A5018862087- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Cardiovascular Issues in Pregnancy
- Maternal and fetal healthcare
- Neonatal and fetal brain pathology
- Body Composition Measurement Techniques
- Neonatal Respiratory Health Research
- Hemodynamic Monitoring and Therapy
- Assisted Reproductive Technology and Twin Pregnancy
- Preterm Birth and Chorioamnionitis
- Pelvic floor disorders treatments
- Prenatal Screening and Diagnostics
- Reproductive System and Pregnancy
- Thyroid Disorders and Treatments
- Cardiovascular Function and Risk Factors
- Pregnancy and Medication Impact
- Cardiovascular Disease and Adiposity
- Anorectal Disease Treatments and Outcomes
- Neuroscience of respiration and sleep
- Maternal and Perinatal Health Interventions
- Renal and Vascular Pathologies
- Cardiovascular Health and Disease Prevention
- Cardiac, Anesthesia and Surgical Outcomes
- Endometriosis Research and Treatment
Policlinico Casilino
2016-2025
University of Rome Tor Vergata
2016-2025
IRCCS Materno Infantile Burlo Garofolo
2023
University of Trieste
2023
KU Leuven
2017
Imperial College London
2017
Fatebenefratelli Hospital
2005-2016
Policlinico S.Orsola-Malpighi
2011
University of Modena and Reggio Emilia
2008
Pathological Society
2000
Because early and late preeclampsia (PE) are thought to be different disease entities, we compared maternal cardiac function at 24 weeks gestation in a group of normotensive asymptomatic patients with subsequent development (<34 gestation) (>or=34 PE (blood pressure >140/90+proteinuria >300 mg/dL) detect possible differences the hemodynamic state. A 1345 nulliparous women underwent uterine artery Doppler evaluation echocardiography calculating total vascular resistance. In follow-up 107...
Objective The Italian Association of Preeclampsia (AIPE) and the Society Perinatal Medicine (SIMP) developed clinical questions on maternal hemodynamics state art. Study Design AIPE SIMP experts were divided in small groups invited to propose an overview existing literature specific topics related proposed, developing, wherever possible, and/or research recommendations based available evidence, expert opinion, importance. Draft with a rationale submitted 8th Consensus Expert Panel for...
Abstract Physiological concentrations of progesterone stimulate the activity endocannabinoid-degrading enzyme anandamide hydrolase (fatty acid amide hydrolase, FAAH) in human lymphocytes. At same concentrations, membrane-impermeant conjugate with BSA was ineffective, suggesting that binding to an intracellular receptor needed for activity. Stimulation FAAH occurred through up-regulation gene expression at transcriptional and translational level, partly mediated by Th2 cytokines. In fact,...
PROBLEM: The aim of this study is to evaluate the role mild thyroid abnormalities in recurrent spontaneous abortion, and assess effects two different therapeutical protocols. METHOD: A prospective population aborters with abnormalities, evaluating obstetric outcome 42 patients. Sixteen autoantibodies positive patients were treated replacement therapy, while 11 received intravenous immunoglobulins (IVIG). Fifteen patients, characterized by negative antithyroid antibodies, having underlying...
We evaluated the predictive value of elevated total vascular resistance on outcome pregnancy in normotensive high-risk primigravidas with bilateral notching uterine artery Doppler. A 526 referred to obstetrics outpatient clinic Tor Vergata University at 20 22 weeks’ gestation were submitted a maternal echocardiographic examination and Doppler evaluation 24 gestation. Blood pressure was recorded time examination, calculated, geometric pattern left ventricle assessed. Patients followed until...
To evaluate pregnancy, delivery and neonatal outcome in singleton primiparous versus multiparous women with/without endometriosis.Multicentric, observational cohort study on a group of Caucasian pregnant (n = 2239) interviewed during their hospitalization for five Italian Gynecologic Obstetric Units (Siena, Rome, Padua, Varese Florence).Primiparous with endometriosis 219) showed significantly higher risk small gestational age fetuses (OR: 2.72, 95% CI 1.46-5.06), diabetes 2.13, 1.32-3.44),...
ABSTRACT Objectives To explore the association between fetal umbilical and middle cerebral artery (MCA) Doppler abnormalities outcome in late preterm pregnancies at risk of growth restriction. Methods This was a prospective cohort study singleton restriction 32 + 0 to 36 6 weeks gestation, enrolled 33 European centers 2017 2018, which MCA velocimetry performed. Pregnancies were considered if they had estimated weight and/or abdominal circumference (AC) < 10 th percentile, abnormal...
Abstract Objective To determine reference values of fetal subcutaneous tissue thickness (SCTT) throughout gestation in a healthy population and to compare them with those from pregnant women gestational diabetes under standard therapy. Methods Three hundred three recruited high‐risk pregnancy clinic were classified as being ( n = 218) or having 85) on the basis negative positive oral glucose tolerance test, respectively. They enrolled into cross‐sectional study at 20 weeks' gestation....
To test the hypothesis of existence a relationship between central and peripheral hemodynamic parameters by longitudinal evaluation maternal echocardiographic uteroplacental resistance modifications during normal pregnancy.Forty-three healthy normotensive primigravidae were evaluated at 12 +/- 1, 21 33 1 weeks gestation with uterine artery color Doppler examinations to identify morphologic, systolic, diastolic variables.Cardiac output stroke volume significantly increased pregnancy. Uterine...
Abstract Objective To assess the differences in fetal body compartments between fetuses with normal growth and those reduced intrauterine growth, during third trimester, through ultrasonographic determination of subcutaneous tissue thickness (SCTT). Methods Twenty‐eight patients were enrolled into this case control study carried out at 30–31 weeks' gestation. Two groups matched for maternal age pregestational mass index: controls ( n = 14) growth‐restricted (IUGR) 14). Routine...
the aims of present study were to compare haemodynamic effects oxytocin and carbetocin assess efficacy these two drugs in terms blood loss additional uterotonic needed caesarean section at high risk primary post-partum haemorrhage.
Abstract The transcription factor p63 mediates distinct cellular responses, primarily regulating epithelial and oocyte biology. In addition to the two amino terminal isoforms, TAp63 ΔNp63, 3’-end of mRNA undergoes tissue-specific alternative splicing that leads several including p63α, p63β p63γ. To investigate in vivo how different isoforms fulfil functions at developmental levels, we developed a mouse model replacing p63α with by deletion exon 13 Trp63 gene. Here, report whereas organs...
PROBLEM: To compare the use of intravenous immunoglobulins (IVIG) with prednisone plus low‐dose aspirin (LDA) in treating pregnant women a history recurrent fetal loss having antiphospholipid antibody (aPL), terms live‐birth rate and maternal perinatal morbidity. METHOD: A prospective, two‐centers trial study included 82 aborters aPL syndrome. Twenty‐nine were treated LDA one center, 53 received IVIG other center. Maternal outcomes pregnancy complications compared between groups. RESULTS:...
Abstract Doppler ultrasound was used to study the main uterine artery flow velocity waveforms in an unselected population of 272 primiparous women at 22 weeks' gestation. The incidences subsequent complications were as follows: gestational hypertension alone, 4.4%; intrauterine fetal growth retardation 4%; and with retardation, 3.6%. waveform considered abnormal when resistance index greater than 0.58. This identified 9.5% ‘at risk’ predicted either above outcomes overall sensitivity 74%...