OBJECTIVE The study goal was to validate a disease‐specific health status instrument for use in patients with nasal obstruction. DESIGN, SETTINGS, AND PATIENTS consisted of prospective validation conducted at 4 academic medical centers 32 adults septal deformity. METHODS Prospective occurred 2 stages. Stage 1 the development preliminary (alpha‐version) potential items. test alpha‐version item performance, internal consistency, and test‐retest reliability; construct, discriminant, criterion...

The purpose of this study was to characterize suicide rates among patients with cancer in the United States and identify patient disease characteristics associated higher rates. Prior studies, mostly Europe, have suggested that may be at increased risk for suicide, but large cohort studies comparing general population not been performed States.Patients were residents geographic areas served by Surveillance, Epidemiology, End Results (SEER) program who diagnosed from 1973 2002. Comparisons US...

OBJECTIVE Our goal was to assess disease‐specific quality of life outcomes after nasal septoplasty in adults with obstruction. DESIGN, SETTINGS, AND PATIENTS We conducted a prospective observational multicenter study 14 sites and 16 investigators, including private practice academic settings. Patients had septal deviation symptomatic obstruction for at least 3 months, medical management failed. METHODS completed validated instrument (the Nasal Obstruction Septoplasty Effectiveness (NOSE)...

There are numerous head and neck specific quality of life questionnaires, each having its own merits disadvantages. The University Washington questionnaire has been widely used is notable by the inclusion a shoulder dysfunction domain, domain importance ratings, patient free text. It short, simple to process, provides clinically relevant information. However, it lacked any psychological dimension life. aim this study was report two domains (mood, anxiety) most recent refinement (version 3).A...

OBJECTIVE To determine whether human papillomavirus (HPV) type 16 affects survival in oral squamous cell carcinoma. STUDY DESIGN Two hundred fifty‐four patients diagnosed with primary cancer were studied for relation to tumor HPV status. Kaplan‐Meier analysis and Cox proportional hazard models used assess estimate ratios adjusted potential confounders. RESULTS DNA was detected 15.1% of tumors. positive had significantly reduced all‐cause mortality (hazard ratio [HR] estimates = 0.34, 95% CI...

Abstract Oral squamous cell carcinoma (OSCC) is associated with substantial mortality and morbidity. To identify potential biomarkers for the early detection of invasive OSCC, we compared gene expressions incident primary oral dysplasia, clinically normal tissue from surgical patients without head neck cancer or preneoplastic lesions (controls), using Affymetrix U133 2.0 Plus arrays. We identified 131 differentially expressed probe sets a training set 119 OSCC 35 controls. Forward stepwise...

<h3>Objectives</h3> To summarize our quality-of-life (QOL) research findings for patients with head and neck cancer, to suggest areas future productive QOL research, discuss how undertake studies in a cost-effective manner. <h3>Design</h3> Review of previously published analyses advanced larynx oropharynx neck-dissection cases current data from the complete set patients. <h3>Patients</h3> From January 1, 1993, through December 31, 1998, on 549 were entered database. Of these patients, 364...

<h3>Background</h3> During a 5-year period, we analyzed 3 patient subsets from the University of Washington Quality Life (UW-QOL) Registry and published results. In each instance, editorial review has raised legitimate concerns regarding UW-QOL instrument that deserve public comment. We present our response to these criticisms. Since original publication (1993), have added domains instrument. These additions reflected concern might be missing important elements in spectrum disease-specific...

<h3>Objective</h3> To confirm that high pretreatment uptake of 2-deoxy-2[¹⁸F]fluoro-D-glucose (FDG) detected by positron emission tomography (PET) measured at the primary head and neck squamous cell carcinoma (HNSCC) metastatic nodal disease predicts poor outcomes for HNSCC. <h3>Design Patients</h3> We enrolled 63 consecutive patients with a histological diagnosis HNSCC (including tumors oral cavity, oropharynx, larynx, hypopharynx) from September 2000 through June 2003, into...

Assessment of cochlear implant outcomes centers around speech discrimination. Despite dramatic improvements in perception, music perception remains a challenge for most users. No standardized test exists to quantify clinically practical manner. This study presents the University Washington Clinical Music Perception (CAMP) as reliable and valid English-speaking, adult users.Forty-two subjects were recruited from Medical Center program referred by two manufacturers. Ten normal-hearing...

Objectives Dysphagia-related sequelae are common after head and neck cancer treatment. Our aims were 1) to document overall site-specific dysphagia, stricture, pneumonia rates in a Medicare population, 2) calculate treatment-specific adjusted odds of developing these complications, 3) track changes between 1992 1999. Methods Head patients 1999 identified combined Surveillance Epidemiology End Results (SEER) registry databases. Multivariate analyses determined based on modality. Of 8,002...

To perform a factor analysis using the University of Washington Quality Life Questionnaire version 4 (UW-QOLv4) to establish subscales; report their normative values and variations for patients by age, sex, extent disease, time from treatment; estimate clinical effect sizes potential use in comparative treatment studies.Retrospective cohort.Regional Maxillofacial Unit, Hospital Aintree, Liverpool, England.Patients with primary oral oropharyngeal cancer treated surgery or without adjuvant...

OBJECTIVES To identify risk factors for and the rate of wound complications after laryngectomy in a large, prospectively collected national dataset, to generate predictive model. STUDY DESIGN We used National Surgical Quality Improvement Program (NSQIP) registry created by Department Veterans Affairs (VA) patients undergoing total from 1989 1999 (n = 2063). linked these data inpatient outpatient VA administrative records capture prior radiation. Over 20 preoperative intraoperative were...

Abstract Objectives Uvulopalatopharyngoplasty (UPPP) is the most common surgical treatment for obstructive sleep apnea (OSA). Anatomic and physiologic abnormalities associated with OSA can make perioperative management difficult. Only single‐site case series provide current estimates of incidence complications, a pooled crude serious complication rate 3.5% mortality 0.4%. The primary objective this study was to calculate morbidity in large, multisite cohort UPPP patients. Study Design...

Background: Accurate baseline staging is necessary to appropriately treat head and neck squamous cell carcinoma.[F-18]-fluorodeoxyglucose positron emission tomography (FDG-PET) valuable for locoregional of primary disease.The effectiveness FDG-PET the detection distant metastatic or synchronous disease remains unproven.Objective: To investigate utility extended into abdomen (extended-field FDG-PET) wide-field tumors.Methods: This a prospective institutional study 35 consecutive patients...

To evaluate the long-term quality of life patients treated for head and neck cancer at a single institution in developing country.Cross-sectional analysis consecutive series patients.Tertiary center hospital Brazil.Eligible subjects included between 1974 1999 carcinoma who had minimum disease-free survival 2 years completed Portuguese version University Washington Quality Life (UW-QOL) questionnaire.Descriptive analyses results comparisons scores each UW-QOL domain, stratified by tumor site,...

Background. The University of Washington Quality Life (UW-QOL) questionnaire is an English-language survey instrument used worldwide to assess the quality life patients with head and neck cancer. To be in other cultures, such instruments require careful translation psychometric validation languages. Methods. cultural adaptation were performed following accepted international guidelines. was on a consecutive series at least 1 year disease-free survival after treatment for squamous cell...

Background. 2-deoxy-2[18F]fluoro-d-glucose–positron emission tomography (FDG-PET) imaging can be registered with CT images and potentially improve neck staging sensitivity specificity in patients head squamous cell cancer. The intent of this study was to examine the use FDG-PET/CT guide intensity modulated radiotherapy (IMRT) planning. Methods. Twenty carcinoma oral cavity, oropharynx, larynx, or hypopharynx underwent FDG-PET contrast-enhanced before dissection surgery. Combined were created...

Background: Depression is an important predictor of post therapy quality life (QOL) in head and neck (H&amp;N) cancer patients. In addition, depression rates may vary among cultures. Objective: As part a larger cross cultural study on QOL differences H&amp;N patients, the goal this project was to translate well-validated English language scale into Swahili, then validate Kenyan Methods, Settings Subjects: Part 1 study, we translated Patient Health Questionnaire-9 (PHQ-9) adhering established...

Objective: Cochlear implants (CI) have provided tremendous benefit for speech recognition in quiet patients with severe and profound hearing impairment, but implant users still great difficulty perceiving music. The purpose of this study was to develop a test quantify music perception by CI listeners clinically practical manner that could be standardized administration at any center. Study Design: Prospective convenience sample. Setting: Hearing research center an academic hospital....

<h3>Objective</h3> To study the difference in gene expression between human papillomavirus (HPV)–positive and HPV-negative oral cavity oropharyngeal squamous cell carcinoma (OSCC). <h3>Design</h3> We used Affymetrix U133 plus 2.0 arrays to examine profiles of OSCC normal tissue. The HPV DNA was detected using polymerase chain reaction followed by Roche LINEAR ARRAY Genotyping Test, differentially expressed genes were analyzed their potential biological roles Ingenuity Pathway Analysis...

Abstract Purpose: Cyclooxygenase-2 (COX-2)–specific inhibition suppresses carcinogenesis in preclinical models and is a promising strategy for preventing oral cancer. In this pilot randomized phase II study, we evaluated the efficacy safety of COX-2 inhibitor celecoxib patients with premalignant lesions (OPL). Experimental Design: Patients were randomly assigned to placebo (n = 18), 100 mg twice daily 17), or 200 15) 12 weeks. Six additional received (400 daily) an unblinded extension study....