Johann Pelz
A5063795980- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Heparin-Induced Thrombocytopenia and Thrombosis
- Stroke Rehabilitation and Recovery
- Vagus Nerve Stimulation Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Cerebral Venous Sinus Thrombosis
- Cardiovascular Health and Disease Prevention
- Heart Rate Variability and Autonomic Control
- Atrial Fibrillation Management and Outcomes
- Parkinson's Disease Mechanisms and Treatments
- Epilepsy research and treatment
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neurological and metabolic disorders
- Blood Coagulation and Thrombosis Mechanisms
- Amyotrophic Lateral Sclerosis Research
- Gastroesophageal reflux and treatments
- Advanced MRI Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Orthopedic Surgery and Rehabilitation
- Genetic Neurodegenerative Diseases
- Innovations in Medical Education
- Infectious Encephalopathies and Encephalitis
Leipzig University
2015-2025
University Hospital Leipzig
2015-2024
Klinik und Poliklinik für Psychotherapie und Psychosomatik
2023-2024
Population Health Research Institute
2024
McMaster University
2024
University Hospital of Bern
2023
University of Bern
2023
Klinikum Coburg
2023
Klinik und Poliklinik für Neurologie
2014-2021
Charité - Universitätsmedizin Berlin
2009
Spinal cord injury (SCI) including permanent paraplegia constitutes a common complication after repair of thoracoabdominal aortic aneurysms. The staged-repair concept promises to provide protection by inducing arteriogenesis so that the collateral network can robust blood supply spinal intervention. Minimally invasive staged segmental artery coil embolisation (MIS2ACE) has been proved recently be feasible enhanced approach repair.This randomised controlled trial uses multicentre,...
Reported sonographic reference values for the vagus nerves (VNs) vary greatly. We aimed to generate in a large cohort and examine intrarater, interrater, across-ultrasound systems agreement.The VNs of 60 healthy subjects were examined by 2 sonographers with ultrasound systems. Cross-sectional areas (CSAs) each VN assessed at level carotid sinus [proximal measurement (ML)] thyroid gland (distal ML).Mean CSA was significantly larger on right side (proximal ML: 2.7 ± 0.6 mm2 vs. 2.1 0.5 ;...
Abstract Background Acute symptomatic epileptic seizures are frequently seen in neurocritical care. To prevent subsequent unprovoked seizures, long-term treatments with antiseizure medications often initiated although supporting evidence is lacking. This study aimed at prospectively assessing the risk of seizure relapse respect to use medications. It was hypothesized that after a first acute structural etiology, cumulative 12-month ≤ 25%. Methods Inclusion criteria were age ≥ 18 and...
Background: Recent histopathological studies revealed degeneration of the dorsal motor nucleus early in course Parkinson's disease (PD). Degeneration vagus nerve (VN) axons following neurodegeneration brainstem vagal nuclei should be detectable by high-resolution ultrasound (HRUS) as a thinning VNs. Methods: We measured both VNs cross-sectional area (VN-CSA) 35 patients with PD and age- sex-matched healthy controls at level thyroid gland using HRUS. Results: On sides, VN-CSA was...
Objective Cerebral venous thrombosis (CVT) caused by vaccine‐induced immune thrombotic thrombocytopenia (VITT) is a rare adverse effect of adenovirus‐based severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) vaccines. In March 2021, after autoimmune pathogenesis VITT was discovered, treatment recommendations were developed. These comprised immunomodulation, non‐heparin anticoagulants, and avoidance platelet transfusion. The aim this study to evaluate adherence these its association...
Atrial fibrillation (AF) is one of the most frequent causes stroke. Several randomized trials have shown that prolonged monitoring increases detection AF, but effect on reducing recurrent cardioembolism, ie, ischemic stroke and systemic embolism, remains unknown. We aim to evaluate whether a risk-adapted, intensified heart rhythm with consequent guideline conform treatment, which implies initiation oral anticoagulation (OAC), leads reduction cardioembolism.Find-AF 2 randomized, controlled,...
Abstract Background and objectives In 2020, a wide range of hygiene measures was implemented to mitigate infections caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). consequence, pulmonary due other pathogens also decreased. Here, we evaluated number bacterial viral meningitis encephalitis cases during disease 2019 (COVID-19) pandemic. Methods multicentre retrospective analysis data from January 2016 until December numbers patients diagnosed with types CNS (such as...
Background and Purpose— Many patients with acute ischemic stroke are not eligible for thrombolysis or mechanical reperfusion therapies due to contraindications, inaccessible vascular occlusions, late presentation, large infarct core. Sphenopalatine ganglion (SPG) stimulation enhance collateral flow stabilize the blood-brain barrier offers an alternative, potentially more widely deliverable, therapy. Methods— In a randomized, sham-controlled, double-masked trial at 41 centers in 7 countries,...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with predominant progressive degeneration of motor neurons and deficits, but non-motor symptoms (NMS) such as cognitive behavioural deficits are frequent underestimated in current diagnostic pathways. Autonomic dysfunction has occasionally been described, although its frequency relevance unclear. The aim this study was to investigate the role autonomic nervous system ALS using multimodal approach.Thirty-seven patients 40...
Vagus nerve stimulation (VNS) has become a promising therapy especially for drug resistant epilepsy and other pathologies. Side effects or missing therapeutic success are observed due to cuff electrodes that too narrow wide. Preoperative high-resolution ultrasound is used evaluate the size of cervical vagus (CVN) estimate VNS. It remains unclear how precise reflects CVN dimensions, which been objective this study. cross-sections diameters were investigated in 23 sides from 12 bodies, using...
Introduction Venous thromboembolic events (VTEs) like deep vein thrombosis or pulmonary embolism are frequent complications in (neuro) critical ill patients. Anticoagulation for VTE after space-occupying brain infarction is a therapeutic dilemma. The aim of this retrospective study was to investigate the frequency clinically apparent patients with acute ischaemic stroke (AIS) due large vessel occlusion (LVO), its treatment, and rate complications. Methods Patients first AIS LVO were assigned...
Abstract Background The impact of direct oral anticoagulants (DOAC) on haematoma size after intracerebral haemorrhage (ICH) compared to no-anticoagulation is controversial and prospective data are lacking. Methods investigator-initiated, multicentre, RASUNOA-prime study enrolled patients with non-traumatic ICH atrial fibrillation while a DOAC, vitamin K antagonist (VKA) or no anticoagulation (non-OAC). Neuroimaging was reviewed centrally blinded group allocation. Primary endpoint expansion...
Cerebral venous thrombosis (CVT) due to vaccine-induced immune thrombotic thrombocytopenia (VITT) is a severe condition, with high in-hospital mortality rates. Here, we report clinical outcomes of patients CVT-VITT after SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) vaccination who survived initial hospitalization.We used data from an international registry developed CVT within 28 days vaccination, collected until February 10, 2022. VITT diagnosis was classified based on the...
Patients with major depressive disorder (MDD) have an increased risk for cardiac events. This is partly attributed to a disbalance of the autonomic nervous system (ANS) indicated by reduced vagal tone and (relative) sympathetic hyperactivity. However, in most studies, heart rate variability (HRV) was only examined while resting. So far, it remains unclear whether dysbalance ANS patients MDD restricted resting or also evident during parasympathetic activation. The aim this study compare...
After promising results in experimental stroke, normobaric (NBO) or hyperbaric oxygenation (HBO) have recently been discussed as co-medication with tissue plasminogen activator (tPA) for improving outcome. This study assessed the interactions of hyperoxia and tPA, focusing on survival, early functional outcome blood-brain barrier (BBB) integrity following stroke.Rats (n = 109) underwent embolic middle cerebral artery occlusion sham surgery. Animals were assigned to: Control, NBO (60-minute...
Background: Viral meningitis/encephalitis (ME) is a rare but potentially harmful disease. The prompt identification of the respective virus important to guide not only treatment also potential public health countermeasures. However, in about 40% cases, no identified despite an extensive diagnostic workup. aim present study was analyze demographic, seasonal, and routine cerebrospinal fluid (CSF) parameters cases viral ME assess their utility for prediction causative virus. Methods:...
While the concept of Neurovascular Unit (NVU) is increasingly recognized for exploring mechanisms tissue damage in ischemic stroke, immunohistochemical analyses are interest to specifically visualize constituents like endothelium. Changes immunoreactivity have also been discussed reflect functional aspects, e.g., integrity blood-brain barrier (BBB). This study aimed characterize endothelial antigen (EBA) as addressed by antibody SMI-71 a rat model embolic considering FITC-albumin BBB leakage...