A5061377933- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Autoimmune Neurological Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Infectious Encephalopathies and Encephalitis
- Genetics and Neurodevelopmental Disorders
- Epilepsy research and treatment
- Metabolism and Genetic Disorders
- RNA regulation and disease
- Bacterial Infections and Vaccines
- interferon and immune responses
- Diet and metabolism studies
- Herpesvirus Infections and Treatments
- Protein Tyrosine Phosphatases
- Acute Lymphoblastic Leukemia research
- Neurogenesis and neuroplasticity mechanisms
- Immunodeficiency and Autoimmune Disorders
- Hereditary Neurological Disorders
- Cytomegalovirus and herpesvirus research
- CNS Lymphoma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Mycobacterium research and diagnosis
- Polyomavirus and related diseases
- Myasthenia Gravis and Thymoma
Great Ormond Street Hospital
2016-2025
University College London
2016-2025
National Health Service
2010-2024
University Hospitals Sussex NHS Foundation Trust
2024
University Hospital Southampton NHS Foundation Trust
2024
Queen Mary University of London
2024
Tongji Hospital
2024
Vanderbilt University Medical Center
2024
National Hospital for Neurology and Neurosurgery
2017-2024
Mayo Clinic
2024
See de Seze (doi:10.1093/brain/awx292) for a scientific commentary on this article. A condition associated with an autoantibody against MOG has been recently recognized as new inflammatory disease of the central nervous system, but course and disability outcomes are largely unknown. In study we investigated clinical characteristics MOG-antibody large cohort patients from UK. We obtained demographic data 252 UK positive serum immunoglobulin G1 antibodies tested by Autoimmune Neurology Group...
Neurological manifestations have been reported in adults with coronavirus disease 2019 (COVID-19), which is caused by the highly pathogenic virus severe acute respiratory syndrome 2 (SARS-CoV-2).To report neurological of children COVID-19.In this case-series study, patients younger than 18 years who presented SARS-CoV-2 infection and symptoms to Great Ormond Street Hospital for Children (London, UK) between March 1, 2020, May 8, were included after was confirmed either a quantitative reverse...
<h3>Objective:</h3> To assess the utility and safety of rituximab in pediatric autoimmune inflammatory disorders CNS. <h3>Methods:</h3> Multicenter retrospective study. <h3>Results:</h3> A total 144 children adolescents (median age 8 years, range 0.7–17; 103 female) with NMDA receptor (NMDAR) encephalitis (n = 39), opsoclonus myoclonus ataxia syndrome 32), neuromyelitis optica spectrum 20), neuropsychiatric systemic lupus erythematosus 18), other neuroinflammatory 35) were studied. Rituximab...
Pyridoxine-dependent epilepsy was recently shown to be due mutations in the ALDH7A1 gene, which encodes antiquitin, an enzyme that catalyses nicotinamide adenine dinucleotide-dependent dehydrogenation of l-α-aminoadipic semialdehyde/l-Δ1-piperideine 6-carboxylate. However, whilst this is a highly treatable disorder, there general uncertainty about when consider diagnosis and how test for it. This study aimed evaluate use measurement urine semialdehyde/creatinine ratio mutation analysis...
To report the clinical and investigative features of children with a diagnosis probable autoimmune encephalopathy, both without antibodies to central nervous system antigens.Patients encephalopathy plus one or more neuropsychiatric symptoms, seizures, movement disorder cognitive dysfunction, were identified from 111 paediatric serum samples referred five tertiary neurology centres Oxford for antibody testing in 2007-2010. A blinded review panel 48 patients encephalitis whose are described....
To determine whether myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) were predictive of a demyelination phenotype in children presenting with acquired demyelinating syndrome (ADS).Sixty-five first episode ADS (12 acute disseminated encephalomyelitis, 24 optic neuritis, 18 transverse myelitis, 11 other clinically isolated syndrome) identified from 2 national programs the United Kingdom and France. Acute serum samples tested for MOG-Abs by cell-based assay. Antibodies used to predict...
To establish whether children with relapsing acquired demyelinating syndromes (RDS) and myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) show distinctive clinical radiologic features to generate a diagnostic algorithm for the main RDS use.A panel reviewed characteristics, MOG-Ab aquaporin-4 (AQP4) Ab, intrathecal oligoclonal bands, Epstein-Barr virus serology results of 110 RDS. A neuroradiologist blinded diagnosis scored MRI scans. Clinical, radiologic, serologic tests were...
Longer-term outcomes and risk factors associated with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are not well established.To investigate longer-term of relapse this among patients MOGAD.This large, single-nation, prospective cohort study was conducted 276 MOGAD at 5 health care centers in the UK. Data from January 1973 to March 2020 were collected 146 Oxford its outreach sites, 65 Liverpool, 32 a children's hospital Birmingham, 22 London, 11 Cardiff, Wales....
Knowledge of the evolution CNS demyelinating lesions within attacks could assist diagnosis. We evaluated intra-attack lesion dynamics in patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) vs multiple sclerosis (MS) and aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorder (AQP4+NMOSD).
Objective.. To document the long-term outcome of 83 children with difficult-to-control seizures who were enrolled prospectively in a study efficacy ketogenic diet and had remained on for 1 year.Methods.. A total 150 consecutive entered into diet's tolerability. Three to 6 years after initiation, all families sent survey inquiring about their child's current health status, seizure frequency, anticonvulsant medications. They asked experience reasons discontinuation. Several telephone attempts...
Genetic defects in the IFN-γ response pathway cause unique susceptibility to intracellular pathogens, particularly mycobacteria, but are rare and do not explain mycobacterial disease majority of affected patients. We postulated that acquired macrophage activation by may a similar immunological phenotype thus occurrence disseminated infections some patients without identifiable immune deficiency. Macrophage production were studied whole blood PBMCs 3 with severe, unexplained nontuberculous...
Objective: Changing trends in multiple sclerosis (MS) epidemiology may first be apparent the childhood population affected with onset acquired demyelinating syndromes (ADSs). We aimed to determine incidence, clinical, investigative and magnetic resonance imaging (MRI) features of central nervous system ADSs British Isles for time. Methods: conducted a active surveillance study. All paediatricians, ophthalmologists ( n = 4095) were sent monthly reporting cards (September 2009–September 2010)....
Aim Our objectives were to evaluate the utility of measuring myelin oligodendrocyte glycoprotein ( MOG ) and aquaporin‐4 AQP 4) antibodies (Ab) in clinical practice describe their associated neurological phenotypes children. Method Between 2012 2017, 371 children with suspected acquired demyelinating syndromes ADS seen three tertiary centres tested for ‐Ab 4‐Ab. Medical notes retrospectively reviewed, demographic data compiled. Clinical phenotyping was performed blinded antibody results....
Aim To review the demographics and clinical paraclinical parameters of children with myelin oligodendrocyte glycoprotein ( MOG ) antibody‐associated relapsing disease. Method In this UK ‐based, multicentre study, 31 disease were studied retrospectively. Results Of studied, 14 presented acute disseminated encephalomyelitis ADEM ); they younger (mean 4.1y) than remainder 8.5y) who optic neuritis and/or transverse myelitis p <0.001). Similarly, had an abnormal brain magnetic resonance...
To report the clinical and radiologic findings of children with NMDA receptor (NMDAR) antibodies white matter disorders.Ten significant involvement, or without anti-NMDAR encephalitis, were identified from 46 consecutive NMDAR antibody-positive pediatric patients. Clinical neuroimaging features reviewed treatment outcomes neurologic syndromes evaluated.THREE DISTINCT CLINICORADIOLOGIC PHENOTYPES WERE RECOGNIZED: brainstem encephalitis (n = 3), leukoencephalopathy following herpes simplex...