Seby John

ORCID: 0000-0003-0894-0657
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Research Areas
  • Acute Ischemic Stroke Management
  • Cerebrovascular and Carotid Artery Diseases
  • Intracranial Aneurysms: Treatment and Complications
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Neurological Complications and Syndromes
  • Stroke Rehabilitation and Recovery
  • Long-Term Effects of COVID-19
  • COVID-19 and healthcare impacts
  • Moyamoya disease diagnosis and treatment
  • Vascular Malformations Diagnosis and Treatment
  • Neurosurgical Procedures and Complications
  • Vasculitis and related conditions
  • Cerebral Venous Sinus Thrombosis
  • Venous Thromboembolism Diagnosis and Management
  • Neurological and metabolic disorders
  • Aortic Disease and Treatment Approaches
  • Retinal and Optic Conditions
  • Glioma Diagnosis and Treatment
  • Brain Metastases and Treatment
  • Ocular Diseases and Behçet’s Syndrome
  • Sarcoidosis and Beryllium Toxicity Research
  • Systemic Lupus Erythematosus Research
  • Renal and Vascular Pathologies
  • Peripheral Nerve Disorders
  • Anesthesia and Neurotoxicity Research

Cleveland Clinic
2014-2025

Abu Dhabi Health Services
2019-2025

Cleveland Eye Clinic
2021-2025

Case Western Reserve University
2024

Cleveland Clinic Lerner College of Medicine
2024

The Neurological Institute
2013-2024

Icahn School of Medicine at Mount Sinai
2024

Health and Education Research Management and Epidemiologic Services (United States)
2023

Bacha Khan University
2023

Boston Medical Center
2021-2022

Background— Atrial fibrillation (AF) ablation is increasingly used in clinical practice. We aimed to study the natural history and long-term outcomes of ablated AF. Methods Results— followed 831 patients after pulmonary vein isolation (PVI) performed 2005. documented using our prospective AF registry with most recent update on this group October 2009. In first year ablation, 23.8% had early recurrence. Over follow-up (55 months), only 8.9% late arrhythmia recurrence defined as occurring...

10.1161/circep.111.962100 article EN Circulation Arrhythmia and Electrophysiology 2011-04-15

There is scant information on in-stent stenosis after flow diversion treatment of intracranial aneurysms with the Pipeline Embolization Device (PED).To assess incidence, severity, nature, and clinical consequences angiographic follow-up PED.A retrospective study patients who underwent aneurysm PED was conducted. In-stent assessed subsequent angiography. Intimal hyperplasia defined as a uniform growth process beyond limits metallic mesh at <25%. represented an area parent vessel narrowing,...

10.1227/neu.0000000000001146 article EN Neurosurgery 2015-11-24

Favorable outcomes in intraarterial therapy (IAT) for acute ischemic stroke (AIS) are related to early vessel recanalization. The mobile treatment unit (MSTU) is an on-site, prehospital, team, laboratory, and CT scanner that reduces time intravenous thrombolysis may also shorten IAT.Using our MSTU database, we identified patients underwent IAT AIS. We compared the key metrics historical controls, which included at institution six months prior implementation of MSTU. further divided controls...

10.1111/jon.12276 article EN Journal of Neuroimaging 2015-07-14

Long-term outcomes of reversible cerebral vasoconstriction syndrome (RCVS) have not been systematically investigated.The following validated questionnaires were mailed to patients recruited from the RCVS registries two academic hospitals: headache screening form, Headache Impact Test, Migraine Disability Assessment Barthel Index (BI), EuroQoL (EQ-5D-5L) and Patient Health Questionnaire (PHQ-9).Of 191 in registries, 109 could be contacted 45 responded. Median follow-up time after symptom...

10.1177/0333102415591507 article EN Cephalalgia 2015-06-18

<h3>SUMMARY:</h3> The mechanisms and phenotype of ischemic stroke associated with coronavirus disease 2019 (COVID-19) remain uncertain. A retrospective study was conducted in patients COVID-19 presenting from March 1 to May 25, 2020, cases large-vessel occlusion were identified. To provide baseline institutional data within outside the pandemic, all consecutive TIA admissions (COVID non-COVID) hospital during a 10-week period 10, collected compared same time 2019. Among 20 acute stroke, 15...

10.3174/ajnr.a6799 article EN cc-by American Journal of Neuroradiology 2020-08-27
Osama O. Zaidat Ricardó A. Hanel Eric Sauvageau Amin Aghaebrahim Eugene Lin and 95 more Ashutosh P. Jadhav Tudor Jovin Ahmad Khaldi Rishi Gupta Andrew K. Johnson Donald Frei David Loy Adel M. Malek Gábor Tóth Adnan H. Siddiqui John Reavey‐Cantwell Ajith J. Thomas Steven W. Hetts Brian T. Jankowitz Bradley A. Gross Andrew F. Ducruet David Panczkowski Hazem Shoirah Alhamza R Al‐Bayati Greg Weiner Cynthia L. Kenmuir Prasanna Tadi Gregory Walker Kendrick Johnson Don Frei Richard Bellon Benjamin Atchie Ian Kaminsky Dan Huddle Mark Bain Peter A. Rasmussen M. Shazam Hussain Nina Z. Moore T. Masaryk Mohamed Elgabaly Russell Cerejo Julian Hardman Seby John Andrew M. Bauer Jenny Tsai Elad I. Levy Kenneth V. Snyder Jason M. Davies Christopher S. Ogilvy Dennis J. Rivet Michael J. Alexander Franklin G. Moser M. Marcel Maya Michael Schiraldi Paula Eboli Justin M. Caplan Bowen Jiang Matthew T. Bender Geoffrey P. Colby Sudhakar R Satti Thinesh Sivapatham David Kung Bryan Pukenas Robert W. Hurst Michelle J. Smith Ajit S Puri Francesco Massari D Rex Justin F. Fraser Stephen Grupke Abdulnasser Alhajeri Richard Klucznik Orlando Díaz Gavin W. Britz Yi Zhan Alejandro M Spiotta Jonathan Lena Aquilla S Turk M Imran Chaudry Kyle M Fargen Raymond D Turner Peter Kan Edward Duckworth Muhammad Taqi Samuel Y Hou Adam S Arthur Lucas Elijovich Daniel Hoit Christopher Nickele Jay A. Vachhani Vinodh T Doss R. Webster Crowley Demetrius K. Lopes Michael Chen Danial K. Hallam Basavaraj Ghodke Louis J. Kim R. Charles Callison Amer Alshekhlee Sushant P. Kale

Stent-assisted coil embolization using the new generation Neuroform Atlas Stent System has shown promising safety and efficacy. The primary study results of anterior circulation aneurysm cohort treatment wide-neck, saccular, intracranial, aneurysms with (ATLAS trial [Safety Effectiveness Treatment Wide Neck, Saccular Intracranial Aneurysms With System]) are presented.ATLAS IDE (Investigational Device Exemption) is a prospective, multicenter, single-arm, open-label wide-neck (neck ≥4 mm or...

10.1161/strokeaha.119.028418 article EN cc-by Stroke 2020-06-17
Thanh N. Nguyen Diogo C Haussen Muhammad M. Qureshi Hiroshi Yamagami Toshiyuki Fujinaka and 95 more Malek Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer Eker Laura Mechtouff Michel Piotin Fabrício Oliveira Lima F. Mont’alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al‐Bayati Leonardo Renieri Salvatore Mangiafico David Ozretić Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Hussain Seby John Emma Griffin John Thornton José Antônio Fiorot Júnior Rodrigo Rivera Nadia Hammami Anna M. Cervantes‐Arslanian Hormuzdiyar H. Dasenbrock Huynh Le Vu Viet Q. Nguyen Steven W. Hetts Romain Bourcier R. Guilé Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al‐Mufti Atilla Özcan Özdemi̇r Özlem Aykaç Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale Lavoie Randall C. Edgell André Beer‐Furlan Michael Chen Monika Killer‐Oberpfalzer Vítor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega‐Gutiérrez Mudassir Farooqui Amal Abou‐Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena Adela Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A. Sheth Victor S Lopez Rivera James E. Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kühn Gianmarco Bernava Paolo Machi Daniel Giansante Abud Octávio Marques Pontes‐Neto Ajay K. Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh

Background During the COVID-19 pandemic, decreased volumes of stroke admissions and mechanical thrombectomy were reported. The study’s objective was to examine whether subarachnoid haemorrhage (SAH) hospitalisations ruptured aneurysm coiling interventions demonstrated similar declines. Methods We conducted a cross-sectional, retrospective, observational study across 6 continents, 37 countries 140 comprehensive centres. Patients with diagnosis SAH, aneurysmal identified by prospective...

10.1136/svn-2020-000695 article EN cc-by-nc Stroke and Vascular Neurology 2021-03-26

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; Recent studies have shown that intra-arterial recanalization therapy (IAT) for acute ischemic stroke (AIS) is associated with worse clinical outcomes when performed under general anesthesia (GA) compared to local anesthesia, or without conscious sedation. The reasons this association not been systematically studied. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; We retrospectively reviewed 190 patients who underwent IAT anterior circulation...

10.1159/000368216 article EN Cerebrovascular Diseases 2014-01-01

Venous sinus stenting for dural stenoses is an emerging alternative to cerebrospinal fluid diversion in cases of medically refractory idiopathic intracranial hypertension. Juxta-stent 're-stenoses' have been reported and managed alternatively with ventricular shunting or stent revision. Identification factors that might predispose patients recurrent narrowing may help select exclude hypertension venous stenting.We retrospectively reviewed a prospectively maintained database spanning December...

10.1136/neurintsurg-2016-012803 article EN Journal of NeuroInterventional Surgery 2016-12-13

There is a strong inverse relationship between outcome in patients with acute ischemic stroke from emergent large vessel occlusion (ELVO), and time to reperfusion intra-arterial therapy. Delay transferring thrombectomy-capable centers currently major limitation. The mobile unit (MSU) concept onboard portable computed tomography (CT) scanner enables rapid performance of CT angiography (CTA) the intracranial vessels detect ELVO field, allows for triage interventional-capable centers.Our...

10.1111/jon.12346 article EN Journal of Neuroimaging 2016-03-30

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; It is unknown if intraprocedural blood pressure (BP) influences clinical outcomes and what BP parameter best predicts in acute ischemic stroke (AIS) patients who undergo intra-arterial therapy (IAT) for emergent large vessel occlusion. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; We retrospectively reviewed 147 underwent IAT anterior circulation AIS from January 2008 to December 2012 at our institution. Baseline demographics, treatment...

10.1159/000444098 article EN Interventional Neurology 2015-01-01

Background There is sparse literature on the natural history of blood pressure (BP) after intra-arterial therapy (IAT) for acute ischemic stroke (AIS). Methods A retrospective analysis was performed patients with AIS who underwent IAT without endotracheal intubation internal carotid artery terminus (ICA-T) or M1 middle cerebral occlusion from January 2008 to February 2012. Systolic BP (SBP) values at beginning (First) and end (End) 36 h procedure were collected. Successful recanalization...

10.1136/neurintsurg-2016-012369 article EN Journal of NeuroInterventional Surgery 2016-04-15

10.1136/bcr-2025-265663 article EN BMJ Case Reports 2025-04-01

Five persons consumed home-salted fish and then presented with gastrointestinal symptoms to 3 hospitals; 2 of the patients had minimal cranial nerve palsies. Early serum samples obtained from all were negative for botulinum toxin. Remnant tested positive toxin type E. In exposed low doses E, may predominate.

10.1086/518993 article EN Clinical Infectious Diseases 2007-06-19

BACKGROUND.: Pancreas transplantation (PT) provides the best glycemic control option for diabetes mellitus but is associated with significant morbidities related to infectious disease. METHODS.: We performed a retrospective study of cohort consecutive PT recipients in whom was from 1998 2006 (n=216) and followed up them until July 2008. Data regarding infections, rejection, infection chemoprophylaxis, graft failure, absolute lymphocyte counts (ALCs), mortalities were collected. RESULTS.:...

10.1097/tp.0b013e3181d54bb9 article EN Transplantation 2010-03-18

To report fulminant cases of reversible cerebral vasoconstriction syndrome (RCVS) in the setting serotonin syndrome.RCVS is characterized by acute onset severe headaches, with or without neurologic deficit, evidence vasoconstriction. It often benign, and prognosis generally considered favorable. In largest prospective study on RCVS, only 4% patients were disabled from strokes there no fatalities.We a case series.We 2 women history depression selective re-uptake inhibitors who presented...

10.1111/head.12202 article EN Headache The Journal of Head and Face Pain 2013-09-03

The 5MAX ACE is a new large bore aspiration catheter available for vessel recanalization treatment of acute ischemic stroke (AIS). We report our initial experience with its use.A retrospective analysis patients undergoing intra-arterial therapy AIS using the reperfusion at institution was performed. Patient demographics, clinical characteristics and procedural data were obtained from chart review. Successful recanlization defined as achievement Thrombolysis in Cerebral Infarction score...

10.7461/jcen.2014.16.4.350 article EN cc-by-nc Journal of Cerebrovascular and Endovascular Neurosurgery 2014-01-01

Background Systemic vascular alterations have not been described in reversible cerebral vasoconstriction syndrome (RCVS). We present a case series of RCVS patients having cardiac dysfunction during ictus, with subset showing complete resolution cardiomyopathy. Methods Retrospective case-series: Cardiac left ventricular ejection fraction (LVEF) and wall motion abnormalities (WMA) visualized on transthoracic echocardiography (TTE), performed ictus follow-up was analyzed. Results Of 68...

10.1177/0333102414547139 article EN Cephalalgia 2014-08-27
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