Peter J. Kelly
A5068362864- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Atrial Fibrillation Management and Outcomes
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Atherosclerosis and Cardiovascular Diseases
- Inflammasome and immune disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Folate and B Vitamins Research
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular Health and Disease Prevention
- Peripheral Artery Disease Management
- Cardiac Arrhythmias and Treatments
- Clinical practice guidelines implementation
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Imaging and Diagnostics
- Adipokines, Inflammation, and Metabolic Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Myocardial Infarction Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebral Venous Sinus Thrombosis
- Dementia and Cognitive Impairment Research
- Healthcare Systems and Practices
Mater Misericordiae University Hospital
2016-2025
University College Dublin
2016-2025
Health Research Board
2017-2025
Cancer Trials Ireland
2024
Biomedical Research Institute
2024
Hospital de Sant Pau
2022-2024
University College London
2024
University College Cork
2024
St. Vincent's University Hospital
2014-2024
Cork University Hospital
2005-2024
After a transient ischemic attack (TIA) or minor stroke, the long-term risk of stroke and other vascular events is not well known. In this follow-up to report on 1-year outcomes from registry TIA clinics in 21 countries that enrolled 4789 patients with 2009 through 2011, we examined 5-year events.
Symptomatic carotid stenosis is associated with a 3-fold risk of early stroke recurrence compared to other subtypes. Current imaging techniques rely on estimating plaque-related lumen narrowing but do not evaluate intraplaque inflammation, key mediator plaque rupture and thromboembolism. Using combined (18) F-fluorodeoxyglucose positron-emission tomography (FDG-PET)/computed tomography, we investigated the relation between inflammation-related FDG uptake recurrence.Consecutive patients...
Improving stroke services is critical for reducing the global burden. The World Stroke Organization-World Health Organization-Lancet Neurology Commission on conducted a survey of status in low and middle-income countries (LMICs) compared to high-income countries.Using validated Organization comprehensive questionnaire, we collected data along four pillars quadrangle (surveillance, prevention, acute stroke, rehabilitation) 84 across regions economic strata. also non-communicable diseases 194...
The effect of early as compared with later initiation direct oral anticoagulants (DOACs) in persons atrial fibrillation who have had an acute ischemic stroke is unclear.We performed investigator-initiated, open-label trial at 103 sites 15 countries. Participants were randomly assigned a 1:1 ratio to anticoagulation (within 48 hours after minor or moderate on day 6 7 major stroke) (day 3 4 stroke, 12, 13, 14 stroke). Assessors unaware the trial-group assignments. primary outcome was composite...
Background: Inflammatory bowel diseases have significant long‐term morbidity and healthcare resource consequences. Studies based on secondary care records may underestimated the contribution of general practitioners (GPs) to its management. Aims: To describe epidemiology management inflammatory disease using GP as primary data source. Methods: A systematic search clinical in northern England, identifying cases disease, patient consultation behaviour, prescribing patterns, extent specialist...
Experimental stroke studies indicate that oxidative stress is a major contributing factor to ischemic cerebral injury. Oxidative also implicated in activation of matrix metalloproteinases (MMPs) and blood-brain barrier injury after ischemia-reperfusion. Plasma biomarkers may have utility as early indicators efficacy Phase 2 trials antioxidant therapies human stroke. To date, valid biomarker has been unavailable. We measured F2-isoprostanes (F2IPs), free-radical induced products neuronal...
<i>Background:</i> Prospective population-based studies are important to accurately determine the incidence and characteristics of stroke associated with atrial fibrillation (AF), while avoiding selection bias which may complicate hospital-based studies. <i>Methods:</i> We investigated AF-associated within North Dublin Population Stroke Study, a prospective cohort study stroke/transient ischaemic attack in 294,592 individuals, according recommended criteria for...
Background and Purpose— Reliable etiologic classification of ischemic stroke may enhance clinical trial design identification subtype-specific environmental genetic risk factors. Although new systems (Causative Classification System [CCS] ASCO [A for atherosclerosis, S small vessel disease, C cardiac source, O other cause]) have been developed to improve subtype assignment, few comparative data exist from large studies. We hypothesized that both CCS would reduce the proportion patients...
Matrix metalloproteinase-9 (MMP9) is expressed in acute ischemic stroke and up-regulated by tissue plasminogen activator (tPA) animal models. The authors investigated plasma MMP9 its endogenous inhibitor, inhibitor of metalloproteinase (TIMP1), tPA-treated -untreated patients.Nonstroke control subjects consecutive patients presenting within 8 hours onset were enrolled. Blood was sampled at 24 hours, 2 to 5 days 4 6 weeks. TIMP1 analyzed ELISA gel zymography.Fifty-two cases (26 tPA treated,...
Background and Purpose— The ABCD system was developed to predict early stroke risk after transient ischemic attack. Incorporation of brain imaging findings has been suggested, but reports have used inconsistent methods underpowered. We therefore performed an international, multicenter collaborative study the prognostic performance 2 score infarction on determine optimal weighting in (ABCD I). Methods— Twelve centers provided unpublished data scores, presence either diffusion-weighted or CT,...
Background and Purpose— Although symptomatic carotid stenosis is associated with 3-fold increased risk of early stroke recurrence, the pathophysiologic mechanisms high have not been established. We aimed to investigate relationship between recurrence after initial symptoms histological features plaque inflammation instability in resected plaque. Methods— Carotid endarterectomy tissue from consecutive patients ipsilateral ≥50% recent were analyzed using a validated histopathologic algorithm...
The aim of the present European Stroke Organisation Transient Ischaemic Attack (TIA) management guideline document is to provide clinically useful evidence-based recommendations on approaches triage, investigation and secondary prevention, particularly in acute phase following TIA. guidelines were prepared Standard Operational Procedure for a according GRADE methodology. As basic principle, we defined TIA pragmatically generalisability as transient neurological symptoms, likely be due focal...
Background and Purpose- Plaque inflammation contributes to stroke coronary events. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) identifies plaque inflammation-related metabolism. Almost no prospective data exist on the relationship of carotid 18F-FDG uptake early recurrent stroke. Methods- We did a multicenter cohort study BIOVASC (Biomarkers/Imaging Vulnerable Atherosclerosis in Symptomatic Carotid disease) patients with stenosis recent stroke/transient ischemic attack...