Laura Mechtouff
A5005580042- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- COVID-19 and healthcare impacts
- Atrial Fibrillation Management and Outcomes
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiovascular Health and Disease Prevention
- Healthcare Systems and Practices
- Cardiac Imaging and Diagnostics
- Long-Term Effects of COVID-19
- Antiplatelet Therapy and Cardiovascular Diseases
- Health, Medicine and Society
- Cardiovascular Function and Risk Factors
- Medical Imaging and Analysis
- Neurological Complications and Syndromes
- Blood Pressure and Hypertension Studies
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- Advanced MRI Techniques and Applications
- Parathyroid Disorders and Treatments
- Cerebrovascular and genetic disorders
- Adipokines, Inflammation, and Metabolic Diseases
Laboratoire CarMeN
2020-2025
Hospices Civils de Lyon
2016-2025
Institut National des Sciences Appliquées de Lyon
2013-2025
Inserm
2015-2025
Université Claude Bernard Lyon 1
2015-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2021-2025
Hôpital Pierre Wertheimer
2015-2024
Health and Education Research Management and Epidemiologic Services (United States)
2023
Olea Medical (France)
2023
Hôpital Louis Pradel
2013-2023
Trials of patent foramen ovale (PFO) closure to prevent recurrent stroke have been inconclusive. We investigated whether patients with cryptogenic and echocardiographic features representing risk would benefit from PFO or anticoagulation, as compared antiplatelet therapy.In a multicenter, randomized, open-label trial, we assigned, in 1:1:1 ratio, 16 60 years age who had recent attributed PFO, an associated atrial septal aneurysm large interatrial shunt, transcatheter plus long-term therapy...
Background and Purpose: The efficiency of prehospital care chain response the adequacy hospital resources are challenged amid coronavirus disease 2019 (COVID-19) outbreak, with suspected consequences for patients ischemic stroke eligible mechanical thrombectomy (MT). Methods: We conducted a prospective national-level data collection treated MT, ranging 45 days across epidemic containment measures instatement, during same calendar period in 2019. primary end point was variation receiving MT...
The COVID-19 pandemic led to profound changes in the organization of health care systems worldwide.We sought measure global impact on volumes for mechanical thrombectomy, stroke, and intracranial hemorrhage hospitalizations over a three-month period at height (1 March-31 May 2020) compared with two control periods (immediately preceding one year prior).Retrospective, observational, international study, across 6 continents, 40 countries, 187 comprehensive stroke centers. diagnoses were...
<h3>Importance</h3> The best reperfusion strategy in patients with acute minor stroke and large vessel occlusion (LVO) is unknown. Accurately predicting early neurological deterioration of presumed ischemic origin (END<sub>i</sub>) following intravenous thrombolysis (IVT) this population may help to select candidates for immediate transfer additional thrombectomy. <h3>Objective</h3> To develop validate an easily applicable predictive score END<sub>i</sub>following IVT LVO. <h3>Design,...
A reduction of ADA2 activity due to autosomal recessive loss function mutations in CECR1 results a newly described vasculopathic phenotype reminiscent polyarteritis nodosa, with manifestations ranging from fatal systemic vasculitis multiple strokes children limited cutaneous disease middle-aged individuals. Evidence indicates that is essential for the endothelial integrity small vessels. However, not expressed, nor protein detectable, cultured human cells, thus implicating additional cell...
Background During the COVID-19 pandemic, decreased volumes of stroke admissions and mechanical thrombectomy were reported. The study’s objective was to examine whether subarachnoid haemorrhage (SAH) hospitalisations ruptured aneurysm coiling interventions demonstrated similar declines. Methods We conducted a cross-sectional, retrospective, observational study across 6 continents, 37 countries 140 comprehensive centres. Patients with diagnosis SAH, aneurysmal identified by prospective...
We examined whether IV administration of cyclosporine in combination with thrombolysis might reduce cerebral infarct size.Patients aged 18 to 85 years, presenting an anterior-circulation stroke and eligible for thrombolytic therapy, were enrolled this multicenter, single-blinded, controlled trial. Fifteen minutes after randomization, patients received either bolus injection 2.0 mg/kg (Sandimmune, Novartis) or placebo. The primary endpoint was volume on MRI at 30 days. Secondary endpoints...
<b><i>Background:</i></b> We evaluated the management, outcome and haemorrhagic risk in a cohort of ischaemic stroke patients with mild symptoms treated intravenous tissue plasminogen activator (tPA) within first 4.5 h. <b><i>Methods:</i></b> analysed data from prospective thrombolysis registry. A total 1,043 received tPA between 2010 2014 5 units RESUVAL network (Rhône Valley, France). Among them, 170 had National Institute Health Stroke Scale...
Background and Purpose- The TST trial (Treat Stroke to Target) evaluated the benefit of targeting a LDL (low-density lipoprotein) cholesterol <70 mg/dL reduce risk cardiovascular events in 2860 patients with ischemic stroke atherosclerotic stenosis cerebral vasculature or aortic arch plaque >4 mm, French Korean population. follow-up lasted median 5.3 years (similar time SPARCL [Stroke Prevention by Aggressive Reduction Cholesterol Level]) 2.0 patients. Exposure duration statin is well-known...
Objective To assess the relationship between matrix metalloproteinase 9 (MMP-9), a proteolytic enzyme involved in breakdown of blood-brain barrier, and infarct growth hemorrhagic transformation ischemic stroke with large vessel occlusion (LVO) era mechanical thrombectomy (MT) using kinetics MMP-9 sequential magnetic resonance imaging (MRI). Methods HIBISCUS-STROKE is cohort study including patients admitted for an LVO treated MT following admission MRI. Patients underwent assessment MMP-9,...
In ischemic stroke, inflammatory status may condition the development of collateral circulation. Here we assessed relationship between systemic biomarkers and in large vessel occlusion before mechanical thrombectomy.HIBISCUS-STROKE is a cohort study including acute stroke patients with treated thrombectomy following admission magnetic resonance imaging. MMP-9 (matrix metalloproteinase-9) MCP-1 (monocyte chemoattractant protein-1) were measured on blood sampling collected at admission....
Background and purpose Asymptomatic intracranial hemorrhage (aICH) is a common occurrence after endovascular treatment (EVT) for acute ischemic stroke (AIS). The aims of this study were to address its impact on 3‐month functional outcome identify risk factors aICH EVT. Methods Patients with AIS attributable anterior circulation large vessel occlusion who underwent EVT enrolled in multicenter prospective registry. Based imaging performed 22–36 h post‐EVT, we included patients no (ICH) or...
The aim of this study was to investigate the relationship between baseline blood-brain barrier (BBB) permeability and kinetics circulating inflammatory markers in a cohort acute ischemic stroke (AIS) patients treated with mechanical thrombectomy.
Using a translational approach with an ST-segment myocardial infarction (STEMI) cohort and mouse model of infarction, we highlighted the role secreted IL-6 MCP-1 cytokines STAT3 pathway in heart macrophage recruitment activation. Cardiac myocytes secrete response to hypoxic stress, leading and/or polarization anti-inflammatory macrophages via pathway. In our preclinical neutralization or reduced infarct size. Together, data demonstrate that can be deleterious acute phase STEMI.
Background Studies on the role of blood pressure ( BP ) variability specifically during mechanical thrombectomy MT are sparse and limited. Moreover, pulse PP has not been considered as a potent hemodynamic parameter to describe . We assessed impact functional outcome in acute ischemic stroke patients with large vessel occlusion Methods Results Acute presenting from January 2012 June 2016 were included. data prospectively collected ETIS (Endovascular Treatment Ischemic Stroke) registry....
To assess whether interleukin-6 (IL-6) level is a marker of futile reperfusion in patients with acute ischemic stroke (AIS) large vessel occlusion treated mechanical thrombectomy (MT).The Cohort Patients to Identify Biological and Imaging Markers Cardiovascular Outcomes Stroke (HIBISCUS-STROKE) includes AIS MT after MRI. We performed sequential assessment IL-6 (admission, 6 hours, 24 48 hours 3 months from admission). Among successful (Thrombolysis Cerebral Infarction scale 2b/3), was...