Sabine Löffler

ORCID: 0000-0003-3071-6125
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About
Contact & Profiles
Research Areas
  • Anatomy and Medical Technology
  • Innovations in Medical Education
  • Surgical Simulation and Training
  • Emergency and Acute Care Studies
  • Shoulder and Clavicle Injuries
  • Shoulder Injury and Treatment
  • Dental Research and COVID-19
  • Pneumonia and Respiratory Infections
  • Estrogen and related hormone effects
  • Trauma Management and Diagnosis
  • Vagus Nerve Stimulation Research
  • Adipose Tissue and Metabolism
  • Regulation of Appetite and Obesity
  • Esophageal and GI Pathology
  • EEG and Brain-Computer Interfaces
  • Dental Radiography and Imaging
  • Animal Virus Infections Studies
  • Prostate Cancer Diagnosis and Treatment
  • Neurological disorders and treatments
  • Exercise and Physiological Responses
  • Health, psychology, and well-being
  • Orthopedic Infections and Treatments
  • Neonatal and Maternal Infections
  • Knee injuries and reconstruction techniques
  • Osteoarthritis Treatment and Mechanisms

Leipzig University
2015-2025

Medical University of Graz
2015-2023

Panagiotis & Aglaia Kyriakou Children's Hospital
2023

National and Kapodistrian University of Athens
2023

Sotiria General Hospital
2023

Imperial College London
2023

Patan Academy of Health Sciences
2023

Universitätsklinikum Erlangen
2016

Klinik und Poliklinik für Psychotherapie und Psychosomatik
2010-2012

University Hospital Carl Gustav Carus
2012

Thiel‐fixed specimens have outstandingly lifelike visual and haptic properties. However, the original Thiel method is expensive requires an elaborate setup. It therefore of principal interest to modify in order make it available a broader user group. A modified embalming will be described detail compared ethanol‐glycerin fixation with help illustrative examples. The properties, usability for performing histological investigations, costs potential health aspects considered. Tissues fixed...

10.1002/ase.1450 article EN Anatomical Sciences Education 2014-04-04

Abstract Anatomical fixation and conservation are required to prevent specimens from undergoing autolysis decomposition. While is the primary arrest of structures responsible for decomposition, preserves state fixation. Although commonly used, formaldehyde has been classified as carcinogenic humans. For this reason, an adequate substitute was developed. Ethanol‐glycerin thymol described compared with phenol in technical report. The setup, tissue qualities, financial aspects, health concerns...

10.1002/ase.1270 article EN Anatomical Sciences Education 2012-03-20

Vagus nerve stimulation (VNS) has become a well-established therapy for epilepsy and depression, is emerging to treat inflammatory disease, with the cervical vagus (CVN) as major site. CVN morphometries are missing VNS, considering its variability. Morphometric data were obtained from CVNs in 27 cadavers, including branching patterns histology. Cross-sectional area, greater lesser diameters averaged 7.2 ± 3.1 mm2, 5.1 1.5 4.1 1.3 mm, ≤11.0 ≤7.0 ≤5.8 mm 90% of specimens, respectively. Midline...

10.1038/s41598-018-26135-8 article EN cc-by Scientific Reports 2018-05-16

Embalming fixatives such as formaldehyde and phenol have been associated with occupational health hazards. While anatomists aim at replacing these chemicals, this seems presently unfeasible in particular for formaldehyde. Furthermore, fixation protocols usually require well‐equipped facilities highly experienced staff to achieve good results spite of only a minimal use Combining aspects, technique robust enough be carried out by morticians is presented, resulting durable tissues use. An...

10.1002/ase.1933 article EN cc-by-nc-nd Anatomical Sciences Education 2019-11-23

Leptin, the 'obese' protein, is found in cultured granulosa cells derived from human pre-ovulatory follicles. However, occurrence of leptin has not been studied intact ovaries, either normal or polycystic, until now. Paraffin sections 25 ovaries different cycle stages and wedge resections polycystic were investigated by means immunochemistry. Additionally, three available for reverse transcription-polymerase chain reaction analysis. Leptin-positive located pre-antral follicles, distinctly...

10.1093/molehr/7.12.1143 article EN Molecular Human Reproduction 2001-12-01

Vagus nerve stimulation (VNS) has become a promising therapy especially for drug resistant epilepsy and other pathologies. Side effects or missing therapeutic success are observed due to cuff electrodes that too narrow wide. Preoperative high-resolution ultrasound is used evaluate the size of cervical vagus (CVN) estimate VNS. It remains unclear how precise reflects CVN dimensions, which been objective this study. cross-sections diameters were investigated in 23 sides from 12 bodies, using...

10.1038/s41598-023-27894-9 article EN cc-by Scientific Reports 2023-01-17

When conducting biomechanical testing or clinical training using embalmed human soft tissues, it is essential to understand their impact on properties and time dependence. Previous studies have investigated this influence, but specific variations over different embalming durations not been thoroughly addressed date. Ninety-seven iliotibial band specimens were obtained from nine donors. All in ethanol-glycerin for varying durations: one day, eight days, fourteen days. Prior the mechanical...

10.1016/j.jmbbm.2025.106887 article EN cc-by Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials 2025-01-08

<ns3:p>Aim During the COVID-19 pandemic, microscopy course as part of dental medical training in Leipzig, Germany, was offered both purely digitally and with reduced attendance time. The reformed regulations on licensing dentists (ZApprO; „Approbationsordnung für Zahnärzte und Zahnärztinnen“) now also provide necessary legal basis for curricular integration digital teaching formats. Aim this study is detailed evaluation relevant courses resulting design modern training. Methods Evaluation...

10.12688/mep.20580.1 article EN cc-by MedEdPublish 2025-01-09

<ns3:p>Aim During the COVID-19 pandemic, microscopy course as part of dental medical training in Leipzig, Germany, was offered both purely digitally and with reduced attendance time. The reformed regulations on licensing dentists (ZApprO; „Approbationsordnung für Zahnärzte und Zahnärztinnen“) now also provide necessary legal basis for curricular integration digital teaching formats. Aim this study is detailed evaluation relevant courses resulting design modern training. Methods Evaluation...

10.12688/mep.20580.2 article EN cc-by MedEdPublish 2025-02-25

Anatomical dissection is known to serve as an integral tool in teaching gross anatomy, including postgraduate training. A variety of embalming techniques exist, resulting different haptic and optical tissue properties. This study aimed objectify learning outcomes medical student perceptions related the use two widely used techniques, namely Thiel ethanol-glycerin embalming. Between 2020 2022, first- second-year students enrolled course on topographic anatomy participated this study....

10.1002/ase.2306 article EN cc-by-nc Anatomical Sciences Education 2023-06-20

BackgroundStability is regarded as an important factor for proper healing and avoiding secondary dislocation in osteoporotic fractures of the proximal humerus. Several surgical techniques have been proposed treatment, including intramedullary nail osteosynthesis locking plate fixation. This study introduces a novel approach that combines both compares its primary stability with conventional methods.MethodsThe involved 25 humeri two-part fracture models, which were randomly assigned to...

10.1016/j.clinbiomech.2024.106235 article EN cc-by Clinical Biomechanics 2024-03-28

Integration of anatomy and clinical teaching is a theoretical ideal, yet there worldwide paucity such amalgamation. These models provide support for medical trainees, an important element in Germany where orthopedic intern numbers have declined anecdotal evidence suggests disinterest orthopedics. The aim the study was to develop integrated anatomy-surgical course undergraduate training, assess model developed, explore how students perceive orthopedics as career. deliver focusing on...

10.1002/ase.1675 article EN Anatomical Sciences Education 2016-12-21

The tyrosine kinase KIT receptor, the protooncogene CD117, plays a key role in growth and maturation of oocytes follicles. Relevant data are sparse for corpus luteum (CL). We first confirmed presence mRNA protein bovine CL homogenates. then localized KIT-positive (KIT+) cells sections by immunohistochemistry. At stage early development, former theca transforming into capsule/septa showed strong band-like KIT+ immunoresponse. In addition, CD45+ leukocytes septa included subpopulations...

10.1530/rep-07-0236 article EN Reproduction 2007-09-21
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