A5064901701- Genetic Neurodegenerative Diseases
- Obsessive-Compulsive Spectrum Disorders
- Neurological disorders and treatments
- Autism Spectrum Disorder Research
- Parkinson's Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Eating Disorders and Behaviors
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Psychosomatic Disorders and Their Treatments
- Epilepsy research and treatment
- Neurology and Historical Studies
- Mental Health and Psychiatry
- Botulinum Toxin and Related Neurological Disorders
- Schizophrenia research and treatment
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Body Image and Dysmorphia Studies
- Attention Deficit Hyperactivity Disorder
- Health Systems, Economic Evaluations, Quality of Life
- EEG and Brain-Computer Interfaces
- Mental Health Treatment and Access
- Cannabis and Cannabinoid Research
- Mental Health Research Topics
- Psychiatric care and mental health services
University of Birmingham
2015-2024
Huntington's Disease Association
2016-2024
Birmingham and Solihull Mental Health NHS Foundation Trust
2012-2023
Centre for Mental Health
2012-2022
NIHR Surgical Reconstruction and Microbiology Research Centre
2019
Mental Health Foundation
2009-2018
University of Leicester
1996-2016
Leicestershire Partnership NHS Trust
2016
Cardiff University
2016
King's College London
2014
Huntington's disease is an autosomal-dominant neurodegenerative caused by CAG trinucleotide repeat expansion in HTT, resulting a mutant huntingtin protein. IONIS-HTTRx (hereafter, HTTRx) antisense oligonucleotide designed to inhibit HTT messenger RNA and thereby reduce concentrations of huntingtin. We conducted randomized, double-blind, multiple-ascending-dose, phase 1-2a trial involving adults with early disease. Patients were randomly assigned 3:1 ratio receive HTTRx or placebo as bolus...
Effective treatment of epilepsy depends on medication compliance across a lifetime, and studies indicate that drug tolerability is significant limiting factor in maintenance. Available antiepileptic drugs (AEDs) have the potential to exert detrimental effects cognitive function therefore compromise patient wellbeing. On other hand, some agents may serve enhance function. In this review paper, we highlight range cognition linked variety newer older AEDs, encompassing key alterations both...
The majority of Huntington's disease (HD) mutation carriers experience some psychopathology during their lifetime, varying from irritability to psychosis, but prevalences particular symptoms vary widely due diverse study populations in different stages HD and the use assessment methods.The population consisted 1993 15 European countries, all participating observational REGISTRY study. behavioural section Unified Rating Scale was used examine prevalence correlates five neuropsychiatric...
<b>Background:</b> Eighteen patients with severe and refractory Tourette syndrome (TS) underwent bilateral thalamic deep brain stimulation (DBS). <b>Objective:</b> To assess the long-term outcome on tics, behavioral symptoms, cognitive functions in largest case series of DBS for TS to date. <b>Methods:</b> In this prospective cohort study, 15 original 18 were evaluated before after surgery according a standardized protocol that included both neuropsychiatric neuropsychological assessments....
Tourette syndrome (TS) is a chronic neurodevelopmental disorder characterized by tics: repetitive, involuntary movements and vocalizations. These symptoms can have significant impact on patients’ daily functioning across many domains. Tics tend to be most severe in child adolescent sufferers, so their presence has the potential period of life that both critical for learning often associated with experience greater social tension self-consciousness than adulthood. Furthermore, control over...
Abstract Pilot study of nabilone in Huntington's disease (HD). Double‐blind, placebo‐controlled, cross‐over versus placebo. Primary outcome, Unified Disease Rating Scale (UHDRS) total motor score. Secondary measures: UHDRS subsections for chorea, cognition and behavior, neuropsychiatric inventory (NPI). 44 randomized patients received either (1 or 2 mg) followed by placebo (n = 22), 22). Recruiting was straightforward. Nabilone safe well tolerated, no psychotic episodes. Assessment dose...
Mental and neurological conditions are classified in different chapters of diagnostic manuals. <b>P D White</b>, <b>H Rickards</b>, <b>A Z J Zeman</b> argue that this distinction is inconsistent with current scientific understanding the should be grouped together as disorders nervous system
Tourette syndrome (TS) among young people is associated with psychosocial difficulties and parents play an important role in the management of condition. Clinical guidelines have been developed for treatment TS tics, but little known about how their perceive options or desired outcomes treatment. The aim this study to explore perceptions treatments tics parents. In-depth interviews 42 a mixed-methods, online survey 295 TS. Participant recruitment was conducted through Tourettes Action (TA):...
Broome, M. R., & Bortolotti, L. (Eds.). (2009). Psychiatry as Cognitive Neuroscience: Philosophical Perspectives. Oxford, UK: Oxford University Press. Pp. 304. ISBN-13 9780199238033. $65.00 Prior t...
Schachter, S. C., & LaFrance, W. Jr. (Eds.). (2010). Gates and Rowan's non-epileptic seizures (3rd ed.). Cambridge, UK: Cambridge University Press. Pp. 370. ISBN 978 0 521 51763 8. $130.00 Rece...
Previous studies indicate increased prevalences of suicidal ideation, suicide attempts, and completed in Huntington's disease (HD) compared with the general population. This study investigates correlates predictors ideation HD.The cohort consisted 2106 HD mutation carriers, all participating REGISTRY European Disease Network. Of 1937 participants without at baseline, 945 had one or more follow-up measurements. Participants were assessed for by behavioural subscale Unified Rating Scale...
It is estimated that one in five patients referred to specialist epilepsy clinics for refractory seizures have psychogenic nonepileptic (PNES). Despite the high prevalence, little known about prognosis of with PNES. In this paper we set out systematically assess published original studies on and outcome predictors Our literature search across databases Medline, PsycINFO, EMBASE generated 18 meeting criteria. Prognosis was found be poor adults, but good children. Predictors included presence...
This study aimed to evaluate the feasibility and benefit of a structured exercise intervention in people with Huntington's Disease (HD).This was conducted at 6 sites, participants were randomized into either or control (usual care) groups, assessed baseline, 13 26 weeks. The 12 week, three times per week progressive program, including aerobic (stationary cycling) upper lower body strengthening tapered 1:1 support for 20 36 sessions.314 adults eligibility: 248 did not meet inclusion criteria,...