A5076218745- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Effects of Exercise
- Cardiac tumors and thrombi
- Cardiomyopathy and Myosin Studies
- Cardiac Valve Diseases and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Disease and Adiposity
- Parathyroid Disorders and Treatments
- Mechanical Circulatory Support Devices
- Heart Rate Variability and Autonomic Control
- Cardiac Health and Mental Health
- Cardiovascular and Diving-Related Complications
- Cardiovascular Syncope and Autonomic Disorders
- Chemotherapy-induced cardiotoxicity and mitigation
- Acute Ischemic Stroke Management
- Pericarditis and Cardiac Tamponade
Cleveland Clinic
2016-2025
Cleveland Foundation
2024
Queen's University Belfast
2021
University of Pittsburgh Medical Center
2019
Diabetes Canada
2019
Mount Sinai Hospital
2019
Stanford University
2007-2019
St David's Medical Center
2011-2016
Texas Cardiac Arrhythmia
2016
American University of Beirut
2013
Patients with chronic renal failure develop a “uremic” cardiomyopathy characterized by diastolic dysfunction, cardiac hypertrophy, and systemic oxidant stress. are also known to have increases in the circulating concentrations of cardiotonic steroid marinobufagenin (MBG). On this background, we hypothesized that elevations MBG may be involved cardiomyopathy. First, observed administration (10 μg/kg per day) for 4 weeks caused comparable plasma as partial nephrectomy at weeks. infusion...
Background— The best approach to management of anticoagulation before and after atrial fibrillation ablation is not known. Methods Results— We compared outcomes in consecutive patients undergoing pulmonary vein antrum isolation for persistent fibrillation. Early our practice, warfarin was stopped 3 days ablation, a transesophageal echocardiogram performed rule out clot. Enoxaparin, initially 1 mg/kg twice daily (group 1) then 0.5 2), used “bridge” ablation. Subsequently, continued maintain...
PV isolation at the antrum (PVAI) has improved safety and efficacy of ablation procedures for atrial fibrillation (AF). AF triggers from superior vena cava (SVC) may compromise outcome PVAI. Purpose: We evaluated (1) incidence SVC triggers, (2) feasibility empiric electrical (SVCI) as an adjunct to PVAI, (3) SVCI safety. Methods Results: Of 190 patients (group I), 24 (12%) showed triggers. Following seven had AT originating three AF. After SVCI, all were arrhythmia‐free 450 ± 180 days post...
Background— Pulmonary vein isolation (PVI) for atrial fibrillation is associated with a transient increased risk of thromboembolic and hemorrhagic events. We hypothesized that dabigatran can be safely used as an alternative to continuous warfarin the periprocedural anticoagulation in PVI. Methods Results— A total 999 consecutive patients undergoing PVI were included; 376 on (150 mg), 623 therapeutic international normalized ratio. Dabigatran was held 1 2 doses before restarted at conclusion...
Background— Atrial fibrillation (AF) ablation is increasingly used in clinical practice. We aimed to study the natural history and long-term outcomes of ablated AF. Methods Results— followed 831 patients after pulmonary vein isolation (PVI) performed 2005. documented using our prospective AF registry with most recent update on this group October 2009. In first year ablation, 23.8% had early recurrence. Over follow-up (55 months), only 8.9% late arrhythmia recurrence defined as occurring...
The aim of our study was to investigate outcomes patients with ATTR (amyloidosis and transthyretin) CA (cardiac amyloidosis) implantable devices respect left ventricular ejection fraction (LVEF), mitral regurgitation (MR), New York Heart Association (NYHA) functional class, mortality.This a retrospective observational cohort 78 devices. During mean follow-up 42 months we investigated the impact right (RV) pacing burden biventricular (BiV) on LVEF, MR severity, NYHA mortality.Worsening...
Effects of contact force (CF) on lesion formation during pulsed field ablation (PFA) have not been well validated. The purpose this study was to determine the relationship between average CF and size PFA using a swine-beating heart model.
Comparative efficacy and safety data on radiofrequency ablation (RFA) versus pulsed field (PFA) for common idiopathic left ventricular arrhythmia (LV-VAs) locations are lacking. This study sough to compare RFA with PFA of LV-VAs locations. Ten swine were randomized or LV interventricular septum, papillary muscle, summit via distal coronary sinus, epicardium subxiphoid approach. Ablations delivered using an investigational dual-energy (RFA/PFA) contact force (CF) local impedance-sensing...
Perforation of a coronary venous branch for pericardial insufflation carbon dioxide (CO2) enhances safety epicardial access. The multiple procedural steps and length the procedure remain major limitation this approach impacting its routine clinical adoption. This study describes novel streamlined technique CO2 via radiofrequency (RF)-assisted right atrial appendage (RAA) perforation. Between 2023 2024, 18 patients (age: 55 ± 11 years; left ventricular ejection fraction: 44 13%) underwent...
We sought to test how catheter ablation using an open irrigation (OIC) compares with standard catheters for pulmonary vein antrum isolation. Open have the advantage of delivering greater power without increasing temperature tip, which enables deeper and wider lesions formation coagulum on catheters. Catheter was performed 8-mm (8MC) or OIC. Patients were randomized 3 groups: 8MC; OIC-1, OIC a higher peak (50 W); OIC-2, lower (35 W). A total 180 patients treatment strategies. Isolation antra...
Plasma B-type natriuretic peptide (BNP) is abnormally elevated in patients with lone atrial fibrillation (AF). The exact significance and prognostic implications of this elevation have yet to be determined. Little known about BNP AF undergoing arrhythmia ablation. We sought determine the relationship between levels risk recurrent after ablation AF.We followed up 726 first-time All had measured on day point-of-care Triage Meter assay (Biosite Diagnostics, San Diego, CA). At baseline, factors...
Background— Various ablation strategies of persistent atrial fibrillation (PersAF) have had disappointing outcomes, despite concerted clinical and research efforts, which could reflect progressive fibrillation–related remodeling. Methods Results— Two-year outcomes were assessed in 1241 consecutive patients undergoing first-time PersAF (2005–2012). The time intervals between the first diagnosis procedures determined. Patients echocardiograms measures B-type natriuretic peptide C-reactive...
Abstract Aims Atrial fibrillation (AF) occurs in as many 70% of patients with transthyretin cardiac amyloidosis (ATTR CA). The aim our study was to investigate the impact AF ablation on freedom from recurrent arrhythmia, hospitalization for or heart failure (HF), and mortality. Methods results This a retrospective observational cohort 72 ATTR CA AF, whom 24 underwent were matched 2:1 manner based age, gender, stage, New York Heart Association functional class, ejection fraction, date...