Angelika Alonso
A5089756794- Acute Ischemic Stroke Management
- Ultrasound and Hyperthermia Applications
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Photoacoustic and Ultrasonic Imaging
- Intracerebral and Subarachnoid Hemorrhage Research
- Emergency and Acute Care Studies
- Healthcare Decision-Making and Restraints
- Ultrasound and Cavitation Phenomena
- Infectious Encephalopathies and Encephalitis
- Cerebral Venous Sinus Thrombosis
- Neurosurgical Procedures and Complications
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Advanced MRI Techniques and Applications
- Psychiatric care and mental health services
- Blood Coagulation and Thrombosis Mechanisms
- Bacterial Infections and Vaccines
- Protease and Inhibitor Mechanisms
- Mesenchymal stem cell research
- Thermal Regulation in Medicine
- Cardiac Health and Mental Health
- Intensive Care Unit Cognitive Disorders
Heidelberg University
2016-2025
University Hospital Heidelberg
2016-2025
Bernstein Center for Computational Neuroscience Heidelberg-Mannheim
2020-2025
University Medical Centre Mannheim
2016-2025
Medizinische Fakultät Mannheim
2016-2024
German Cancer Research Center
2009-2022
Neurology, Inc
2016
University of Mannheim
2009-2015
University of Bern
2015
Hospital Universitario Ramón y Cajal
2012
The effect of early as compared with later initiation direct oral anticoagulants (DOACs) in persons atrial fibrillation who have had an acute ischemic stroke is unclear.We performed investigator-initiated, open-label trial at 103 sites 15 countries. Participants were randomly assigned a 1:1 ratio to anticoagulation (within 48 hours after minor or moderate on day 6 7 major stroke) (day 3 4 stroke, 12, 13, 14 stroke). Assessors unaware the trial-group assignments. primary outcome was composite...
BackgroundEndovascular treatment (EVT) of stroke with large-vessel occlusion is known to be safe and effective. The effect EVT for medium or distal vessels unclear.MethodsWe randomly assigned participants an isolated (occlusion the nondominant codominant M2 segment middle cerebral artery [MCA]; M3 M4 MCA; A1, A2, A3 anterior artery; P1, P2, P3 posterior artery) receive plus best medical alone within 24 hours after participant was last seen well. primary outcome level disability at 90 days,...
Whether infarct size modifies the treatment effect of early vs late direct oral anticoagulant (DOAC) initiation in people with ischemic stroke and atrial fibrillation is unknown.
Background and Purpose— Molecular imaging of therapeutic interventions with targeted agents that simultaneously carry drugs or genes for local delivery is appealing. We investigated the ability a novel microbubble carrier (immunobubble) abciximab, glycoprotein IIb/IIIa receptor inhibitor, ultrasonographic molecular human clots. Methods— Human thrombi were incubated immunobubbles conjugated abciximab. Control clots in either saline nonspecific antibody. evaluated immunobubble suspensions...
Delivery of drugs and macromolecules to the central nervous system (CNS) is hindered by blood-brain barrier (BBB). Several approaches have been used overcome this hindrance facilitate treatment various CNS diseases. We now present results showing that chimeric adeno-associated virus 2/1 (AAV2/1) particles containing coding region for LacZ gene are efficiently delivered into rat brain upon intravenous (IV) administration after BBB opening focused ultrasound in presence vascular acoustic...
Importance The net clinical effect of early vs later direct oral anticoagulant (DOAC) initiation after atrial fibrillation–associated ischemic stroke is unclear. Objective To investigate whether DOAC treatment associated with a benefit (NCB). Design, Setting, and Participants This was post hoc analysis the Early Versus Late Initiation Direct Oral Anticoagulants in Post–Ischaemic Stroke Patients With Atrial Fibrillation (ELAN) open-label randomized trial conducted across 103 sites 15...
Several clinical scales have been developed for predicting stroke recurrence. These scores could be extremely useful to guide triage decisions. Our goal was compare the very early predictive accuracy of most relevant [age, blood pressure, features and duration symptoms (ABCD) score, ABCD diabetes (ABCD2) brain infarction on imaging ABCD2 prior TIA within 1 week index event (ABCD3) California Risk Score, Essen Stroke Score Prognosis Instrument II] in consecutive transient ischemic attack...
The prognosis of stroke patients admitted to intensive care units (ICU) is commonly regarded be poor. However, only limited data regarding outcome predictors are available.Out 4,958 consecutive our unit with the diagnosis acute stroke, after analysis we identified 347 (164 male) in need ICU management. In-hospital and post-rehabilitation mortality as well functional at discharge rehabilitation were analyzed.Ischemic was diagnosed 252 (72.6%) intracerebral hemorrhage occurred 95 (27.4%). mean...
Acute ischemic stroke patients may occasionally suffer from concomitant acute coronary syndrome (ACS). Troponin I and T are established biomarkers to detect ACS. Recently introduced high-sensitive cardiac troponin (hs-TNI hs-TNT) assays increasingly used identify ACS in even without signs or symptoms of These new test systems very often elevated values hs-troponin, although clinical relevance consequences hs-TNI these unclear so far.We examined 834 consecutive admitted our Comprehensive...
Background and Purpose- We aimed to determine the safety mortality after mechanical thrombectomy in patients taking vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs). Methods- In a multicenter observational cohort study, we used multiple logistic regression analysis evaluate associations of symptomatic intracranial hemorrhage (sICH) with VKA DOAC prescription before as compared no anticoagulation. The primary outcomes were rate sICH all-cause at 90 days, incorporating...
Abstract Background Acute symptomatic epileptic seizures are frequently seen in neurocritical care. To prevent subsequent unprovoked seizures, long-term treatments with antiseizure medications often initiated although supporting evidence is lacking. This study aimed at prospectively assessing the risk of seizure relapse respect to use medications. It was hypothesized that after a first acute structural etiology, cumulative 12-month ≤ 25%. Methods Inclusion criteria were age ≥ 18 and...
Background Hematoma expansion after intracranial hemorrhage (ICH) in anticoagulated patients signifi-cantly influences clinical outcomes and mortality, emphasizing the need for effective reversal agents. Andexanet alfa is a specific agent factor Xa associated major bleeding. Aims The ASTRO-DE study collected real-world evidence on effect of andexanet mitigat-ing hematoma altering prognosis rivaroxaban- or apixaban-treated with ICH. Methods was prospective non-interventional cohort conducted...
Elevated cardiac troponin (cTn) levels (representing myocardial injury) are frequently found in patients with spontaneous intracerebral hemorrhage (sICH). Overall, the relationship between sICH and elevated cTn is not well understood. The aim of this study was to investigate patient characteristics clinical parameters injury. This a retrospective observational based on Mannheim Stroke database. Consecutive cases acute symptomatic available high-sensitivity I (hs-cTnI) at hospital admission...
Abstract Background Patients with epileptic seizures represent a significant proportion of emergency department (ED) admissions and are often referred for cranial imaging due to suspected or observed trauma. Neurological guidelines provide limited advice on indications in this scenario, traumatological clinical decision rules the use CT mild traumatic brain injury explicitly exclude patients preceding This gap recommendations may contribute overimaging trauma rule-out after seizure. Methods...
Ultrasound-induced opening of the blood-brain barrier (BBB) is an emerging technique for targeted drug delivery to central nervous system. Gap junctions allow transfer information between adjacent cells and are responsible tissue homeostasis. We examined effect ultrasound-induced BBB on structure gap in cortical neurons, expressing Connexin 36, astrocytes, 43, after focused 1-MHz ultrasound exposure at 1.25 MPa one hemisphere together with intravenous microbubble (Optison, Oslo, Norway)...
Crucial issues of modern stroke care include best practice end-of-life-decision (EOLD)-making procedures and the provision high-quality palliative for dying patients.We retrospectively analyzed records those patients who died over a 4-year period (2011-2014) on our Stroke Unit concerning EOLD, focusing factors that most probably guided decisions to induce limitation life-sustaining therapy subsequently end-of-life-care thereafter.Of all treated at Unit, 120 (2.71%) died. In 101 (86.3%),...
Abstract Background and objectives In 2020, a wide range of hygiene measures was implemented to mitigate infections caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). consequence, pulmonary due other pathogens also decreased. Here, we evaluated number bacterial viral meningitis encephalitis cases during disease 2019 (COVID-19) pandemic. Methods multicentre retrospective analysis data from January 2016 until December numbers patients diagnosed with types CNS (such as...