A5011838545- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
- Surgical Simulation and Training
- Neurosurgical Procedures and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Spinal Fractures and Fixation Techniques
- Advanced Neuroimaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury Research
- Radiation Dose and Imaging
- Family and Disability Support Research
- Intracranial Aneurysms: Treatment and Complications
- Hospital Admissions and Outcomes
- Pituitary Gland Disorders and Treatments
- Spine and Intervertebral Disc Pathology
- Spinal Dysraphism and Malformations
- Neuroscience and Neuropharmacology Research
- Aortic Disease and Treatment Approaches
- Computational Drug Discovery Methods
- Vascular Malformations Diagnosis and Treatment
- Workplace Health and Well-being
- Parkinson's Disease and Spinal Disorders
- Genetics, Aging, and Longevity in Model Organisms
- Health and Medical Research Impacts
- Healthcare professionals’ stress and burnout
Royal Victoria Infirmary
2012-2024
Newcastle University
2010-2024
Great North Children's Hospital
2019-2023
Newcastle upon Tyne Hospitals NHS Foundation Trust
2014-2020
Royal Children's Hospital
2017
University of Edinburgh
2014
University of Newcastle Australia
2014
University of Aberdeen
2014
Durham University
2014
Addenbrooke's Hospital
2013
To relate neurophysiologic changes after mild/moderate traumatic brain injury to cognitive deficit in a longitudinal diffusion tensor imaging investigation.Fifty-three patients were scanned an average of 6 days postinjury (range = 1-14 days). Twenty-three rescanned 1 year later. Thirty-three matched control subjects recruited. At the time scanning, participants completed testing. Tract-Based Spatial Statistics was used conduct voxel-wise analysis on and explore regressions between metrics...
Uncertainty remains as to the role of decompressive craniectomy (DC) for primary evacuation acute subdural haematomas (ASDH). In 2011, a collaborative group was formed in UK with aim answering following question: "What is clinical- and cost-effectiveness craniectomy, comparison craniotomy adult patients undergoing an ASDH?" The proposed RESCUE-ASDH trial (Randomised Evaluation Surgery Craniectomy Undergoing Evacuation Acute Subdural Haematoma) multicentre, pragmatic, parallel randomised DC...
The increasing utilisation of decompressive craniectomy for traumatic brain injury and stroke has led to an increase in the number cranioplasties undertaken. Cranioplasty is also undertaken following excision tumours originating from or invading skull vault, removal bone flaps due post-operative infection, management rarer causes oedema and/or refractory intracranial hypertension. existing literature which mainly consists single-centre, retrospective studies, shows a significant variation...
Background. Chronic subdural haematoma (CSDH) is a common condition that increases in incidence with rising age. Evacuation of CSDH one the commonest neurosurgical procedures; however optimal peri-operative management, surgical technique, post-operative care and role adjuvant therapies remain controversial. Aim. We propose prospective multi-centre audit order to establish current practices, outcomes national benchmarks for future studies. Methods. Neurosurgical units (NSU) United Kingdom...
Traumatic brain injury (TBI) can result in acute cognitive deficits and diffuse axonal reflected white matter network alterations which may, or not later recover. Our objective is to first characterize the ways networks change after TBI second, investigate if those changes are associated with recovery of deficits. We aim make initial progress discerning relationships between changes, their (dys)functional correlates. analyse longitudinally acquired MRI from 23 patients (two time points: 6...
Clinical research, which is essential for improving patient outcomes, increasingly carried out in the context of networks established between multiple institutions. Research also considered an important component training curricula. The recent successful completion a randomised trial (ROSSINI), was led by general surgical trainees West Midlands Collaborative, has feasibility trainee collaborative research networks. A network neurosurgical UK and Ireland was, therefore, following meeting...
Spondylodiscitis is often iatrogenic in nature. We report the case of a 69-year-old man presenting with spondylodiscitis and associated epidural abscess following transrectal ultrasonography guided prostate biopsy despite ciprofloxacin cover. To our knowledge, this first secondary to fluoroquinolone resistant Escherichia coli.
Summary Cortical circuit activity is controlled by GABA-mediated inhibition in a spatiotemporally restricted manner. Much known about fast GABA currents, B receptor (GABA R) signalling exerts powerful slow that controls synaptic, dendritic and neuronal activity. However, little how Rs contribute to circuit-level over the lifespan of rodents humans. In this study, we quantitatively determine functional contribution R pre- postsynaptic domains rat human cortical principal cells (PC). We find...
Current medicines are ineffective in approximately one-third of people with epilepsy. Therefore, new antiseizure drugs urgently needed to address this problem pharmacoresistance. However, traditional rodent seizure and epilepsy models poorly suited high-throughput compound screening. Furthermore, testing a single species increases the chance that therapeutic compounds act on molecular targets may not be conserved humans. To these issues, we developed pipeline approach using four different...
We report the results from a survey of British Neurosurgical Trainees' Association which aimed to assess current rota patterns and their compliance with government's working time regulations. The questioned whether trainees felt that shift working, imposed as result European directive, is continuing impact on patient care training opportunities in neurosurgery. responses this indicate neurosurgical remain concerned regulations have all facets work: training, work- life balance, provision...
Congenital glioblastomas are rare primary tumours of the central nervous system with poor prognosis if left untreated. We report case a 4-week-old infant such tumour treated by surgical excision and course postoperative chemotherapy. After chemotherapy, patient displayed neurological deterioration follow-up magnetic resonance imaging (MRI) scans revealed no signs recurrence, but showed entrapment significant distension right lateral ventricle. A novel technique contralateral...
OBJECTIVE Perioperative management of hydrocephalus in children with posterior fossa tumors (PFTs) remains challenging. The modified Canadian Preoperative Prediction Rule for Hydrocephalus (mCPPRH) has been previously described as a useful tool predicting which are at higher risk permanent following PFT resection and can be used guiding treatment. aim this study was to externally validate predictive model. METHODS A retrospective review the treated single unit conducted, recording all mCPPRH...
We report two cases of dural arteriovenous fistulae treated endovascularly, where percutaneous venous or arterial access was not suitable. In both cases, a different surgical technique used to allow transcranial cannulation the appropriate sinus varix gain and occlude fistula.
Objectives The most commonly used summary metric in neuroimaging is the mean value, but this pays little attention to shape of data distribution and can therefore be insensitive subtle changes that alter distribution. Methods We propose a distributional-based called normalized histogram similarity measure (HSM) for characterization quantitative images. applied HSM magnetic resonance imaging T1 relaxation 44 patients with mild traumatic brain injury compared 43 age-matched controls. Results...
Maintenance of on-call referrals databases is on the rise in neurosurgical units across UK and helps provide data to estimate workload. We hypothesize that these underestimate workload propose use number telephone calls registrar as an easily obtainable valid measure workload.Data were obtained from a database maintained completed by registrars hospital switchboard logs. Data analysed using JMP 8.0.2 (SAS Institute, Cary, NC).We found large degree disparity between phone recorded referrals....