A5026859355- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebral Palsy and Movement Disorders
- Traumatic Brain Injury Research
- Epilepsy research and treatment
- Cardiac Arrest and Resuscitation
- Metabolism and Genetic Disorders
- Functional Brain Connectivity Studies
- Infant Development and Preterm Care
- Neonatal and fetal brain pathology
- Family and Disability Support Research
- Blood Coagulation and Thrombosis Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Acute Ischemic Stroke Management
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Diet and metabolism studies
- Multiple Sclerosis Research Studies
- Child and Adolescent Health
- Neurogenetic and Muscular Disorders Research
- Neonatal Respiratory Health Research
- Autoimmune Neurological Disorders and Treatments
- Semantic Web and Ontologies
- Childhood Cancer Survivors' Quality of Life
- Neural dynamics and brain function
- Cardiac, Anesthesia and Surgical Outcomes
Newcastle University
2016-2025
University College London
2020-2024
Ballarat Health Services
2013-2024
Newcastle upon Tyne Hospitals NHS Foundation Trust
2010-2024
Royal Victoria Infirmary
2007-2021
Great North Children's Hospital
2013-2021
Translational Research Institute
2020
Clinical Research Institute
2020
University of Newcastle Australia
2020
Urological Society of Australia and New Zealand
2019
Glucose transporter-1 deficiency syndrome is caused by mutations in the SLC2A1 gene majority of patients and results impaired glucose transport into brain. From 2004–2008, 132 requests for mutational analysis were studied automated Sanger sequencing multiplex ligation-dependent probe amplification. Mutations detected 54 (41%) subsequently three clinically affected family members. In these 57 we identified 49 different mutations, including six multiple exon deletions, known 37 novel (13...
<h3>Importance</h3> Myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) are consistently identified in a range of demyelinating disorders adults and children. Current therapeutic strategies largely center specific, no treatments have been formally evaluated. <h3>Objective</h3> To examine the clinical phenotypes, treatment responses, outcomes children with relapsing MOG-Ab–associated disease. <h3>Design, Setting, Participants</h3> This study prospectively collected demographic, clinical,...
The aim of the paper is to explore issues involved in measuring children's participation.The concept participation as encapsulated International Classification Functioning, Disability and Health (ICF) discussed it applies children. essential components any measure are outlined, including for normal development survival, leisure activities, educational participation. Some existing instruments briefly reviewed terms their coverage adequacy approach measurement.Key regarding content an adequate...
Background and Purpose— Published cohorts of children with arterial ischemic stroke (AIS) in the 1990s to early 2000s reported 5-year cumulative recurrence rates approaching 20%. Since then, utilization antithrombotic agents for secondary prevention has increased. We sought determine predictors recurrent current era. Methods— The Vascular Effects Infection Pediatric Stroke (VIPS) study enrolled 355 AIS at 37 international centers from 2009 2014 followed them prospectively stroke. Index...
Background and Purpose— Although arteriopathies are the most common cause of childhood arterial ischemic stroke, strongest predictor recurrent they difficult to diagnose. We studied role clinical data follow-up imaging in diagnosing cerebral cervical arteriopathy children with stroke. Methods— Vascular effects infection pediatric an international prospective study, enrolled 355 cases stroke (age, 29 days 18 years) at 39 centers. A neuroradiologist neurologist independently reviewed vascular...
Minor infection can trigger adult arterial ischemic stroke (AIS) and is common in childhood. We tested the hypotheses that transiently increases risk of AIS children, regardless subtype, while vaccination against protective.The Vascular Effects Infection Pediatric Stroke study an international case-control prospectively enrolled 355 centrally confirmed cases (29 days-18 years old) 354 stroke-free controls. To determine prior exposure to infections vaccines, we conducted parental interviews...
The principal strategy for managing head injury is to reduce the frequency and severity of secondary brain insults from intracranial pressure (ICP) cerebral perfusion (CPP), hence improve outcome. Precise critical threshold levels have not been determined in injured children.
1. This study is concerned with the supply of metabolic substrates for neuronal metabolism. Experiments were carried out to investigate whether mechanisms demonstrated in cultured astrocytes also occurred vivo; these cAMP‐mediated breakdown glycogen and glutamate uptake‐stimulated release lactate. 2. In vivo microdialysis was used freely moving rats. Lactate glucose dialysate assayed using enzyme‐based on‐line assays. Drugs given locally through dialysis probe. Regional cerebral blood flow...
Personalized medicine requires that treatments adapt to not only the patient but also changing factors within each individual. Although epilepsy is a dynamic disorder characterized by pathological fluctuations in brain state, surprisingly little known about whether and how seizures vary same patient. We quantitatively compared within-patient seizure network evolutions using intracranial electroencephalographic (iEEG) recordings of over 500 from 31 patients with focal (mean 16.5 per patient)....
Antibodies to myelin oligodendrocyte glycoprotein (MOG-Ab) have recently been reported in patients with encephalitis who do not fulfill criteria for acute disseminated encephalomyelitis (ADEM). We evaluated a cohort of these children and compared them ADEM.
A prospective study of the families young severely disabled children applying to a non‐governmental organization for financial support examined respective contributions child's intrinsic impairment and family's environment their participation. The population comprised 600 median age 2 years 8 months (range 1y‐12y 1mo), whom 46% had autistic or severe behaviour difficulties, 12% other learning disabilities, 6.8% cerebral palsy, 10% non‐neurological causes disability. Intrinsic was measured...
Background and Purpose— Among children with arterial ischemic stroke (AIS), those arteriopathy have the highest recurrence risk. We hypothesized that progression is an inflammatory process biomarkers would predict recurrent AIS. Methods— In international study of childhood AIS, we selected cases classified into 1 3 most common AIS causes: definite arteriopathic (n=103), cardioembolic (n=55), or idiopathic (n=78). measured serum concentrations high-sensitivity C-reactive protein, amyloid A,...
To compare the real-world effectiveness of newer disease-modifying therapies (DMTs) vs injectables in children with relapsing-remitting multiple sclerosis (RRMS).In this retrospective, multicenter study, from UK Childhood Inflammatory Demyelination Network, we identified RRMS receiving DMTs January 2012 to December 2018. Clinical and paraclinical data were retrieved medical records. Annualized relapse rates (ARRs) before on treatment, time relapse, new MRI lesions, change Expanded Disability...