A5036347835- Prion Diseases and Protein Misfolding
- Multiple Sclerosis Research Studies
- Cerebral Venous Sinus Thrombosis
- Hepatocellular Carcinoma Treatment and Prognosis
- T-cell and Retrovirus Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Corneal Surgery and Treatments
- Visual perception and processing mechanisms
- Systemic Lupus Erythematosus Research
- Head and Neck Surgical Oncology
- Neurological diseases and metabolism
- Renal cell carcinoma treatment
- Peripheral Neuropathies and Disorders
- Ocular Surface and Contact Lens
- Neurosurgical Procedures and Complications
- HIV/AIDS Impact and Responses
- Myasthenia Gravis and Thymoma
- Glaucoma and retinal disorders
- Veterinary Oncology Research
- Head and Neck Cancer Studies
- Syphilis Diagnosis and Treatment
- Adenosine and Purinergic Signaling
- Reproductive tract infections research
- Ocular Infections and Treatments
- Music History and Culture
University Hospitals Sussex NHS Foundation Trust
2016-2024
National Health Service
2022-2023
Biocompatibles (United Kingdom)
2019-2022
Sydney Children’s Hospitals Network
2021
University of Glasgow
2009-2017
Nova Southeastern University
2016
Shirley Oaks Hospital
2015
Southern General Hospital
2005-2013
Institute of Neurological Sciences
2006-2013
University of Minnesota
2012-2013
Longer-term outcomes and risk factors associated with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are not well established.To investigate longer-term of relapse this among patients MOGAD.This large, single-nation, prospective cohort study was conducted 276 MOGAD at 5 health care centers in the UK. Data from January 1973 to March 2020 were collected 146 Oxford its outreach sites, 65 Liverpool, 32 a children's hospital Birmingham, 22 London, 11 Cardiff, Wales....
To investigate the potential risk factors for variant Creutzfeldt-Jakob disease (VCJD) in United Kingdom.Definite and probable vCJD cases (n = 136) were residing Great Britain at onset, referred between May 1995 November 2003. Control subjects 922) recruited 2002 2003, from 100 randomly selected geographical clusters sampled to represent distribution of vCJD.Reported frequent consumption beef products thought likely contain mechanically recovered or head meat, both, including burgers meat...
Variant Creutzfeldt-Jakob disease (vCJD), a novel form of human prion disease, was recognized in 1996. The affected younger cohort than sporadic CJD, and the early clinical course dominated by psychiatric sensory symptoms. In an attempt to aid diagnosis establish standardization between surveillance networks, diagnostic criteria were established. These devised from features small number cases modified 2000 as phenotype Since then, only minor changes have been introduced; revalidation current...
Objective Factors leading patients with head and neck cancer (HNCA) to seek radiation or chemoradiation in an academic center versus the community are incompletely understood, as effects of site treatment on completion survival. Study Design Historical cohort study. Setting Tertiary center, practices. Methods A historical study was completed mucosal HNCA identified by International Classification Disease, Ninth Revision ( ICD‐9 ) codes receiving consultation at authors’ institution from 2003...
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) can be monophasic or relapsing, with early relapse being a feature. However, the relevance of on longer-term risk is unknown. Here, we investigate whether relapses increase in patients MOGAD.
The Heidenhain variant of sporadic Creutzfeldt-Jakob disease (sCJD) is commonly understood to represent cases with early, prominent visual complaints. term clarified those who present isolated symptoms. This group may pose diagnostic difficulties and often ophthalmologists where they undergo needless invasive procedures.A retrospective review 594 pathologically proved sCJD referred the UK National CJD Surveillance Unit over a 15 year period identify cases.22 had symptoms at onset mean...
<b>Objective:</b> To determine the frequency, in UK, of sporadic Creutzfeldt–Jakob Disease (sCJD) with a cerebellar ataxic onset, and to describe clinical features syndrome. <b>Methods:</b> A retrospective review autopsy-proved cases sCJD 1990–2005, identifying those presenting without early cognitive decline. <b>Results:</b> 29 618 (5%) patients had an isolated onset. Mean illness duration was 9 months. Subsequently, 21 (72%) developed myoclonus 23 (79%) pyramidal features. Magnetic...
Establishing an early clinical diagnosis in variant Creutzfeldt-Jakob disease (vCJD) can be difficult, resulting extended periods of uncertainty for many families and sometimes a view that patients have been subjected to unnecessary investigations. This issue is accentuated by the progressive nature vCJD difficulty achieving confident before advanced stage illness. Although diagnostic delay may result non-specific features, systematic analysis process was undertaken, with aim trying achieve...
The single fiber needle electrode (SFNE), which is designed to isolate muscle action potentials, has played an important role in the diagnosis of myasthenia gravis (MG). However, concentric (CNE) been recently adopted by some workers study neuromuscular instability MG, and reference data have also obtained healthy subjects. In this we wanted establish whether acquired using SFNE comparable that CNE when studying patients with MG. We established for our laboratory orbicularis oculi (OO)...
We describe a young woman who presented with malignant systemic hypertension and fulminant idiopathic intracranial hypertension. This is rare combination, but both diagnoses should be considered in patients optic disc swelling whom cerebral imaging does not suggest an alternative cause. In this case, was identified treated before the recognised. Visual failure evident at presentation prior to blood pressure manipulation. It likely that combination of conditions increased vulnerability nerve...
Neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are rare disorders often seen in highly specialized services or tertiary centres. We aimed to assess if cohort characteristics depend on the origin of referral catchment areas serviced by our centre (i.e. local, regional national).
Many head and neck surgeons believe that young patients with cancer (HNCA) have poorer outcomes than older patients, whereas the evidence in literature is mixed. We sought to review our HNCA population evaluate for survival differences between patients.Matched pair retrospective cohort study.A matched study was completed of mucosal at academic center (2003-2008). Patients aged 45 or less when diagnosed were identified as cases one-to-one controls by site tumor, stage disease, gender. Risk...
Dacryocystitis is inflammation of the nasolacrimal duct often accompanied by obstruction. It common in rabbits and a challenge to treat. This article discusses anatomy pathophysiology disease suggests possible underlying factors. also clinical presentation, diagnosis, treatment prognosis for affected this condition. Please note: Wiley-Blackwell are not responsible content or functionality any supporting information supplied authors. Any queries (other than missing material) should be...
Community-based neurological data about human T lymphotropic virus type 1 (HTLV-1) morbidity in sub-Saharan Africa are scarce.To ascertain the prevalence of morbidity, particular tropical spastic paraparesis (TSP), among HTLV-1-infected subjects and to compare TSP with that non-infected a rural West African population.A cross-sectional study cases controls (ratio 4:1) from community (population approximately 10 000, HTLV-1 7.7%). One neurologist masked serological status assessed all...