A5037154902- Diabetes Management and Research
- Diabetes and associated disorders
- Global Cancer Incidence and Screening
- Genetic Neurodegenerative Diseases
- COVID-19 Impact on Reproduction
- COVID-19 and healthcare impacts
- Health Policy Implementation Science
- Pregnancy and preeclampsia studies
- Adolescent and Pediatric Healthcare
- Maternal and fetal healthcare
- Chronic Disease Management Strategies
- Health Systems, Economic Evaluations, Quality of Life
- Ethics in Clinical Research
- Cancer survivorship and care
- Maternal Mental Health During Pregnancy and Postpartum
- Health disparities and outcomes
- Mental Health and Patient Involvement
- Down syndrome and intellectual disability research
- Mobile Health and mHealth Applications
- Pancreatic function and diabetes
- Family and Disability Support Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Child and Adolescent Psychosocial and Emotional Development
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Parkinson's Disease Mechanisms and Treatments
Cardiff University
2015-2024
University of Aberdeen
2024
Keele University
2024
Shrewsbury and Telford Hospital NHS Trust
2024
Primary Health Care
2024
University of Oxford
2024
Cardiff and Vale University Health Board
2024
National Health Service Wales
2024
Noah's Ark Children's Hospital for Wales
2024
NHS Grampian
2024
Few large cohort studies have reported data on maternal, fetal, perinatal and neonatal outcomes associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pregnancy. We report the outcome of infected pregnancies from a collaboration formed early during pandemic between investigators two registries, UK Global Pregnancy Neonatal COVID-19 (PAN-COVID) study American Academy Pediatrics (AAP) Section Neonatal-Perinatal Medicine (SONPM) National Perinatal Registry.
<h3>Background</h3> Postpartum haemorrhage (PPH) can be exacerbated by haemostatic failure. We hypothesized that early fibrinogen replacement, guided viscoelastometric testing, reduces blood product usage and bleed size. <h3>Methods</h3> Women with PPH 1000–1500 ml were enrolled. If Fibtem A5 was ≤15 mm bleeding continued, subjects randomized to concentrate or placebo. The primary outcome compared the number of units red cells, plasma, cryoprecipitate platelets transfused. <h3>Results</h3>...
To understand self-reported potential cancer symptom help-seeking behaviours and attitudes during the first 6 months (March-August 2020) of UK COVID-19 pandemic.
To assess perinatal outcomes for pregnancies affected by suspected or confirmed SARS-CoV-2 infection.Prospective, web-based registry. Pregnant women were invited to participate if they had infection between 1st January 2020 and 31st March 2021 the impact of on maternal including miscarriage, stillbirth, fetal growth restriction, pre-term birth transmission infant.Between April 2021, study recruited 8239 participants who SARs-CoV-2 episodes in pregnancy 2021. Maternal death 14/8197 (0.2%)...
Many people with intellectual disabilities find it hard to control their anger and this often leads aggression which can have serious consequences, such as exclusion from mainstream services the need for potentially more expensive emergency placements.To evaluate effectiveness of a cognitive-behavioural therapy (CBT) intervention management in disabilities.A cluster-randomised trial group-based 12-week CBT, took place day was delivered by care staff using treatment manual. Participants were...
This study aimed to evaluate the feasibility and benefit of a structured exercise intervention in people with Huntington's Disease (HD).This was conducted at 6 sites, participants were randomized into either or control (usual care) groups, assessed baseline, 13 26 weeks. The 12 week, three times per week progressive program, including aerobic (stationary cycling) upper lower body strengthening tapered 1:1 support for 20 36 sessions.314 adults eligibility: 248 did not meet inclusion criteria,...
Postpartum haemorrhage (PPH) can be exacerbated by haemostatic failure. Based on data from trauma studies, empirical infusions of fresh frozen plasma (FFP) are often given during severe PPH if coagulation tests unavailable. This study observed a cohort women with moderate/severe in whom FFP infusion was guided the use viscoelastometric point-of-care testing (VE-POCT) and clinical assessment.Women were enrolled into this observational when blood loss measured or suspected to about 1000 mL. If...
Fissure sealant (FS) and fluoride varnish (FV) have been shown to be effective in preventing dental caries when tested against a no-treatment control. However, the relative clinical effectiveness cost-effectiveness of these interventions is unknown. To compare FS FV first permanent molars (FPMs) 6- 7-year-olds determine their acceptability. A randomised controlled allocation-blinded trial with two parallel arms. targeted population programme using mobile clinics (MDCs) schools located areas...
Importance Physicians work long, often unpredictable hours and experience multiple work-related stressors, which may adversely affect their personal relationships. Objective To assess the associations of a couples’ workshop for physicians partners with burnout, self-valuation, impact on relationships (IWPR). Design, Setting, Participants In this cohort study, participants were grouped into an immediate intervention group delayed control group, later compared. The in gathered at resort near...
Background Obesity has significant health and NHS cost implications. Relatively small reductions in weight have clinically important benefits, but long-term loss maintenance (WLM) is challenging. Behaviour change interventions been identified as key for WLM. Motivation crucial to supporting behaviour change, motivational interviewing (MI) a successful approach changing behaviours. The study was designed an adequately powered, pragmatic randomised controlled trial (RCT); however, owing...
Targeted public awareness interventions are needed to improve earlier cancer diagnosis and reduce socioeconomic inequalities in outcomes. The health check (intervention) is a touchscreen questionnaire delivered by trained lay advisors that aims raise of symptoms risk factors encourage timely help seeking.
Purpose Recruitment and follow-up in epidemiological studies are time-consuming expensive. Combining online data collection with a register of individuals who agree to be contacted about research opportunities provides an efficient, cost-effective platform for population-based research. HealthWise Wales (HWW) aims facilitate by recruiting cohort have consented informed projects, advertising participants, supporting on specific topics providing access linked healthcare secondary analyses. In...
Abstract Background People with intellectual disabilities ( ID ) are rarely asked about their experiences as users of psychological services and little is known the views clients who have undergone cognitive behavioural therapy CBT ). This study aimed to gather adults had recently taken part in a cluster randomised control trial RCT staff‐delivered manualised anger management group intervention. Method A qualitative method, Interpretative Phenomenological Analysis IPA ), was employed eleven...
Task-specific training may be a suitable intervention to address mobility limitations in people with Huntington disease (HD).
Postpartum haemorrhage (PPH) is a major cause of maternal morbidity. Bleeding caused by combination physical causes, such as failure the uterus to contract or operations, and made worse impairment blood clotting system. A number studies have shown that low levels factor fibrinogen are associated with progression bleeding, need for invasive interventions transfusions red cells fresh frozen plasma (FFP). This trial will investigate whether early infusion concentrate during PPH, aim correcting...
Worldwide, cancer screening faced significant disruption in 2020 due to the COVID-19 pandemic. If this has led changes public attitudes towards and reduced intention participate, there is a risk of long-term adverse impact on outcomes. In study, we examined previous participation future intentions take part cervical colorectal (CRC) following first national lockdown UK. Overall, 7543 adults were recruited cross-sectional online survey August–September 2020. Logistic regression analyses used...
Following the detection of fetal growth restriction, there is no consensus about criteria that should trigger delivery in late preterm period. The consequences inappropriate early or are potentially important yet practice varies widely around world, with abnormal findings from heart rate monitoring invariably leading to delivery. Indices derived cerebral Doppler examination may guide such decisions although few studies this area. We propose a randomised, controlled trial establish optimum...
Background Cannabis has been associated with poorer mental health, but little is known of the effect synthetic cannabinoids or cannabidiol (often referred to as CBD). Aims To investigate associations cannabis, and health in adolescence. Method We conducted a cross-sectional analysis 13- 14-year-old adolescents across England Wales 2019–2020. Multilevel logistic regression was used examine association lifetime use self-reported symptoms probable depression, anxiety, conduct disorder auditory...
New Start, a structured, validated, multidisciplinary training programme in sentinel lymph node biopsy (SLNB), was established to allow the introduction and rapid transfer of appropriate knowledge technical skills ensure safe competent practice across UK.Multidisciplinary teams attended theory/skills laboratory course, following which they performed 30 consecutive SLNBs, either concurrently with their standard axillary staging procedure (training model A) or as stand-alone SLNB B). according...
Self-management and self-efficacy for physical activity is not routinely considered in neurologic rehabilitation.This study assessed feasibility outcomes of a 14-week self-management coaching intervention compared with social contact Huntington disease (HD) to inform the design future full-scale trial.Assessor blind, multisite, randomized pilot trial.Participants were recruited at baseline, 16 weeks following randomization, then again 26 HD specialist clinics delivery by trained coaches...