A5065292646- Food Allergy and Anaphylaxis Research
- Drug-Induced Adverse Reactions
- Contact Dermatitis and Allergies
- Immunodeficiency and Autoimmune Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Blood disorders and treatments
- Eosinophilic Esophagitis
- Urticaria and Related Conditions
- Platelet Disorders and Treatments
- Mast cells and histamine
- SARS-CoV-2 and COVID-19 Research
- Chronic Lymphocytic Leukemia Research
- COVID-19 Clinical Research Studies
- Blood groups and transfusion
- SARS-CoV-2 detection and testing
- Hemophilia Treatment and Research
- Ocular Diseases and Behçet’s Syndrome
- Intramuscular injections and effects
- Chronic Myeloid Leukemia Treatments
- Cystic Fibrosis Research Advances
- Anesthesia and Sedative Agents
- Enzyme function and inhibition
- Vitamin K Research Studies
Manchester University NHS Foundation Trust
2012-2025
National Health Service
2009-2024
Manchester University
2015-2024
Ospedale Santa Chiara
2024
Aintree University Hospitals NHS Foundation Trust
2024
University of Liverpool
2024
Manchester Royal Infirmary
2018-2021
University of Manchester
2015
Southmead Hospital
2010
North Bristol NHS Trust
2009
The incidence of anaphylaxis might be increasing. Data for fatal are limited because the rarity this outcome.We sought to document trends in admissions and fatalities by age, sex, cause England Wales over a 20-year period.We extracted data from national databases that record hospital caused (1992-2012) crosschecked against prospective registry. We examined time age distribution food, drugs, insect stings.Hospital all-cause increased 615% period studied, but annual fatality rates remained...
Anaphylaxis, which is rare, has been reported after COVID-19 vaccination, but its management not standardized.Members of the European Network for Drug Allergy and Academy Clinical Immunology interested in drug allergy participated an online questionnaire on pre-vaccination screening allergic reactions to vaccines, literature was analysed.No death due anaphylaxis vaccines confirmed scientific literature. Potential allergens, polyethylene glycol (PEG), polysorbate tromethamine are excipients....
The Standards of Care Committee the British Society for Allergy and Clinical Immunology (BSACI) a committee experts key stakeholders have developed this guideline evaluation testing patients with an unsubstantiated label penicillin allergy. is intended UK clinicians who are not trained in allergy or immunology, but wish to develop de-labelling service their patients. It supplement BSACI 2015 "Management other beta-lactams" therefore does detail epidemiology aetiology allergy, as covered...
Abstract Background Acquired angioedema due to C1-inhibitor deficiency (AAE-C1-INH) is very rare compared its prototype, hereditary angioedema. An updated characterisation of the AAE-C1-INH cohort in UK required inform management. Objectives To describe disease burden AAE-C1-INH, long-term prophylaxis (LTP) and clinical, immunochemical treatment profiles AAE-associated diseases UK. Method Retrospective data on 117 patients were collected using a national survey proforma across 25/34 Adult...
This is the second report of United Kingdom Primary Immunodeficiency (UKPID) registry. The registry will be a decade old in 2018 and, as August 2017, had recruited 4758 patients encompassing 97% immunology centres within Kingdom. represents doubling recruitment into since we reported on 2229 included our first 2013. Minimum PID prevalence currently 5·90/100 000 and an average incidence between 1980 2000 7·6 cases per 100 UK live births. Data are presented frequency diseases recorded, disease...
We describe an observational survey of diagnostic pathways in 104 patients attending four specialist allergy clinics the United Kingdom following perioperative hypersensitivity reactions to chlorhexidine reactions. The majority were life-threatening. Men undergoing urological or cardiothoracic surgery predominated. Skin prick testing and specific immunoglobulin (sIg)E most common tests used for diagnosis. Fifty-three per cent diagnoses made on basis a single positive test. Where multiple...
A 25-year-old woman presented with unilateral red eye and visual blur, was found to have panuveitis an inflammatory white mass at the macula, initially presumed be Toxoplasma retinitis. After failure respond, she underwent vitrectomy, which produced Candida albicans . Despite intraocular systemic antifungal treatment, lost all vision in that eye. Two years later, developed hip osteomyelitis leading total replacement also revealing infection. By clinical exome sequencing, then caspase...
Immunologists are increasingly being asked to assess patients with non-classical and secondary antibody deficiency determine their potential need for immunoglobulin replacement therapy (IGRT). Immunoglobulin is a limited, expensive resource no clear guidance exists this broad patient group. The purpose of survey establish what factors influence the decision commence IGRT in adult patients, when diagnostic criteria primary not fulfilled. Under auspices United Kingdom Primary Immunodeficiency...
Currently, there is no guideline to support the use of immunoglobulin replacement therapy (IgRT) in primary and secondary immunodeficiency disorders UK. The UK Primary Immunodeficiency Network (UK-PIN) British Society Immunology (BSI) joined forces address this need. Given paucity evidence, a modified Delphi approach was used covering statements for initiation, monitoring, discontinuation IgRT as well home programme. A group six consultant immunologists three nurse specialists created...
Detailed demographic data on people with hereditary angioedema (HAE) and acquired C1 inhibitor deficiency in the United Kingdom are relatively limited. Better would be beneficial planning service provision, identifying areas of improvement, improving care.To obtain more accurate demographics HAE Kingdom, including treatment modalities services available to patients.A survey was distributed all centers that look after patients collect these data.The identified 1152 HAE-1/2 (58% female 92%...