Tammy Hedderly
A5090889174- Obsessive-Compulsive Spectrum Disorders
- Autism Spectrum Disorder Research
- Psychosomatic Disorders and Their Treatments
- Eating Disorders and Behaviors
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Child Nutrition and Feeding Issues
- Body Image and Dysmorphia Studies
- Acute Ischemic Stroke Management
- Genetics and Neurodevelopmental Disorders
- Blood Coagulation and Thrombosis Mechanisms
- Neurological disorders and treatments
- Child and Adolescent Psychosocial and Emotional Development
- Peripheral Neuropathies and Disorders
- Trace Elements in Health
- Metabolism and Genetic Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Autoimmune Neurological Disorders and Treatments
- Epilepsy research and treatment
- Williams Syndrome Research
- Respiratory and Cough-Related Research
- Neurological Disorders and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Hereditary Neurological Disorders
- Children's Physical and Motor Development
- Neurogenetic and Muscular Disorders Research
Evelina London Children's Healthcare
2016-2025
King's College London
2015-2025
Guy's and St Thomas' NHS Foundation Trust
2014-2024
St Thomas' Hospital
2011-2024
Kings Health Partners
2011-2023
South London and Maudsley NHS Foundation Trust
2022
University College London
2021-2022
University of Calgary
2021-2022
Tel Aviv University
2021-2022
Trinity College Dublin
2022
To report the clinical and investigative features of children with a diagnosis probable autoimmune encephalopathy, both without antibodies to central nervous system antigens.Patients encephalopathy plus one or more neuropsychiatric symptoms, seizures, movement disorder cognitive dysfunction, were identified from 111 paediatric serum samples referred five tertiary neurology centres Oxford for antibody testing in 2007-2010. A blinded review panel 48 patients encephalitis whose are described....
A working group of the European Society for Study Tourette Syndrome (ESSTS) has developed first assessment guidelines (TS). The available literature including national was thoroughly screened and extensively discussed in expert ESSTS members. Detailed clinical tic disorders their comorbidities both children adults are presented. Screening methods that might be helpful necessary specialists' differential diagnosis process suggested order to further analyse cognitive abilities, emotional...
Significance Xeroderma pigmentosum (XP) is a genetic disorder caused by defective repair of DNA damage. Affected patients are mutated in one eight genes and develop skin pigmentation changes, cancers, ocular surface abnormalities, and, some cases, acute sunburn neurodegeneration. The XP proteins involved different steps the Examination 89 patients, largest reported cohort under long-term follow-up, same multidisciplinary team clinicians scientists has revealed unexpected clinical...
Since the beginning of COVID-19 pandemic, our colleagues working at eight different Tourette syndrome (TS) clinics globally have witnessed a parallel pandemic young people aged 12 to 25 years (almost exclusively girls and women) presenting with rapid onset complex motor vocal tic-like behaviors.1 In most cases, these behavioral patterns are consistent functional neurological disorder. There been striking commonalities in phenomenology behaviors observed across centers Canada, United States,...
Highlights•Recurrent de novo variants identify a new high-confidence TD risk gene: CELSR3•Genes involved in cell polarity are more likely to be disrupted by variants•De sequence may carry simplex families, female probands•De CNVs occur 2 3 times often probands than matched controlsSummaryWe previously established the contribution of damaging Tourette disorder (TD) through whole-exome sequencing 511 trios. Here, we an additional 291 trios and analyze combined set 802 We observe...
<h3>Background</h3> Stroke is a major cause of mortality in children. Conditions that mimic stroke also severe morbidity and require prompt diagnosis treatment. We have investigated the time to cohort children with stroke. <h3>Methods</h3> A population-based was prospectively identified south England. Case notes, electronic hospital admission databases radiology records were reviewed. Timing symptom onset, presentation hospital, first neuroimaging, diagnostic neuroimaging presenting clinical...
Tourette syndrome (TS) among young people is associated with psychosocial difficulties and parents play an important role in the management of condition. Clinical guidelines have been developed for treatment TS tics, but little known about how their perceive options or desired outcomes treatment. The aim this study to explore perceptions treatments tics parents. In-depth interviews 42 a mixed-methods, online survey 295 TS. Participant recruitment was conducted through Tourettes Action (TA):...
Objective To investigate the prognosis and co-occurring disorders, including functional neurological symptoms, in adolescents diagnosed with tic-like behaviour (FTLB). Design This was a single-centre tertiary study UK. A structured clinical interview administered to 43 parents or carers of assessed FTLB at their previous outpatient clinic appointment. Data collected included demographic variables, psychiatric neurodevelopmental diagnoses additional symptoms. Setting UK paediatric tics...
Myoclonus dystonia syndrome is a childhood onset hyperkinetic movement disorder characterized by predominant alcohol responsive upper body myoclonus and dystonia. A proportion of cases are due to mutations in the maternally imprinted SGCE gene. Previous studies have suggested that patients with may an increased rate psychiatric disorders. We established cohort determine extent which disorders form part disease phenotype. In all, 89 clinically suspected were recruited from UK Ireland. was...
Background and aim Clinical centres have seen an increase in tic-like movements during the COVID-19 pandemic. A series of children adolescents are described. Methods retrospective chart review 34 consecutive paediatric patients presenting with sudden onset movements, over 6 months. Results 94% were female, average age or 13.7 years. 44% had a previous diagnosis tics, 47% initially presented to emergency department. Comorbid psychiatric neurodevelopmental disorders reported 91% 68% reporting...
Between 2019 and 2022, there was a marked rise in adolescents/young adults seeking urgent help for functional tic-like behaviours (FTLBs). Given the global scale of this phenomenon, we aimed to pool cases from different institutions an international registry better characterize spectrum facilitate future longitudinal observation.An collaborative group 10 tertiary referral centres tic disorders collected retrospective data on FTLB patients who sought specialists' attention between last...
Arterial ischemic stroke (AIS) is an important cause of acquired brain injury in children. Few prospective population-based studies childhood AIS have been completed. We aimed to investigate the outcome 12 months after event a cohort.Children aged 29 days < 16 years with radiologically confirmed occurring over 1-year period residing southern England (population = 5.99 million children) were eligible for inclusion. Outcome was assessed during home visit using Pediatric Stroke Measure (PSOM)....
One important, but underreported, phenomena in Tourette Syndrome (TS) is the occurrence of 'tic attacks'. These episodes have been described at conferences as sudden bouts tics and/or functional tic-like movements, lasting from 15 minutes to several hours. They also by patients on-line TS communities. To date, there are no reports tic attacks literature. The aim this article stimulate discussion and inform clinical practices describing presentation 12 children (mean age 11 years 3 months;...
Abstract Objective We aimed to describe the extent of neurodevelopmental impairments and identify genetic etiologies in a large cohort patients with epilepsy myoclonic atonic seizures (MAE). Methods deeply phenotyped MAE for features, intellectual disability, autism spectrum disorder, attention‐deficit/hyperactivity disorder using standardized neuropsychological instruments. performed exome analysis (whole sequencing) filtered on neuropsychiatric gene sets etiologies. Results analyzed 101...