A5074905979- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Hereditary Neurological Disorders
- Autoimmune and Inflammatory Disorders Research
- Lipid metabolism and disorders
- Childhood Cancer Survivors' Quality of Life
- Herpesvirus Infections and Treatments
- Retinal and Optic Conditions
- Dermatology and Skin Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroinflammation and Neurodegeneration Mechanisms
- Gut microbiota and health
- 14-3-3 protein interactions
- Immunotherapy and Immune Responses
- Clostridium difficile and Clostridium perfringens research
- Inflammasome and immune disorders
- Urinary Bladder and Prostate Research
- Autoimmune Neurological Disorders and Treatments
- Protein Tyrosine Phosphatases
- Polyomavirus and related diseases
- Axon Guidance and Neuronal Signaling
- Rheumatoid Arthritis Research and Therapies
- Cerebrospinal fluid and hydrocephalus
- Tryptophan and brain disorders
Erasmus MC
2015-2022
Leiden University Medical Center
2020
Erasmus University Rotterdam
2015-2019
University Hospital of Basel
2019
University College London
2017
National Hospital for Neurology and Neurosurgery
2017
Erasmus MC - Sophia Children’s Hospital
2017
Great Ormond Street Hospital
2017
Amsterdam UMC Location University of Amsterdam
2015
Sint Lucas Andreas Hospital
2015
<h3>Importance</h3> Myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) are consistently identified in a range of demyelinating disorders adults and children. Current therapeutic strategies largely center specific, no treatments have been formally evaluated. <h3>Objective</h3> To examine the clinical phenotypes, treatment responses, outcomes children with relapsing MOG-Ab–associated disease. <h3>Design, Setting, Participants</h3> This study prospectively collected demographic, clinical,...
<h3>Importance</h3> In 2017, the International Panel on Diagnosis of Multiple Sclerosis revised McDonald 2010 criteria for diagnosis multiple sclerosis (MS). The new are easier to apply and could lead more earlier diagnoses. It is important validate these globally their accuracy in clinical practice. <h3>Objective</h3> To evaluate diagnostic 2017 vs prediction clinically definite MS patients with a typical isolated syndrome (CIS). <h3>Design, Setting Patients</h3> A total 251 at Erasmus MC,...
Background and purpose Neuromyelitis optica spectrum disorders (NMOSDs) are a group of rare inflammatory demyelinating the central nervous system. The identification specific antibodies directed to aquaporin 4 (AQP4‐IgG) led distinction from multiple sclerosis. However, up 25% clinically diagnosed NMO patients seronegative for AQP4‐IgG. A subgroup these might be identified by myelin oligodendrocyte glycoprotein (MOG‐IgG). Our objective was investigate whether clinical characteristics differ....
Acquired demyelinating syndromes (ADS) are immune-mediated disorders of the central nervous system in children. A nationwide, multicentre and prospective cohort study was initiated Netherlands 2006, with a reported ADS incidence 0.66/100,000 per year MS 0.15/100,000 period between 2007 2010. In this study, we provide an update on long-term follow-up Netherlands. Children < 18 years first attack demyelination were included consecutively from January 2006 to December 2016. Diagnoses based...
<h3>Objective</h3> To investigate the possible human leukocyte antigen (HLA) association of both myelin oligodendrocyte glycoprotein (MOG-IgG)-associated diseases (MOGAD) and aquaporin-4 antibody (AQP4-IgG)-positive neuromyelitis optica spectrum disorders (NMOSDs) in Dutch population with European ancestry to clarify similarities or differences immunogenetic background diseases. <h3>Methods</h3> Blood samples from patients national MS/NMOSD expert clinic were tested for MOG-IgG AQP4-IgG...
To investigate whether staff radiologists working in nonacademic hospitals can adequately rule out subarachnoid hemorrhage (SAH) on head CT <6 hours after headache onset.In a multicenter, retrospective study, we studied consecutive series of patients presenting with acute to 11 hospitals. Inclusion criteria were (1) normal level consciousness without focal deficits, (2) onset and reported negative for the presence SAH by radiologist, (3) subsequent CSF spectrophotometry. Two...
Acute disseminated encephalomyelitis followed by optic neuritis (ADEM-ON) is a rare demyelinating syndrome that different from multiple sclerosis and neuromyelitis optica spectrum disorder. The aim of this study was to describe the disease course, treatment response outcome children with ADEM-ON.Children <18 years age were identified six countries EU Paediatric Demyelinating Disease Consortium. Patients fulfilled diagnostic criteria for ADEM at least one ON. Anti-myelin oligodendrocyte...
<h3>Objective</h3> To compare the diagnostic accuracy of McDonald 2017 vs 2010 criteria to predict a second attack MS (clinically definite [CDMS]) at first acquired demyelinating syndromes (ADS). <h3>Methods</h3> One hundred sixty-four children (aged <18 years) with an incident ADS were included in prospective multicenter study between June 2006 and December 2016. Brain (and spinal if available) MRI was performed ≤3 months after symptom onset. Sensitivity, specificity, positive predictive...
Background: A promising biomarker for axonal damage early in the disease course of multiple sclerosis (MS) is neurofilament light chain (NfL). It unknown whether NfL has same predictive value MS diagnosis children as adults. Objective: To explore levels cerebrospinal fluid (CSF) paediatric and adult clinically isolated syndrome (CIS) patients. Methods: total 88 65 patients with a first attack demyelination were included followed (mean follow up-time adults: 62.8 months (standard deviation...
<h3>Objective</h3> To explore the correlation between serum and CSF neurofilament light chain (NfL) association of NfL levels future disease activity in pediatric patients with a first attack acquired demyelinating syndromes (ADS). <h3>Methods</h3> In total, 102 children <18 years CNS demyelination 23 age-matched controls were included. Clinically definite multiple sclerosis (CDMS) was set as an endpoint for analysis. tested by commercially available ELISA (UmanDiagnostics); (sNfL) Simoa...
Fatigue and physical impairments are a major concern in children with multiple sclerosis (MS) after acute disseminated encephalomyelitis (post-ADEM). We here aimed to evaluate the interaction between fatigue, exercise capacity, motor performance, neurological status, quality of life (HRQoL).In this cross-sectional study, data 38 (MS n = 22, post-ADEM 16), aged 4-17 years attending our national pediatric MS center, were studied. was measured Pediatric Quality Life Multidimensional Scale,...
Neuromyelitis optica (NMO) is a rare autoimmune disease affecting the optic nerves and spinal cord. In majority of NMO patients anti-aquaporin-4 antibodies (AQP4-IgG) are detected. Here we assessed nationwide incidence AQP4-IgG-seropositive spectrum disorders (NMOSD) in Netherlands based on results one central laboratory. Data were collected since introduction highly sensitive cell-based assay for six consecutive years. Samples from 2795 individual have been received; them 94 (3.4%)...
Background: Cerebrospinal fluid (CSF) levels of T-cell activation marker soluble CD27 (sCD27) are associated with subsequent disease activity after a first attack suspected MS in adults. The predictive value for course children acquired demyelinating syndromes (ADS) is unknown. Objectives: To assess the sCD27 clinically definite multiple sclerosis (CDMS) diagnosis childhood ADS. Methods: Children <18 years event were prospectively included and followed. Soluble was determined CSF using an...
Background and purpose Clinically isolated syndrome ( CIS ) is a first demyelinating event of the central nervous system can be single event. After CIS, chronic disease course with ongoing inflammation relapses might occur, resulting in diagnosis multiple sclerosis MS ). As yet, there has been no prospective exploration whether children adults have same course. Methods Patients , whose age ranged from 1 to 50 years, were prospectively followed. We divided patients into three different...
It may be difficult for clinicians to estimate the prognosis of pediatric acute transverse myelitis (ATM). The aim this study was define prognostic factors relapsing disease and poor outcome in ATM.This prospective cohort included 49 children, 18 boys 31 girls (median age 13.1 years, IQR 6.5-16.2) with a first episode ATM. Factors associated (Expanded Disability Status Scale (EDSS) ≥ 4) were assessed during median follow-up 37 months (IQR 18-75).In total, 14 patients (29%) experienced 1...
Neurogenic lower urinary tract dysfunction (LUTD) in multiple sclerosis (MS) is highly prevalent adults, but has not previously been described paediatric MS. A total of 24 consecutive children with newly diagnosed MS were prospectively assessed for bladder and bowel problems early after diagnosis. Five (21%) showed LUTD during assessment. One these patients did report voiding complaints. This high prevalence indicates that all recently should be evaluated their disease treated order to...
Gut microbiota dysbiosis may lead to proinflammatory conditions contributing multiple sclerosis (MS) etiology. Pediatric-onset MS patients are close biological disease onset and less exposed confounders. Therefore, this study investigated gut composition functional pathways in pediatric-onset MS, compared monophasic acquired demyelinating syndromes (mADS) healthy controls (HCs).Pediatric participants were selected from the Dutch national prospective cohort including ADS HCs <18 years old....
Background: Pediatric-onset multiple sclerosis (POMS) represents the earliest stage of disease pathogenesis. Investigating cerebrospinal fluid (CSF) proteome in POMS may provide novel insights into early MS processes. Objective: To analyze CSF obtained from children at time initial central nervous system (CNS) acquired demyelinating syndrome (ADS), to compare those subsequently ascertained as having versus monophasic (mADS). Methods: Patients were selected two prospective pediatric ADS...
To uncover how naive B-cell development is functionally related to auto-IgG serostatus, steroid treatment and relapse occurrence in neuromyelitis optica spectrum disorder (NMOSD).