A5050723362- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- Cardiovascular Disease and Adiposity
- Protease and Inhibitor Mechanisms
- Electrospun Nanofibers in Biomedical Applications
- Cell Adhesion Molecules Research
- Venous Thromboembolism Diagnosis and Management
- Cardiac Valve Diseases and Treatments
- Aortic aneurysm repair treatments
- Lipoproteins and Cardiovascular Health
- Health Systems, Economic Evaluations, Quality of Life
- Atherosclerosis and Cardiovascular Diseases
- Cardiac electrophysiology and arrhythmias
- Blood Coagulation and Thrombosis Mechanisms
- Atrial Fibrillation Management and Outcomes
- Infectious Aortic and Vascular Conditions
- CRISPR and Genetic Engineering
- Mechanical Circulatory Support Devices
- Cardiovascular Health and Disease Prevention
- Peripheral Artery Disease Management
Université Paris Cité
2014-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Hôpital Bichat-Claude-Bernard
2016-2025
Alliance nationale pour les sciences de la vie et de la santé
2016-2025
Digital Research Alliance of Canada
2025
Inserm
2014-2024
Sorbonne Paris Cité
2011-2022
Laboratoire de Recherche Vasculaire Translationnelle
2016-2022
Clinical Trial Investigators
2022
Hôpitaux Universitaires Paris-Ouest
2021
In patients with ST-segment elevation myocardial infarction (STEMI), percutaneous coronary intervention (PCI) of the culprit lesion reduces risk cardiovascular death or infarction. Whether PCI nonculprit lesions further such events is unclear.
Background— Few data are available on the impact of heart failure (HF) across all types acute coronary syndromes (ACS). Methods and Results— The Global Registry Acute Coronary Events (GRACE) is a prospective study patients hospitalized with ACS. Data from 16 166 were analyzed: 13 707 without prior HF or cardiogenic shock at presentation identified. Of these, 1778 (13%) had an admission diagnosis (Killip class II III). was associated marked increase in mortality rates during hospitalization...
Stent thrombosis (ST) is a serious complication following coronary stenting. Intravascular optical coherence tomography (OCT) may provide insights into mechanistic processes leading to ST. We performed prospective, multicenter study evaluate OCT findings in patients with ST.Consecutive presenting ST were prospectively enrolled registry by using centralized telephone registration system. After angiographic confirmation of ST, imaging the culprit vessel was frequency domain OCT. Clinical data...
To prospectively determine whether early first-pass perfusion and delayed-enhancement magnetic resonance (MR) imaging sequences can enable differentiation of acute myocardial infarction (AMI) from myocarditis in patients with chest pain.All examinations were performed according to guidelines the institutional board on medical ethics clinical investigation after informed patient consent was obtained. Fifty-five a presentation suggestive but not typical AMI examined. At final diagnosis, 31 had...
We examined development risks for new cancer drugs. For the full study period, estimated clinical approval success rate compounds was 13.4% (9.9% first half of 19.8% second half). Small molecules had a somewhat higher than did large (14.3 vs. 11.5%). Compounds studied solely in hematologic indications markedly rates only solid tumor (36.0 9.8%). The first, second, and third pursued 9.0, 8.2, 6.9%, respectively. Success were found to be highly dependent on or failure indication (54.9 42.4%,...
Background and Purpose— There is an overlap between stroke coronary heart disease, but the exact prevalence of artery disease in patients with nonfatal cerebral infarction unclear, particularly when there no known history disease. Methods— We consecutively enrolled 405 presenting acute documented by neuroimaging who underwent carotid femoral artery, thoracic, abdominal aorta ultrasound examinations. Of 342 315 angiography a median 8 days (interquartile range, 6–11) after onset. Results—...
BackgroundStent thrombosis (ST) is a rare but serious complication following percutaneous coronary intervention. Analysis of thrombus composition from patients undergoing catheter thrombectomy may provide important insights into the pathological processes leading to formation. We performed large-scale multicentre study evaluate specimens in with ST across Europe.
Macrophages play a key role in atherosclerotic plaque rupture. The iodine-based contrast agent N1177 accumulates macrophages, allowing for their detection with CT. In this study, we tested whether the intensity of enhancement detected CT aortic wall rabbits injected correlated inflammatory activity evaluated <sup>18</sup>F-FDG PET/CT and macrophage density on histology. <b>Methods:</b> Atherosclerotic plaques were induced aorta New Zealand White (<i>n</i> = 7) by repeated balloon injury (4...
BACKGROUND Previous investigations in live animals convincingly established that arterial gene transfer, while feasible, was compromised by a low transfection efficiency. More recent studies have shown efficiency may be substantially augmented the use of recombinant adenoviral vectors. Most vivo transfections reported to date, however, used direct (operative) administration vector. Clinical applications transfer (such as prevention restenosis), would require local percutaneous delivery...
Objective— The immune receptor homologue glycoprotein VI (GPVI)/FcR γ chain complex is primarily responsible for platelet activation by collagen. There growing evidence that optimal binding of GPVI to collagen depends on the assembly dimers. valence resting platelets needs be clearly established because avidity would greater if constitutively expressed as a dimer than monomer. Methods and Results— Using monoclonal antibody (9E18) preferentially binds dimers, we found was maintained in...
Abstract Aims The rapid endothelialization of bare metal stents (BMS) is counterbalanced by inflammation-induced neointimal growth. Drug-eluting (DES) prevent leukocyte activation but impair endothelialization, delaying effective device integration into arterial walls. Previously, we have shown that engaging the vascular CD31 co-receptor crucial for endothelial and homeostasis healing. Furthermore, a soluble synthetic peptide (known as P8RI) acts like agonist. aim this study was to evaluate...
Article1 June 1938SUBACUTE BACTERIAL ENDOCARDITIS FOLLOWING THE REMOVAL OF TEETH OR TONSILSL. FELDMAN, M.D., I. M. TRACE, F.A.C.P.L. M.D.Search for more papers by this author, F.A.C.P.Search authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-12-2124 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt has been the opinion of many investigators that upper respiratory passages...
Background —Intimal hyperplasia after stent implantation is the main cause of in-stent restenosis. Activated monocytes play a key role in intimal growth. The anti-inflammatory cytokine interleukin-10 (IL-10) potent monocyte deactivator, endogenously produced atherosclerotic plaque. We tested hypothesis that exogenous IL-10 may limit postangioplasty balloon angioplasty or stenting. Methods and Results —Hypercholesterolemic rabbits were treated with recombinant human (rhuIL-10) for 3 days 28...
Objective: Monocyte adhesion to endothelial cells and subsequent secretion of matrix metalloproteinases (MMPs) by activated macrophages are key events in arteriosclerosis restenosis. We tested the hypothesis that interleukin-10 (IL-10), a potent anti-inflammatory cytokine, inhibits monocyte-endothelial cell interactions. Methods: The effect IL-10 on monocyte/endothelial adhesion, as well expression MMP-9 tissue inhibitor MMP-9, TIMP-1, were first vitro coculture systems. In addition, we used...
Ferumoxtran-10 is an MRI contrast agent, which accumulates in macrophages and induces magnetic susceptibility artifacts (MSAs). We evaluated the ability of ferumoxtran-10-enhanced to quantify focal macrophage infiltration aortic wall hypercholesterolemic rabbits.Six weeks after a double-balloon injury infrarenal aorta, 12 rabbits underwent aorta before (first MRI) (second intravenous injection ferumoxtran-10 (n=10) or saline (n=2). A third was performed 5 days later detect...
Recombinant adenoviruses are the most efficient vectors with which to perform arterial gene transfer.Previous in vivo studies of adenovirus-mediated transfection, however, have been performed using normal or endothe- lium-denuded arteries.It is unclear whether these results can be extended atherosclerotic arteries.Accordingly, this study was designed (a) assess feasibility adenovirus- mediated transfer lesions, and (b) compare transfection efficiency, anatomic distribution transfected cells,...