A5100771423- Drug-Induced Adverse Reactions
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- Urticaria and Related Conditions
- Monoclonal and Polyclonal Antibodies Research
- Dermatology and Skin Diseases
- Mast cells and histamine
- Respiratory and Cough-Related Research
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical studies and practices
- Autoimmune Bullous Skin Diseases
- Inflammatory mediators and NSAID effects
- Immunotherapy and Immune Responses
- Pharmacovigilance and Adverse Drug Reactions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Mycobacterium research and diagnosis
- Immune Cell Function and Interaction
- Tuberculosis Research and Epidemiology
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Pneumocystis jirovecii pneumonia detection and treatment
- Advanced biosensing and bioanalysis techniques
- Antibiotic Resistance in Bacteria
Hospital Regional Universitario de Málaga
2016-2025
Instituto de Investigación Biomédica de Málaga
2016-2025
Universidad de Málaga
2011-2025
Universidade do Estado do Rio de Janeiro
2025
Instituto de Salud Carlos III
2018-2025
Andalusian Centre for Nanomedicine and Biotechnology
2016-2025
United States Army Medical Research Institute of Infectious Diseases
2025
University of Valparaíso
2025
University of Iowa
2025
Pontificia Universidad Católica de Chile
2016-2025
Abstract Skin tests are of paramount importance for the evaluation drug hypersensitivity reactions. Drug skin often not carried out because lack concise information on specific test concentrations. The diagnosis allergy is based history alone, which an unreliable indicator true hypersensitivity.To promote and standardize reproducible testing with safe nonirritant concentrations in clinical practice, E uropean N etwork A cademy llergy C linical I mmunology ( EAACI ) Interest Group Allergy has...
Hypersensitivity reactions to betalactams (BLs) are classified as immediate or nonimmediate. The former usually appear within 1 h of drug‐intake and mediated by specific IgE‐antibodies. Nonimmediate those occurring more than after drug‐intake, they can be T‐cell mediated. diagnostic evaluation allergic BLs has changed over the last 5 years, for several reasons. Major minor determinants no longer commercially available skin testing in many countries. In reactions, sensitivity immunoassays is...
Studies completed to date provide persuasive evidence that placental cell-derived exosomes play a significant role in intercellular communication pathways potentially contribute placentation and development of materno-fetal vascular circulation. The aim this study was establish the gestational-age release profile bioactivity exosome maternal plasma. Plasma samples (n = 20 per pregnant group) were obtained from non-pregnant women first (FT, 6–12 weeks), second (ST, 22–24 weeks) third (TT,...
NSAID-exacerbated respiratory disease (N-ERD) is a chronic eosinophilic, inflammatory disorder of the tract occurring in patients with asthma and/or rhinosinusitis nasal polyps (CRSwNP), symptoms which are exacerbated by NSAIDs, including aspirin. Despite some progress understanding pathophysiology syndrome, affects 1/10 and rhinosinusitis, it remains diagnostic therapeutic challenge. In order to provide evidence-based recommendations for diagnosis management N-ERD, panel international...
Abstract A recent survey of the European Academy Allergy and Clinical Immunology (EAACI) Drug Interest Group (DAIG) on how allergy specialists deal with beta‐lactam (BL) hypersensitivity demonstrated a significant heterogeneity in current practice, suggesting need to review update existing EAACI guidelines order make diagnostic procedures as safe accurate, but also cost‐effective, possible. For this purpose, bibliographic search large studies regarding BL diagnosis was performed by an task...
Abstract Drug hypersensitivity reactions ( DHR s) are common, and the skin is by far most frequently involved organ with a broad spectrum of reaction types. The diagnosis cutaneous s CDHR ) may be difficult because multiple differential diagnoses. A correct classification important for management. With these guidelines, we aim to give precise definitions provide background needed doctors correctly classify .
The first approved COVID-19 vaccines include Pfizer/BioNTech BNT162B2, Moderna mRNA-1273 and AstraZeneca recombinant adenoviral ChAdOx1-S. Soon after approval, severe allergic reactions to the mRNA-based that resolved treatment were reported. Regulatory agencies from European Union, Unites States United Kingdom agree vaccinations are contraindicated only when there is an allergy one of vaccine components or if was a reaction dose. This position paper Academy Allergy Clinical Immunology...
Abstract The exponential growth of precision diagnostic tools, including omic technologies, molecular diagnostics, sophisticated genetic and epigenetic editing, imaging nano‐technologies patient access to extensive health care, has resulted in vast amounts unbiased data enabling in‐depth disease characterization. New endotypes have been identified for various allergic diseases triggered the gradual transition from a description focused on symptoms identifying biomarkers intricate...
Anaphylaxis, which is rare, has been reported after COVID-19 vaccination, but its management not standardized.Members of the European Network for Drug Allergy and Academy Clinical Immunology interested in drug allergy participated an online questionnaire on pre-vaccination screening allergic reactions to vaccines, literature was analysed.No death due anaphylaxis vaccines confirmed scientific literature. Potential allergens, polyethylene glycol (PEG), polysorbate tromethamine are excipients....
In drug hypersensitivity, provocation testing (DPT), also called challenge, is the gold standard for investigation. recent years, risk stratification has become an important tool adjusting diagnostic strategy to perceived risk, whilst still maintaining a high level of safety patient. Skin tests are recommended before DPT but may be omitted in low-risk patients. The task force suggests strict definition such patients children and adults. Based on experience evidence from studies allergy...
We study elastic band gaps in nonhomogeneous periodic finite media. The finite-difference time-domain method is used for the first time field of band-gap materials. It to interpret experimental data two-dimensional systems consisting cylinders fluids (Hg, air, and oil) inserted periodically a slab aluminum host. provides good convergence, can be applied realistic composite slabs, even composites with huge contrast parameters their components, describes well experiments.