A5064309744- Antiplatelet Therapy and Cardiovascular Diseases
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Lipoproteins and Cardiovascular Health
- Cardiac Valve Diseases and Treatments
- Peripheral Artery Disease Management
- Cardiovascular Function and Risk Factors
- Inflammatory mediators and NSAID effects
- Platelet Disorders and Treatments
- Prostate Cancer Treatment and Research
- Cardiac Arrhythmias and Treatments
- Angiogenesis and VEGF in Cancer
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac, Anesthesia and Surgical Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Diabetes Treatment and Management
- Cardiac and Coronary Surgery Techniques
- Cancer Diagnosis and Treatment
- Vascular Procedures and Complications
- NF-κB Signaling Pathways
- Extracellular vesicles in disease
- Cardiac Ischemia and Reperfusion
Universitäts-Herzzentrum Freiburg-Bad Krozingen
2015-2024
University of Freiburg
2012-2024
University Medical Center Freiburg
2023-2024
Johannes Gutenberg University Mainz
2023
Friedrich-Alexander-Universität Erlangen-Nürnberg
2011
Verband Forschender Arzneimittelhersteller
2010
Heidelberg University
2010
University Hospital of Zurich
2010
Tulane University
2004-2007
BackgroundIn patients receiving aspirin, the optimal duration of clopidogrel therapy after drug-eluting stent (DES) implantation remains unclear.
This study was designed to assess whether intracoronary application of adipose tissue-derived stem cells (ADSCs) compared with bone marrow-derived (BMSCs) and control could improve cardiac function after 30 days in a porcine acute myocardial infarction/reperfusion model.An transmural infarction induced by inflating an angioplasty balloon for 180 min the mid-left anterior descending artery. Two million cultured autologous were injected through central lumen inflated catheter. Analysis...
In patients with ST-segment elevation myocardial infarction (STEMI) multivessel coronary artery disease, the time at which complete revascularization of nonculprit lesions should be performed remains unknown. Download a PDF Research Summary. We an international, open-label, randomized, noninferiority trial 37 sites in Europe. Patients hemodynamically stable condition who had STEMI and disease were randomly assigned to undergo immediate percutaneous intervention (PCI; group) or PCI culprit...
BackgroundStent thrombosis (ST) is a rare but serious complication following percutaneous coronary intervention. Analysis of thrombus composition from patients undergoing catheter thrombectomy may provide important insights into the pathological processes leading to formation. We performed large-scale multicentre study evaluate specimens in with ST across Europe.
Background— Recently published data indicate that the paraoxonase-1 ( PON1 ) Q192R genotype—and not as previously shown activity of cytochrome P450 (CYP) 2C19—is major determinant metabolic bioactivation clopidogrel and thereby variability antiplatelet effect clopidogrel. We sought to investigate whether gene polymorphism affects platelet reactivity in patients undergoing elective coronary stent placement. Methods Results— The study included 760 consecutive placement after loading with 600...
Although a 140 U/kg dose of unfractionated heparin (UFH) was comparable with bivalirudin in terms net clinical outcome the Intracoronary Stenting and Antithrombotic Regimen: Rapid Early Action for Coronary Treatment (ISAR-REACT) 3 trial, it associated higher risk bleeding. We designed this study to assess whether reduction UFH from 100 is improved outcome.A total 2505 biomarker negative patients undergoing percutaneous coronary intervention (PCI) after clopidogrel pre-treatment received...
Data on the comparative efficacy and safety of ticagrelor versus prasugrel in patients with ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention are limited. We assessed a head-to-head comparison intervention.In this prespecified subgroup analysis, we included 1653 randomized to receive or setting ISAR REACT-5 trial (Intracoronary Stenting Antithrombotic Regimen: Rapid Early Action for Coronary Treatment 5). The end point was incidence death,...
Summary Early studies suggested interactions between statins and clopidogrel. Based on the outcome platelet data, there is now huge evidence of no 75 to 300 mg clopidogrel; however, data with 600-mg loading are lacking. In a pre-specified analysis EXCELSIOR cohort, we investigated interaction statins, especially cytochrome P4503A4-metabolized atorvastatin simvastatin, antiplatelet effects dose We analyzed 1,395 patients scheduled for coronary angiography (CA). Patients received clopidogrel...
Previously, we reported that the nine-month angiographic result after treatment of coronary bifurcation lesions with provisional T-stenting was not significantly different from routine T-stenting. To compare long-term clinical outcomes two stenting strategies, extended follow-up our study on stenting.One hundred and one patients had been randomly assigned to 101 T-stenting, using sirolimus-eluting stents. We performed complete five-year follow-up. The primary efficacy endpoint incidence...
Summary Reticulated platelets are associated with impaired antiplatelet response to thienopyridines. It is uncertain whether this interaction caused by a decreased drug exposure due high platelet turnover reflected elevated levels of reticulated or intrinsic properties platelets. This study sought investigate if the impact on early thienopyridines mainly as previously suggested. Elective patients undergoing coronary intervention were randomised loading clopidogrel 600 mg prasugrel 60...
This study investigated the contemporary incidence and predictors of radial artery occlusion as well effectiveness antithrombotic treatment for following transradial coronary angiography.
Myocardial infarction is a frequent cause of out-of-hospital cardiac arrest (OHCA). The long-term effect early coronary angiography on patients with OHCA possible trigger but no ST-segment elevation remains unclear.