A5040265837- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immunodeficiency and Autoimmune Disorders
- Atherosclerosis and Cardiovascular Diseases
- Child and Adolescent Health
- Family and Disability Support Research
- Adolescent and Pediatric Healthcare
- Human Health and Disease
- Cystic Fibrosis Research Advances
- Innovations in Medical Education
- Biomarkers in Disease Mechanisms
- Respiratory viral infections research
- Blood disorders and treatments
- Hematopoietic Stem Cell Transplantation
- Child and Adolescent Psychosocial and Emotional Development
- Bacterial Infections and Vaccines
- IL-33, ST2, and ILC Pathways
- Pneumonia and Respiratory Infections
- Asthma and respiratory diseases
- Infective Endocarditis Diagnosis and Management
- Patient Satisfaction in Healthcare
- Autoimmune and Inflammatory Disorders Research
- Neonatal and Maternal Infections
- Neuroinflammation and Neurodegeneration Mechanisms
- Renal Transplantation Outcomes and Treatments
- Chemotherapy-related skin toxicity
Great North Children's Hospital
2016-2024
Newcastle upon Tyne Hospitals NHS Foundation Trust
2019-2020
Newcastle University
2012-2020
Newcastle upon Tyne Hospital
2020
Royal Victoria Infirmary
2013-2016
The University of Queensland
1976
Reade
1976
Correspondence to: I J Haq iram.haq@newcastle.ac.uk #### What you need to know In 2015, community acquired pneumonia (CAP) accounted for 15% of deaths in children under 5 years old globally and 922 000 all ages.1 It is defined as a clinical diagnosis caused by infection previously healthy child.2 Clinical assessment can be challenging; symptoms vary with age non-specific young children, aetiology often unknown at presentation. This article will provide an update on CAP management...
Abstract This study aimed to identify a risk profile for development of transplant-associated thrombotic microangiopathy (TA-TMA) in children undergoing hematopoietic stem cell transplantation (HSCT). Between 2013 and 2016, 439 underwent 474 HSCTs at 2 supraregional United Kingdom centers. At median 153 days post-HSCT, TA-TMA occurred among 25 441 evaluable cases (5.6%) with no evidence center variation. Sex, underlying disease, intensity the conditioning, total body irradiation–based use...
Paediatric focal intracranial suppurative infections are uncommon but cause significant mortality and morbidity. There no uniform guidelines regarding antibiotic treatment. This study reviewed management in a tertiary healthcare centre the United Kingdom considers suggestions for empirical A retrospective, single-centre cohort review of 95 children (< 18 years age) with infection admitted between January 2001 June 2016 Newcastle upon Tyne, Kingdom. Microbiological profiles regimens were...
Patients with congenital agammaglobulinemia, characterized by a defect in B lymphocyte differentiation causing alymphocytosis, require life-long IgG replacement. There is scant literature regarding the effectiveness of treatment at preventing mucosal (particularly sinopulmonary tract) infection and whether current management adequately restores "normal" health quality life (QoL). We aimed to document infective episodes pre- post-commencing replacement, determine any change lung function...
X-linked chronic granulomatous disease (XL-CGD), a rare primary immunodeficiency due to defect in the gp91phox NADPH oxidase subunit, results recurrent, severe infection, inflammation, and autoimmunity. Patients have an absent, or significantly reduced, neutrophil oxidative burst. Due lyonization, XL-CGD carriers dual population of functional non-functional phagocytes experience range symptoms including increased risk autoimmunity, fatigue, infection. with CGD poorer quality life (QoL) than...
Background: Parents' health-seeking behaviors has changed during the COVID-19 pandemic. Providing parents' guidance in decision-making might improve their confidence to seek timely advice when a child becomes ill. The aim of this study was evaluate 'How recognize if your is seriously ill' leaflet on confidence, behaviors, and usefulness lockdown. Method: A 9-item survey, co-designed with parent advisors, used measuring behavior. Social media for data collection 6-week period (April–June...
Summary The findings of staging laparotomies in 82 patients with Hodgkin's Disease are presented. Sub‐diaphragmatic disease was discovered 30 patients, the spleen being most common site involvement (26 patients). Staging advanced 23 and reduced 3, consequent changes treatment plan these patients. In a further 4 altered by distribution subdiaphragmatic discovered, without any change stage. Lymphangiography found to be an unreliable procedure. This largely due frequent presence areas outside...
<h3>Objectives</h3> Pharyngitis is a common presentation in children with most cases having viral aetiology.<sup>1</sup> Clinical scoring tools such as 'FeverPAIN' can be used to estimate the likelihood of bacterial infection and are often highly sensitive but not very specific well being validated younger children.<sup>2</sup>Group A Streptococcus (GAS) potentially serious pathogen that concerns paediatricians contributes many antibiotic prescriptions for pharyngitis.<sup>2</sup>2022 saw...
Objective: To evaluate the impact of a novel approach to Social Prescribing (SP) embedded within education for primary-school aged children with early social-emotional mental health (SEMH) difficulties in socioeconomically deprived areas Design: Repeated measures Setting: 10 primary schools Patients: 117 7-11 years SEMH Intervention: Children received weekly support Link Worker and attend community assets over 9 months. Main outcome measures: Teacher (T) parent (P) report Strengths...
Abstract Children’s attendances in paediatric emergency departments have fallen precipitously North East England and elsewhere recent months. We analysed data from 3 hospitals to understand which children were not being brought during the COVID-19 ‘lockdown’. In our population there is no evidence of a disproportionate impact on belonging vulnerable sociodemographic groups obvious change illness acuity among those still attending. However we noted marked reduction infectious disease...
<h3>Background and aims</h3> Handover of patients between shifts is an important process, to ensure continuity care that information communicated the appropriate personnel. It should be completed in a timely efficient manner. Interruptions only for emergencies or essential clarification. In large teaching hospital regarding up 80 needs half hour window every morning number subspecialities. Late arrivals delay start this process prolong duration. Frequent interruptions may disrupt process. We...
<h3>Objectives</h3> Prolonged jaundice, defined as jaundice beyond 14 days of life, indicates further investigation to identify pathological causes such biliary atresia and congenital hypothyroidism. The earlier these conditions are identified, the better long-term outcome. At Great North Children's Hospital, an SHO-led clinic runs assess babies in paediatric outpatients; health visitors midwives can refer via telephone on-call SHO. There have been concerns about delays from referral...