A5062244421- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Acute Ischemic Stroke Management
- Blood Pressure and Hypertension Studies
- Lipoproteins and Cardiovascular Health
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Imaging and Diagnostics
- Cardiovascular Disease and Adiposity
- Antiplatelet Therapy and Cardiovascular Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutritional Studies and Diet
- Heart Rate Variability and Autonomic Control
- Aortic Thrombus and Embolism
- Atherosclerosis and Cardiovascular Diseases
- Cerebral Venous Sinus Thrombosis
- Cardiac tumors and thrombi
- Moyamoya disease diagnosis and treatment
- Neurological Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Aortic Disease and Treatment Approaches
- Cancer Treatment and Pharmacology
- Acute Myocardial Infarction Research
- Blood Coagulation and Thrombosis Mechanisms
- Peripheral Artery Disease Management
Hôpital Bichat-Claude-Bernard
2008-2024
Laboratoire de Recherche Vasculaire Translationnelle
2017-2023
Assistance Publique – Hôpitaux de Paris
2004-2023
Inserm
2010-2023
Université Paris Cité
2010-2023
Chinese University of Hong Kong
2017-2020
International University of Health and Welfare
2017-2020
Sorbonne Paris Cité
2013-2020
Délégation Paris 7
2007-2020
Sanno Medical Center
2017-2020
Intima-media thickness (IMT) provides a surrogate end point of cardiovascular outcomes in clinical trials evaluating the efficacy risk factor modification. Carotid artery plaque further adds to assessment. It is defined as focal structure that encroaches into arterial lumen at least 0.5 mm or 50% surrounding IMT value demonstrates >1.5 measured from media-adventitia interface intima-lumen interface. The scientific basis for use and practice includes ultrasound physics, technical...
Intima-media thickness (IMT) is increasingly used as a surrogate end point of vascular outcomes in clinical trials aimed at determining the success interventions that lower risk factors for atherosclerosis and associated diseases (stroke, myocardial infarction peripheral artery diseases). The necessity to promote further criteria distinguish early atherosclerotic plaque formation from thickening IMT standardize measurements expressed through this updated consensus. Plaque defined focal...
Atherosclerotic disease of the aortic arch has been suspected to be a potential source cerebral emboli. We conducted study quantify risk ischemic stroke associated with atherosclerotic arch.
604 Patients with atherothrombotic cerebral ischemic events (transient, 16%: or completed, 84%) referrable either to the carotid vertebral-basilar circulation were entered into a double blind randomized clinical trial (AICLA) determine whether aspirin (A) (1 g/day) + Dipyridamole (225 mg/day) (AD) would produce significant reduction in subsequent (3 years) occurrence of fatal and nonfatal infarction. Randomization produced remarkably comparable treatment groups this good comparability was...
Previous studies conducted between 1997 and 2003 estimated that the risk of stroke or an acute coronary syndrome was 12 to 20% during first 3 months after a transient ischemic attack (TIA) minor stroke. The TIAregistry.org project designed describe contemporary profile, etiologic factors, outcomes in patients with TIA who receive care health systems now offer urgent evaluation by specialists.We recruited had within previous 7 days. Sites were selected if they dedicated TIA. We 1-year...
The use of intensive lipid-lowering therapy by means statin medications is recommended after transient ischemic attack (TIA) and stroke atherosclerotic origin. target level for low-density lipoprotein (LDL) cholesterol to reduce cardiovascular events has not been well studied.
After a transient ischemic attack (TIA) or minor stroke, the long-term risk of stroke and other vascular events is not well known. In this follow-up to report on 1-year outcomes from registry TIA clinics in 21 countries that enrolled 4789 patients with 2009 through 2011, we examined 5-year events.
The aim of this study was to assess the prevalence asymptomatic carotid atherosclerotic lesions and their relation principal risk factors. importance between lesions, stroke, coronary atherosclerosis has been widely discussed, but there are few transversal longitudinal studies on a general population.A noninvasive examination carried out using high-resolution B-mode ultrasonography, which shown be reliable tool for epidemiological studies. We examined 630 men 718 women aged 18-99 years...
Abstract This study examined the relation between arterial wall thickness and local atherosclerosis in carotid arteries (CAs) their specific risk factors. B-mode ultrasonography of CAs was performed a cohort 516 men 756 women aged 59 to 71 years who had been recruited for European Vascular Aging Study. Ultrasound examination included measurement intima-media common CA (CCA) sites plaque internal bifurcations. Significant associations increases CCA both presence severity atherosclerotic were...
Background —The use of intima-media thickness (IMT) as an outcome measure in observational studies and intervention trials relies on the view that it reflects early stages atherosclerosis cardiovascular risk. There is little knowledge concerning relation between IMT brain infarction (BI). Methods Results —We investigated with BI its subtypes 470 cases 463 controls. Cases proven by MRI were consecutively recruited classified into cause BI. Controls among individuals hospitalized at same...
The role of the increase in common carotid artery (CCA) intima-media wall thickness (IMT) atherosclerotic process is questionable. This longitudinal study examined predictive value CCA-IMT measured at baseline examination (at sites free plaques) on occurrence plaques extracranial arteries during 4 years follow-up a sample 1010 subjects aged 59 to 71 years. Ultrasound examinations were performed and 2 later. was defined as appearance >/=1 plaque previously normal segments and/or new that had...
The prevalence of carotid atherosclerosis and its risk factors was examined in 517 apparently healthy French women, aged 45-54 years. Early phases were assessed by B-mode ultrasonography. An intimal-medial thickening found 30.4% the women atheromatous plaques 8.7%. rate increased with age, smoking, postmenopausal status. However, after adjustment for effect did not have more atherosclerotic lesions than premenopausal women. No significant associations between triglyceride, apolipoprotein...
The Framingham stroke risk score (FSRS) and cardiovascular (FCRS) estimate the individual absolute risks. Common carotid artery intima-media thickness (CCA-IMT) plaques (CPs) are markers of subclinical atherosclerosis help in early identification presymptomatic individuals. purpose this study was to correlate (FRS) with CCA-IMT CPs evaluate their respective contribution risk.In 510 consecutive patients brain infarction matched controls, we calculated FSRS FCRS for each performed...
Prevention of menstrual migraine by percutaneous oestradiolRoughly 60% women with relate the periodicity their headaches to cycles, and about a quarter these have exclusively at time menstruation.1 2 The physiological withdrawal oestrogen during premenstrual phase cycle has been suggested be precipitating event leading attacks.3We investigated effect treatment percu- taneous oestradiol on attacks.
Background and Purpose— Carotid angioplasty stenting (CAS) may be more often associated with residual or recurrent stenosis than carotid endarterectomy (CEA). We compared the rates of restenosis in patients treated CAS CEA EVA-3S trial. Methods— Five hundred seven (242 by 265 CEA) had ultrasound follow-up (mean follow-up, 2.1 years) according to a predefined protocol. 50% 69% was diagnosed on planimetry, whereas ≥70% occlusion using either planimetry velocity criteria. Results— The rate ≥50%...
Methodology High-resolution B-mode imaging is a reliable, easily performed and non-invasive means of studying atherosclerosis in superficial blood vesseis. Recently it has been used for vivo studies on the thickness common carotid artery wall. It very sensitive, although results practical investigations are highly dependent both operator direction angle ultrasound beams directed towards vessel. Protocol We have assessed inter- intra-observer reproducibility measurement wall 13 subjects,...