A5005973866- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- ECG Monitoring and Analysis
- Microbial Inactivation Methods
- Cardiovascular Effects of Exercise
- Electrostatic Discharge in Electronics
- Angiogenesis and VEGF in Cancer
- Plasma Applications and Diagnostics
- Coronary Interventions and Diagnostics
- Ultrasound and Hyperthermia Applications
- Lymphatic System and Diseases
- Advanced Machining and Optimization Techniques
- Toxin Mechanisms and Immunotoxins
- Electrolyte and hormonal disorders
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Electrical and Bioimpedance Tomography
- Cardiac Imaging and Diagnostics
- Cardiac and Coronary Surgery Techniques
- Genetics, Aging, and Longevity in Model Organisms
- Telomeres, Telomerase, and Senescence
- Dialysis and Renal Disease Management
- Insect and Pesticide Research
- Electrohydrodynamics and Fluid Dynamics
Rush University Medical Center
2024-2025
Cleveland Clinic
2020-2024
Cleveland Clinic Lerner College of Medicine
2021-2022
Shaker Heights Public Library
2022
Rabin Medical Center
2015-2021
Tel Aviv University
2015-2021
Beth Israel Deaconess Medical Center
2019-2020
Harvard University
2019-2020
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Pulsed field ablation (PFA) is a nonthermal energy with potential safety advantages over radiofrequency ablation. This study investigated novel PFA system-a circular multielectrode catheter (PFA lasso) and multichannel generator designed to work Carto 3 mapping system.A 7.5F bidirectional 10 electrodes variable expansion was for (biphasic, 1800 Volts). included total of 16 swine used investigate the following experimental aims: Aim 1 examined feasibility create right atrial line block from...
Background: Pulsed-field ablation (PFA) is a nonthermal energy with higher selectivity to myocardial tissue in comparison radiofrequency (RFA). We compared the effects of PFA and RFA on heterogeneous ventricular scar swine model healed infarction. Methods: In 9 swine, infarction was created by balloon occlusion left anterior descending artery. After survival period 8 10 weeks, or performed at infarct border zones identified abnormal electrograms. group (4 swine), lattice catheter (Sphere-9,...
Background: Pulsed field ablation (PFA) is a nonthermal energy that may provide safety advantages over radiofrequency (RFA). One-shot PFA catheters have been developed for pulmonary vein isolation, but they do not permit flexible lesion sets. This study investigated novel lattice-tip catheter designed focal RFA or ablation. Methods: The effects of (biphasic, 24 amperes) were in 25 swine using and system (Affera Inc). Step 1 (n=14) examined the feasibility to create atrial line block...
Multielectrode mapping catheters can be advantageous for identifying surviving myocardial bundles in scar. This study aimed to evaluate the utility of a new multielectrode catheter with increased number small and closely spaced electrodes ventricles healed infarction.In 12 swine (four healthy eight infarction), left ventricle was mapped investigational (OctarayTM) standard (PentarayTM) catheters. The has more (48 vs. 20), each smaller surface area (0.9 2.0 mm2) spacing is fixed at 2 mm (vs....
BRCA1 mutation is associated with carcinogenesis, especially of breast tissue. Telomere maintenance crucial for malignant transformation. Being a part the DNA repair machinery, may be implicated in telomere biology. We explored role lymphocytes BRCA1/2 carriers and vitro system by knocking down its expression non-malignant epithelial cells.The results both systems were similar. caused perturbation homeostasis, shortening single stranded overhang increased intercellular length variability as...
Endocardial bipolar voltage amplitude is largely derived from endocardial and subendocardial wall layers. This may result in situations of low despite the presence mid-myocardial including epicardial (ie, intramural-epicardial) viable myocardium. study examined utility unipolar mapping for detection intramural-epicardial atrial myocardium.In 15 swine, an intercaval ablation line with intentional gap was created. Animals survived 6 to 8 weeks before electroanatomical followed by sacrifice....
Abstract Introduction Use of sodium glucose cotransporter 2 inhibitors (SGLT2i) was associated with a reduction in atrial fibrillation hospitalizations. Therefore, we aim to evaluate the effects SGLT2i on tachy‐arrhythmias (ATA) patients cardiac implantable electronic devices (CIEDs). Methods All 13 888 consecutive implanted CIED two tertiary medical centers were enrolled. Treatment assessed as time dependent variable. The primary endpoint total number ATA. Secondary endpoints included...
Background: Ventricular tachycardia ablation is often limited by insufficient lesion creation. A novel radiofrequency catheter with an expandable lattice electrode has a larger surface area capable of delivering higher currents at lower density to potentially increase dimensions without overheating. Methods: This 8F bidirectional irrigated (Sphere-9, Affera Inc) 9 mm spherical tip (“lattice”) effective 10-fold than standard linear catheters. Nine thermocouples provide temperature feedback...