A5089031473- Immunodeficiency and Autoimmune Disorders
- Blood disorders and treatments
- COVID-19 Clinical Research Studies
- Cystic Fibrosis Research Advances
- Viral Infections and Immunology Research
- Blood groups and transfusion
- Platelet Disorders and Treatments
- Hematopoietic Stem Cell Transplantation
- Viral gastroenteritis research and epidemiology
- Chronic Lymphocytic Leukemia Research
- Gastrointestinal Bleeding Diagnosis and Treatment
- Infective Endocarditis Diagnosis and Management
- Eosinophilic Esophagitis
- Gastrointestinal disorders and treatments
- Immune Cell Function and Interaction
- Thermal Regulation in Medicine
- Pleural and Pulmonary Diseases
- Mechanical Circulatory Support Devices
- Intensive Care Unit Cognitive Disorders
- Streptococcal Infections and Treatments
- Immune responses and vaccinations
- Neonatal and Maternal Infections
- Neurogenetic and Muscular Disorders Research
- Lymphatic Disorders and Treatments
- Respiratory viral infections research
Sheffield Children's NHS Foundation Trust
2024
Newcastle upon Tyne Hospitals NHS Foundation Trust
2021-2024
Royal Victoria Infirmary
2017-2023
Great North Children's Hospital
2017-2023
Newcastle University
2016-2022
Newcastle upon Tyne Hospital
2018-2020
This is the second report of United Kingdom Primary Immunodeficiency (UKPID) registry. The registry will be a decade old in 2018 and, as August 2017, had recruited 4758 patients encompassing 97% immunology centres within Kingdom. represents doubling recruitment into since we reported on 2229 included our first 2013. Minimum PID prevalence currently 5·90/100 000 and an average incidence between 1980 2000 7·6 cases per 100 UK live births. Data are presented frequency diseases recorded, disease...
Abstract The European Society for Immunodeficiencies patient registry (ESID-R), established in 1994, is one of the world’s largest databases on inborn errors immunity (IEI). IEI are genetic disorders predisposing patients to infections, autoimmunity, inflammation, allergies and malignancies. Treatments include antimicrobial therapy, immunoglobulin replacement, immune modulation, stem cell transplantation gene therapy. Data from 194 centers 33 countries capture clinical manifestations...
Summary Immunoglobulin replacement therapy enhances survival and reduces infection risk in patients with agammaglobulinaemia. We hypothesized that despite regular immunoglobulin therapy, some will experience ongoing respiratory infections develop progressive bronchiectasis deteriorating lung function. One hundred thirty-nine (70%) of 199 aged 1–80 years from nine cities the United Kingdom agammaglobulinaemia currently listed on UK Primary Immune Deficiency (UKPID) registry were recruited...
In January 2020, a novel coronavirus was sequenced in China (SARS-CoV-2) and it linked to cases of severe acute respiratory syndrome as part new disease which named COVID-19·1 Its worldwide spread has led the declaration global health emergency by World Health Organization on 30 2020·2 The first COVID case United Kingdom reported February, 6 2020. Since then more than 4 375 800 have been confirmed countrywide 14/04/2021 (https://coronavirus.data.gov.uk/cases). general population, shown that...
Abstract Increasing detections of vaccine-derived poliovirus (VDPV) globally, including in countries previously declared polio free, is a public health emergency international concern. Individuals with primary immunodeficiency (PID) can excrete polioviruses for prolonged periods, which could act as source cryptic transmission viruses potential to cause neurological disease. Here, we report on the detection immunodeficiency-associated VDPVs (iVDPV) from two asymptomatic male PID children UK...
Patients with congenital agammaglobulinemia, characterized by a defect in B lymphocyte differentiation causing alymphocytosis, require life-long IgG replacement. There is scant literature regarding the effectiveness of treatment at preventing mucosal (particularly sinopulmonary tract) infection and whether current management adequately restores "normal" health quality life (QoL). We aimed to document infective episodes pre- post-commencing replacement, determine any change lung function...
The aim of this study is to add the scant literature on congenital pleural effusions aid counselling and clinical management decisions.Retrospective case series 15 years resulting in live birth a single tertiary foetal medicine/neonatal centre North East England.Data were available for 21 infants. Mortality rates 43% overall. All spontaneous resolution occurred within 9 d, active was used where persisted beyond this.Prematurity associated with poor prognosis. Resolution without before day 10...
<h3>ABSTRACT</h3> Supply of immunoglobulin in the UK faces pressures due to increasing demand, cost and variable supply. This paper describes replacement therapy (IGRT) primary immunodeficiency (PID) secondary (SID) assist ongoing planning provision. A retrospective analysis National Immunoglobulin Database UKPID registry was carried out. In total, 3,222 patients are registered as receiving IGRT for immunodeficiencies. Predominately antibody disorders made up largest diagnostic category (61%...
Abstract Since the first clinical description in 1952, immunoglobulin replacement therapy remains mainstay of treatment patients with X-linked agammaglobulinemia (XLA). However, this only replaces IgG isotype and does not compensate for loss Bruton tyrosine kinase non-B-lymphocytes. Patients may still therefore develop complications despite current standard care. Here, we describe an XLA patient persistent chronic norovirus infection, refractory to causing intestinal failure. The underwent...
Cystic fibrosis (CF) is a genetic condition that affects multiple organ systems. Allergic bronchopulmonary aspergillosis (ABPA) well-recognised problem but other allergic conditions are less well documented in CF.To characterise the profile of cohort children with CF, focus on those ABPA.A CF were interviewed and retrospective data collected regarding their histories relevant clinical features.The included 37 median age 9 years (interquartile range: 6-12). There was history ≥1 condition(s)...
This case describes a neonate who presented with spontaneous Clostridium perfringens meningitis and brain abscess. The abscess was drained, the infant completed 6-week course of antibiotics. Throughout this time remained well no need for intensive care. C. central nervous system infections are associated trauma poor outcomes. highlights that spectrum disease can include infection relatively mildly clinical demonstrating importance 16s polymerase chain reaction in culture-negative cases its...
Background and study aims Eosinophilic oesophagitis (EoE) is a common disease with significant impact on physical health quality of life (QoL). Outcomes management vary widely, no agreed UK national guideline. This paper to describe an up-to-date description demographics, clinical spectrum outcomes for paediatric adult patients EoE from the North East England between 2016 2019. Patients methods two large University Hospitals specialist hospital histologically or clinically confirmed were...