A5036952718- Pharmaceutical studies and practices
- Child and Adolescent Health
- Pharmaceutical Economics and Policy
- Pediatric Pain Management Techniques
- Anesthesia and Sedative Agents
- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Pharmaceutical Practices and Patient Outcomes
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacovigilance and Adverse Drug Reactions
- Health Systems, Economic Evaluations, Quality of Life
- Ethics and Legal Issues in Pediatric Healthcare
- Intensive Care Unit Cognitive Disorders
- Childhood Cancer Survivors' Quality of Life
- Patient Safety and Medication Errors
- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Metabolism and Genetic Disorders
- Adolescent and Pediatric Healthcare
- Pneumonia and Respiratory Infections
- Pharmaceutical Quality and Counterfeiting
- Neonatal and fetal brain pathology
- Cystic Fibrosis Research Advances
- Poisoning and overdose treatments
- Anesthesia and Neurotoxicity Research
University of Nottingham
2016-2025
Derbyshire Children's Hospital
2014-2023
University of Derby
1998-2022
Lifespan
2022
Royal Derby Hospital
2014-2020
United Nations Industrial Development Organization
2017
Boston Children's Hospital
1992-2012
Routledge (United Kingdom)
2010
Royal Manchester Children's Hospital
2007
Mario Negri Institute for Pharmacological Research
1999-2004
To determine the incidence of adverse drug reactions (ADRs) to unlicensed and off-label drugs used in paediatric inpatients, we carried out prospective surveillance on five different wards a regional children's hospital for 13 wk. Comparison use each with its summary product characteristics was made whether an or manner. The presence ADR determined using previously defined criteria. In total, 4455 courses were administered 936 patients 1046 admissions. 507 (48%) admissions, received one more...
To determine the extent of use in children hospital drugs that are not specifically licensed for (unlicensed) and used outside terms their product licence apply to indication, age, dose, or route administration (off label).Prospective study administered on paediatric medical surgical wards 13 weeks.Regional children's hospital.Paediatric inpatients wards.Comparison each drug with its whether was an unlicensed off label manner.2013 courses were 609 patients 707 admissions. 506 (25%)...
To determine the incidence of adverse drug reactions (ADRs) to unlicensed and off‐label drugs used in paediatric inpatients, we carried out prospective surveillance on five different wards a regional children's hospital for 13 wk. Comparison use each with its summary product characteristics was made whether an or manner. The presence ADR determined using previously defined criteria. In total, 4455 courses were administered 936 patients 1046 admissions. 507 (48%) admissions, received one more...
To determine the extent of use drugs that are either not licensed (unlicensed), or outside terms their product licence (off label) in a neonatal intensive care unit.A prospective study was conducted over 13 weeks.455 prescription episodes were administered to 70 babies. 63 (90%) patients given drug unlicensed used an off label way. 54.7% label, many for more than one reason, and 9.9% (45) unlicensed; 35.4% (161) licensed.The seems be far greater other paediatric settings. This highlights...
SUMMARY Lorazepam was compared with diazepam for the treatment of acute convulsions and status epilepticus in 102 children a prospective, open, ‘odd even dates’ trial. Convulsions were controlled 76 per cent patients treated single dose lorazepam 51 diazepam. Significantly fewer required additional anticonvulsants to terminate seizure. Respiratory depression occurred 3 lorazepam‐treated 15 diazepam‐treated patients. No patient who received admission intensive care unit either respiratory or...
Immune cells rely on the transcription factor NFAT5 to adapt hypertonic stress. The hypertonicity-dependent role of in T vivo remains unclear because mouse models deficiency have produced substantially different cell phenotypes. In this study, we analyzed compartment NFAT5-null and cell-specific knockout mice. We found that mice had constitutive, pronounced hypernatremia suffered a severe immunodeficiency, with lymphopenia, altered CD8 naive/memory homeostasis, inability reject allogeneic...
To determine the nature and number of suspected adverse drug reactions (ADRs) associated with fatal outcomes in children reported through yellow card scheme.All reports ADRs a outcome received by UK Committee on Safety Medicines its Yellow Card Scheme from 1964 until December 2000 were reviewed. Reports vaccines overdose excluded. The medicine, date report, diagnosis, ADR, age child analysed. No formal causality assessment was performed.There 331 deaths 390 medicines for aged 16 years or...
There has been a recent increase in the number of reported cases acute renal failure (ARF) cystic fibrosis (CF). A case-control study was conducted to determine factors which are associated with an increased risk ARF.24 confirmed ARF were identified patients CF from 20 UK centres presenting between 1997 and 2004. Using database, sex- age-matched controls identified. Risk analysed by conditional logistic regression Mantel-Haenszel analysis.21 24 had received aminoglycoside at time their...
Fifty‐three critically ill infants and children received midazolam as sedation in a regional intensive care unit. Assessment of the level was carried out at regular intervals on withdrawal midazolam. Forty‐nine patients were fully alert within 4 h being stopped. Four took from 6 to 1 week become alert. had abnormal behaviour highly suggestive withdrawal. The onset 12 discontinuation duration ranged 3 week. One child paradoxical reaction overall incidence adverse effects studied 17%. No...