A5037741543- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- ECG Monitoring and Analysis
- Cardiac Imaging and Diagnostics
- Ion channel regulation and function
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular Effects of Exercise
- Advanced MRI Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Radiation Dose and Imaging
- Electrostatic Discharge in Electronics
- Infective Endocarditis Diagnosis and Management
- Cardiac tumors and thrombi
- Pulmonary Hypertension Research and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- Microbial Inactivation Methods
- Central Venous Catheters and Hemodialysis
- Heart Failure Treatment and Management
- Cerebrovascular and Carotid Artery Diseases
Universitäts-Herzzentrum Freiburg-Bad Krozingen
2016-2025
University of Freiburg
1998-2025
University Medical Center Freiburg
2021-2025
Hôpital Cardiologique du Haut-Lévêque
2002-2016
The Arrhythmia Institute
2014
Centre Hospitalier Universitaire de Grenoble
2005-2006
Centre Hospitalier Universitaire de Limoges
2006
Université de Bordeaux
2004
Institute of Clinical and Experimental Medicine
2002
Queen Elizabeth Hospital Birmingham
2002
Current guidelines recommend pulmonary-vein isolation by means of catheter ablation as treatment for drug-refractory paroxysmal atrial fibrillation. Radiofrequency is the most common method, and cryoballoon second frequently used technology.We conducted a multicenter, randomized trial to determine whether was noninferior radiofrequency in symptomatic patients with The primary efficacy end point time-to-event analysis first documented clinical failure (recurrence fibrillation, occurrence...
Background— Ventricular fibrillation is the main mechanism of sudden cardiac death. The feasibility eliminating recurrent episodes by catheter ablation has not been reported. Methods and Results— Twenty-seven patients without known heart disease (13 men, 14 women, 41±14 years age) were studied after being resuscitated from (10±12) primary idiopathic ventricular fibrillation; 23 had received a defibrillator. first initiating beat an identical electrocardiographic morphology coupling interval...
Pulmonary vein (PV) isolation is a promising new treatment for atrial fibrillation (AF). We hypothesized that of large areas around both ipsilateral PVs with verification conduction block more effective than the each individual PV.A total 110 patients, 67 paroxysmal AF and 43 persistent AF, were randomly assigned to undergo either PV or PVs. The was an electrophysiologically guided, ostial segmental ablation 64-pole basket catheter 20-pole circular mapping (group I). Isolation performed 2...
The primary safety and efficacy endpoints of the randomized FIRE AND ICE trial have recently demonstrated non-inferiority cryoballoon vs. radiofrequency current (RFC) catheter ablation in patients with drug-refractory symptomatic paroxysmal atrial fibrillation (AF). aim study was to assess outcome parameters that are important for daily clinical management using key secondary analyses. Specifically, reinterventions, rehospitalizations, quality-of-life were examined this RFC ablation.Patients...
Background— Complex-fractionated atrial electrograms and fibrosis are associated with maintenance of persistent fibrillation (AF). We hypothesized that pulmonary vein isolation (PVI) plus ablation selective low-voltage sites may be more successful than PVI only. Methods Results— A total 85 consecutive patients AF underwent high-density voltage mapping, PVI, at areas (LVA<0.5 mV in AF) electric activity lasting >70% cycle length on a single electrode (fractionated activity) or multiple...
Abstract Aims Pulsed field ablation (PFA) is a novel atrial fibrillation (AF) modality that has demonstrated preferential tissue ablation, including no oesophageal damage, in first-in-human clinical trials. In the MANIFEST-PF survey, we investigated ‘real world’ performance of only approved PFA catheter, acute effectiveness and safety—in particular, rare effects other unforeseen PFA-related complications. Methods results This retrospective survey included all 24 centres using pentaspline...
Pulsed field ablation is a novel nonthermal cardiac modality using ultra-rapid electrical pulses to cause cell death by mechanism of irreversible electroporation. Unlike the traditional energy sources, pulsed has demonstrated significant preferentiality myocardial tissue ablation, and thus avoids certain thermally mediated complications. However, its safety effectiveness remain unknown in usual clinical care.MANIFEST-PF (Multi-National Survey on Methods, Efficacy, Safety Post-Approval...
Background: Optimal treatment of patients with persistent atrial fibrillation (AF) and heart failure (HF) reduced left ventricular ejection fraction (LVEF) an indication for internal defibrillator therapy is controversial. Methods: Patients persistent/longstanding AF LVEF ≤35% were randomly allocated to catheter ablation or best medical (BMT). The primary study end point was the absolute increase in from baseline at 1 year. Secondary points included 6-minute walk test, quality-of-life,...
Background: The FIRE AND ICE trial assessed efficacy and safety of pulmonary vein (PV) isolation using cryoballoon versus radiofrequency current (RFC) ablation in patients with drug refractory, symptomatic, paroxysmal atrial fibrillation (AF). purpose the study was to assess index lesion durability as well reablation strategy outcomes undergoing a procedure. Methods: Patients procedures during were retrospectively consented enrolled at 13 centers. first for each patient included analysis....
Abstract Pulsed field ablation (PFA) is an emerging technology for the treatment of atrial fibrillation (AF), which pre-clinical and early-stage clinical data are suggestive some degree preferentiality to myocardial tissue without damage adjacent structures. Here in MANIFEST-17K study we assessed safety PFA by studying post-approval use this modality. Of 116 centers performing with a pentaspline catheter, were received from 106 (91.4% participation) regarding 17,642 patients undergoing (mean...
Initial clinical studies of pulsed field ablation (PFA) to treat atrial fibrillation (AF) indicated a >90% durability rate pulmonary vein isolation (PVI). However, these were largely conducted in single centers and involved limited number operators. The electrophysiological findings outcomes patients undergoing repeat after an initial PF for AF are incompletely understood. In the MANIFEST-REDO study, we investigated who underwent due recurrence - or tachycardia (AT) following first-ever PVI...
Background— We report on 4 patients (aged 57 to 77 years; 3 men) who developed drug-refractory, repetitive ventricular tachyarrhythmias after acute myocardial infarction (MI). All episodes of arrhythmias were triggered by monomorphic premature beats (VPBs) with a right bundle-branch block morphology (RBBB). Methods and Results— Left (LV) mapping was performed attempt radiofrequency (RF) ablation the triggering VPBs. Activation clinical VPBs demonstrated earliest activation in anteromedial LV...
We assessed the mode of reinitiation atrial fibrillation (AF) after cardioversion and efficacy ablating these foci in patients with chronic AF.Fifteen patients, 7 structural heart disease, underwent mapping catheter ablation drug-resistant AF documented to be persistent for 5 +/- 4 months. In all was followed by documentation P on T ectopy early recurrence, which allowed reinitiating trigger or source ectopy. Radiofrequency (RF) performed at pulmonary vein (PV) ostia using a target...
The endogenous nucleoside adenosine is an important intermediate in cellular metabolism, a regulator of function many organ systems, and pharmacologic agent with potent electrophysiologic effects. We studied the effects on activation pulmonary veins (PVs) after successful ostial isolation patients atrial fibrillation (AF).Twenty-nine (21 male; mean age 54 +/- 10 years) refractory highly symptomatic persistent (n = 9) or paroxysmal 20) AF were included study. PV was performed using...
Background— Early recurrences (ERs) of atrial tachyarrhythmia are common after catheter ablation fibrillation. A 3-month blanking period is recommended by current guidelines. This study sought to investigate the significance ER during first 3 months post in predicting late and determine whether it varies according timing. Methods Results— total 401 patients with paroxysmal fibrillation undergoing pulmonary vein isolation were followed for 12 transtelephonic monitoring ADVICE (Adenosine...
Mechanisms of Pulmonary Vein Reconnection After Radiofrequency Ablation Atrial Fibrillation Introduction vein reconnection (PVR) is an important cause AF recurrence after ablation. With the advent force sensing catheters, catheter–tissue contact can be determined quantitatively. Since (CF) plays a major role in determining characteristics RF lesion, we prospectively assessed mechanisms PVR with regard to catheter‐contact and lesion distances patients undergoing Methods Results Forty...
Data on predictors of long-term clinical outcomes after catheter ablation atrial fibrillation (AF) are limited. We sought to assess the association baseline covariates with in 750 patients drug-refractory paroxysmal AF enrolled FIRE AND ICE.In a 2-part analysis, univariate and multivariable Cox regression models were first used identify patient characteristics predictive efficacy determined by end points (1) arrhythmia recurrence (primary failure), (2) cardiovascular rehospitalization, (3)...