in Angelegenheiten der Gesundheitssorge zu vertreten. Damit geht die Pflicht behandelnden Arztes einher, bescheinigen, dass Voraussetzungen Ehegattennotvertretungsrechts tatsächlich erfüllt sind. Das neue Gesetz wirft einige Fragen auf, wie im folgenden Artikel erläutert wird.
Abstract Circulating endothelial cells (CEC) are arising as biomarkers for vascular diseases. However, whether they can be utilized markers of cell (EC) senescence in vivo remains unknown. Here, we present a protocol to isolate circulating characterization their senescent signature. Further, characterize different models EC induction vitro and show similar patterns being upregulated CECs aged patients compared young volunteers. Replication-(ageing), etoposide-(DNA damage) angiotensin...
A considerable fraction of B cells recognize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with germline-encoded elements their cell receptor, resulting in the production neutralizing and nonneutralizing antibodies. We found that antibody sequences from different discovery cohorts shared biochemical properties could be retrieved across validation cohorts, confirming stereotyped character this naive response disease 2019 (COVID-19). While were independently severity, line...
Sepsis is as a life-threatening organ dysfunction caused by dysregulated host response to an infection. The mortality of sepsis and particular septic shock very high. Treatment mostly focuses on infection control but specific intervention that targets the underlying pathological lacking present time. investigators hypothesize early therapeutic plasma exchange (TPE) will dampen maladaptive removing injurious mediators thereby limiting improving survival in patients with shock. Although small...