A5089382611- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Ferroelectric and Piezoelectric Materials
- Ruminant Nutrition and Digestive Physiology
- Lysosomal Storage Disorders Research
- Physics of Superconductivity and Magnetism
- Magnetic properties of thin films
- Cardiovascular Function and Risk Factors
- Virus-based gene therapy research
- Quantum and electron transport phenomena
- Multiferroics and related materials
- ECG Monitoring and Analysis
- Particle physics theoretical and experimental studies
- Mechanical Circulatory Support Devices
- Trypanosoma species research and implications
- Conducting polymers and applications
- Hydrogen Storage and Materials
- Congenital Diaphragmatic Hernia Studies
- Effects of Environmental Stressors on Livestock
- Cardiac Fibrosis and Remodeling
- Acoustic Wave Resonator Technologies
- Semiconductor materials and devices
Cleveland Clinic
2020-2025
Kagoshima University
2008-2025
Institute of Livestock and Grassland Science
2007-2024
National Agriculture and Food Research Organization
2022-2024
Hiratsuka Kyosai Hospital
2014-2023
University of California, San Francisco
2022
Cleveland Clinic Lerner College of Medicine
2021
University College London
2019
Thrombosis Research Institute
2019
Osaka University
1995-2018
Recent studies have shown that histones, the chief protein component of chromatin, are released into extracellular space during sepsis, trauma, and ischemia-reperfusion injury, act as major mediators death an organism. This study was designed to elucidate cellular molecular basis histone-induced lethality assess protective effects recombinant thrombomodulin (rTM). rTM has been approved for treatment disseminated intravascular coagulation (DIC) in Japan, is currently undergoing a phase III...
The effects of the anti-methanogenic compound, bromochloromethane (BCM), on rumen microbial fermentation and ecology were examined in vivo . Japanese goats fed a diet 50 % Timothy grass concentrate then sequentially adapted to low, mid high doses BCM. placed into respiration chambers for analysis function methane H 2 production. levels production reduced by 5, 71 91 %, was estimated at 545, 2941 3496 mmol/head per d, response BCM, respectively, with no effect maintenance feed intake...
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Background: Pulsed-field ablation (PFA) is a nonthermal energy with higher selectivity to myocardial tissue in comparison radiofrequency (RFA). We compared the effects of PFA and RFA on heterogeneous ventricular scar swine model healed infarction. Methods: In 9 swine, infarction was created by balloon occlusion left anterior descending artery. After survival period 8 10 weeks, or performed at infarct border zones identified abnormal electrograms. group (4 swine), lattice catheter (Sphere-9,...
Perforation of a coronary venous branch for pericardial insufflation carbon dioxide (CO2) enhances safety epicardial access. The multiple procedural steps and length the procedure remain major limitation this approach impacting its routine clinical adoption. This study describes novel streamlined technique CO2 via radiofrequency (RF)-assisted right atrial appendage (RAA) perforation. Between 2023 2024, 18 patients (age: 55 ± 11 years; left ventricular ejection fraction: 44 13%) underwent...
Inappropriate cardiac remodeling and repair after myocardial infarction (MI) predisposes to heart failure. Studies have reported on the potential for lineage negative, steel factor positive ( c - kit + ) bone marrow-derived hematopoetic stem∕progenitor cells (HSPCs) damaged myocardium through neovascularization myogenesis. However, precise contribution of c-kit signaling pathway process has yet be determined. In this study, we sought directly elucidate mechanistic contributions in...
Background: The prevalence, gender- and age-related differences, ablation success rate inter-relationship between the origins of idiopathic ventricular arrhythmias (I-VA) have not been clarified. Methods Results: A total 625 consecutive patients with symptomatic, drug resistant I-VA (315 males 310 females; mean age, 54±17 years; 218 tachycardias, 407 premature contractions) who underwent catheter were studied. divided into 5 groups based on VA origin: (1) outflow tract (OT)-VA, consisting...
We present results of a search for proton decays, p→¯νK+, using data from 33kt˙yr exposure the Super-Kamiokande detector. Two decay modes kaon, K+→μ+νμ and K+→π+π0, were studied. The consistent with background expected atmospheric neutrinos; therefore lower limit on partial lifetime τ/B(p→¯νK+) was found to be 6.7×1032years at 90% confidence level.Received 22 February 1999DOI:https://doi.org/10.1103/PhysRevLett.83.1529©1999 American Physical Society
Structural remodeling in chronic atrial fibrillation (AF) occurs over weeks to months. To study the electrophysiological, structural, and functional changes that occur AF, selection of best animal model is critical. AF was induced by rapid pacing (50-Hz stimulation every other second) pigs (n = 4), dogs 8), goats 9). Animals underwent MRIs at baseline 6 mo evaluate left ventricular (LV) ejection fraction (EF). Dogs were given metoprolol (50-100 mg po bid) digoxin (0.0625-0.125 limit response...
The east-west anisotropy, caused by the deflection of primary cosmic rays in Earth's magnetic field, is observed for first time flux atmospheric neutrinos. Using a 45 kt yr exposure Super-Kamiokande detector, 552 $e$-like and 633 $\ensuremath{\mu}$-like horizontally going events are selected momentum range between 400 $3000\mathrm{MeV}/c$. azimuthal distributions agree with expectation from neutrino calculations, verifying that neutrinos GeV energy reasonably well modeled calculations...
Atrial fibrillation (AF) is the most commonly encountered cardiac arrhythmia in clinical practice, with a prevalence of 0.4–1% US population.w1 AF potent risk factor, increasing stroke fivefold and accounting for approximately 15% all strokes USA.w2 also significantly increases mortality from heart failure.w3–7 Many therapies, including pharmacological approaches direct current cardioversion, have been tried to treat this malignant arrhythmia, but were not found be that effective.1...
Background— Although coronary cusp (CC) ventricular arrhythmia (VA) can be treated by catheter ablation, reliable indicators of successful ablation sites have not been fully identified. Methods and Results— This study comprised 392 patients undergoing radiofrequency for outflow tract-VA at 3 institutions from January 2007 to August 2012. The site was on the left CC or right in 35 (8.9%) patients. In 9 (26%) these patients, a discrete prepotential recognized, 5 whom had CC-VAs 4 CC-VAs....
Catheter ablation significantly improves the left ventricular (LV) function in patients with atrial fibrillation (AF) and LV systolic dysfunction. In this study, we compared degree of structural remodeling (LA-SRM) normal versus reduced ejection fraction (LVEF). We also studied impact LA-SRM on LVEF improvement undergoing AF.We categorized 384 into 2 groups based their cardiac function: group (LVEF ≤50%; n = 105) > 50%; 279). was determined prior mean 8 ± 3 months after catheter for AF....
Therapeutic effectiveness of ablation atrial fibrillation (AF) is related to cardiovascular comorbidities. We studied the relationship between left ventricular hypertrophy (LVH) and tissue structural remodelling (LA-SRM), in patients presenting for AF ablation.We identified 404 who received a late gadolinium enhancement magnetic resonance imaging (LGE-MRI) prior catheter ablation. Left was defined as LV mass index >116 g/m(2) men >104 women. One hundred twenty-two were classified LVH group...