A5025672693- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Diabetes Management and Research
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Coronary Interventions and Diagnostics
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Bariatric Surgery and Outcomes
- Cardiac electrophysiology and arrhythmias
- Blood groups and transfusion
- Cardiac Valve Diseases and Treatments
- Sepsis Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Diabetes Management and Education
- Cardiovascular Effects of Exercise
- Trauma and Emergency Care Studies
- Takotsubo Cardiomyopathy and Associated Phenomena
- Erythropoietin and Anemia Treatment
- Surgical Simulation and Training
Leipzig Heart Institute
2014-2025
Leipzig University
2018-2025
German Centre for Cardiovascular Research
2018-2025
University of Lübeck
2021
Klinik und Poliklinik für Nuklearmedizin
2019
University Hospital Leipzig
2019
Deutsches Herzzentrum der Charité
2018-2019
Universitätsklinikum Aachen
2013
Diabetesinstitut Heidelberg
2000
University of Florida Health Science Center
1991
Extracorporeal life support (ECLS) is increasingly used in the treatment of infarct-related cardiogenic shock despite a lack evidence regarding its effect on mortality. Download PDF Research Summary. In this multicenter trial, patients with acute myocardial infarction complicated by for whom early revascularization was planned were randomly assigned to receive ECLS plus usual medical (ECLS group) or alone (control group). The primary outcome death from any cause at 30 days. Safety outcomes...
Myocardial infarction is a frequent cause of out-of-hospital cardiac arrest. However, the benefits early coronary angiography and revascularization in resuscitated patients without electrocardiographic evidence ST-segment elevation are unclear.In this multicenter trial, we randomly assigned 554 with successfully arrest possible origin to undergo either immediate (immediate-angiography group) or initial intensive care assessment delayed selective (delayed-angiography group). All had no on...
Abstract Background Cardiogenic shock (CS) complicating acute myocardial infarction (AMI) still reaches excessively high mortality rates. This analysis is aimed to develop a new easily applicable biomarker-based risk score. Methods and results A score for 30-day was developed from 458 patients with CS AMI included in the randomized CULPRIT-SHOCK trial. The selection of relevant predictors coefficient estimation prognostic model were performed by penalized multivariate logistic regression...
The proportion of patients with multivessel coronary artery disease in individuals experiencing acute syndrome (ACS) varies based on age and ACS subtype. In ST-segment elevation myocardial infarction (STEMI) without cardiogenic shock, the prognostic benefit complete revascularization has been demonstrated by several randomized trials meta-analyses, leading to a strong guideline recommendation. However, similar data are lacking for (NSTE-ACS). Non-randomized suggesting from non-ST-segment...
Extracorporeal life support (ECLS) has been increasingly used in the treatment of severe infarct-related cardiogenic shock last decade. The randomised ECLS-SHOCK trial demonstrated no benefit early routine use on 30-day all-cause death. We herein present mid-term results. At 1-year follow-up, there were significant differences or cardiovascular mortality, neurologic outcome, recurrent myocardial infarction, repeat revascularisation and rehospitalisations for heart failure between ECLS usual...
Cardiogenic shock (CS) is a life-threatening complication of acute coronary syndromes (ACS). Early revascularization with treating the culprit lesion improves survival. Nevertheless, impact access site (femoral vs. radial) on outcomes in infarct-related CS also conjunction extracorporeal life support (ECLS) remains unclear. This subanalysis ECLS-SHOCK trial included patients treated or without ECLS, divided into femoral and radial groups. The primary endpoint was 30-day mortality. Secondary...
Used 24-hr recall interviews to assess adherence in a sample of seventy-eight 6- 19-year-olds with insulin-dependent diabetes mellitus over 3-month period. Thirteen measures were quantified and grouped into six factors (Injection, Exercise, Diet Type, Testing/Eating Frequency, Calories Consumed, Concentrated Sweets). Prevailing glucose levels 2- interval indexed by glycosylated hemoglobin A1c (HA1c) serum protein (GSP) assays. Fasting triglycerides (TRIG) total cholesterol (CHOL) assays used...
Conducted 24-hr recall interviews concerning daily diabetes management with seventy-eight 6- to 19-year-old patients and their parents. Patients parents were interviewed independently nine times over 3 months. Data obtained used construct 13 adherence measures. All measures yielded statistically significant estimates of parent-child concordance. Parent-child agreement was higher for weekday versus weekend behaviors when based on three interviews. For the sample as a whole, concordance...
Twenty-five adolescent campers with insulin-dependent diabetes mellitus (IDDM) completed a Symptom Rating Checklist and estimated their blood glucose (BG) immediately before having BG assessed four times daily for 11 days. Consistent relationships between symptoms were not identified when the data analyzed group as whole. However, each camper's separately, 23 of 25 adolescents had at least one significant glycemia-symptom (G-S) correlation. Each camper seemed to have unique G-S pattern; only...
The exact pathophysiology of Takotsubo syndrome (TTS) remains not fully understood with most studies focussing on ventricular pathology. Since atrial involvement may have a significant role, we assessed the diagnostic and prognostic potential cardiovascular magnetic resonance feature tracking (CMR-FT) in TTS.This multicentre study recruited 152 TTS patients who underwent CMR average within 3 days after hospitalization. Reservoir [total strain εs peak positive rate (SR) SRs], conduit (passive...
Myocardial infarction is a frequent cause of out-of-hospital cardiac arrest (OHCA). The long-term effect early coronary angiography on patients with OHCA possible trigger but no ST-segment elevation remains unclear.
In patients with left-sided native-valve infective endocarditis (IE), the risk of embolism is increased a vegetation size ≥10 mm. For this reason-according to guidelines-surgery may be considered in isolated large vegetations (without any other indication for surgery). However, value surgery patient subset has never been systematically studied.We hypothesized that superior medical therapy terms clinical outcome aforementioned patients.All who presented at our institution between January 2000...
Abstract Aims The optimal revascularization strategy for patients with acute myocardial infarction (AMI), cardiogenic shock (CS), and multivessel disease remains controversial. CULPRIT-SHOCK trial compared culprit lesion–only vs. immediate percutaneous coronary intervention (PCI), providing important data but leaving efficacy questions unresolved. To address lingering uncertainties gain deeper insights, we performed a Bayesian reanalysis of the data. Methods results We conducted re-analysis...