A5020667924- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Fetal and Pediatric Neurological Disorders
- Infant Development and Preterm Care
- Neuroscience of respiration and sleep
- Congenital Diaphragmatic Hernia Studies
- Blood Coagulation and Thrombosis Mechanisms
- Cerebral Venous Sinus Thrombosis
- Advanced Neuroimaging Techniques and Applications
- Retinopathy of Prematurity Studies
- Cerebrospinal fluid and hydrocephalus
- Advanced MRI Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Neonatal Health and Biochemistry
- COVID-19 Impact on Reproduction
- Congenital Heart Disease Studies
- Pediatric Pain Management Techniques
- Pregnancy and preeclampsia studies
- Cardiac Arrest and Resuscitation
- Neonatal and Maternal Infections
- Birth, Development, and Health
- Assisted Reproductive Technology and Twin Pregnancy
- Optical Imaging and Spectroscopy Techniques
- Atomic and Subatomic Physics Research
- Emergency and Acute Care Studies
Istituto Giannina Gaslini
2016-2025
University of Genoa
2019-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2024
University of Pavia
2024
Clinical Emergency Hospital Bucharest
2024
Policlinico San Matteo Fondazione
1990-2024
Foundation Center
2024
Istituto Superiore di Sanità
2023
University of Arizona
2020
University of North Texas
2020
Moderate hypothermia in neonates with hypoxic-ischaemic encephalopathy might improve survival and neurological outcomes at up to 18 months of age, although complete assessment this age is difficult. To ascertain more precisely the effect therapeutic on neonatal cerebral injury, we assessed lesions MRI scans infants who participated Total Body Hypothermia for Neonatal Encephalopathy (TOBY) trial.In TOBY trial was graded clinically according changes seen amplitude integrated EEG, were randomly...
Hydrops fetalis is an excessive fluid accumulation within the fetal extra vascular compartments and body cavities. Non-immune hydrops (NIHF), due to causes other than Rh alloimmunization, cause in >85% of all affected individuals. Herein we present update our earlier systematic literature review [Bellini et al., 2009] using publications between 2007 2013. We excluded most initial 31,783 papers by strict selection criteria, thus resulting 24 relevant NIHF describing 1,338 individuals with...
Children born prematurely have a high incidence of visual disorders which cannot always be explained by focal retinal or brain lesions. The aim this study was to test the hypothesis that function in preterm infants is related microstructural development white matter optic radiations. We used diffusion tensor imaging (DTI) with probabilistic tractography delineate radiations at term equivalent age and compared fractional anisotropy (FA) contemporaneous evaluation function. Thirty-seven (19...
ObjectiveTo investigate recombinant human insulin-like growth factor 1 complexed with its binding protein (rhIGF-1/rhIGFBP-3) for the prevention of retinopathy prematurity (ROP) and other complications among extremely preterm infants.Study designThis phase 2 trial was conducted from September 2014 to March 2016. Infants born at a gestational age 230/7 weeks 276/7 were randomly allocated rhIGF-1/rhIGFBP-3 (250 µg/kg/ 24 hours, continuous intravenous infusion <24 hours birth postmenstrual...
Background Oxidized heme iron forms methemoglobin (MeHb), impairing the oxygen-binding capability of hemoglobin molecules. Nitric oxide (NO) obtained from glyceryl trinitrate (GTN) patches can cause MeHb formation during limb ischemia topical treatment. This case reports a preterm infant treated with multiple GTN who developed elevated levels, potential therapy complication. Case presentation A female newborn (25 + 4 weeks, 560 g) was delivered by cesarean due to maternal HELLP syndrome and...
It remains unclear whether “sucrose analgesia” is related to a pre- or postabsorptive mechanism. In double blind cross over study sucrose reduced the pain response of preterm infants exposed heel prick blood samples only when it was administered into mouth. ineffective intragastrically.
Objective: To assess diagnostic accuracy of cranial ultrasonography (CUS) in detecting low-grade (i.e. grade I and II) germinal matrix hemorrhage-intraventricular hemorrhage (GMH-IVH) very low birth weight (VLBW) infants.Methods: Among VLBW infants who were admitted to Gaslini Children's Hospital neonatal intensive care unit between January November 2012, patients underwent both serial CUS since magnetic resonance susceptibility-weighted imaging (SWI) at term-equivalent age included this...
Exosomes are secreted nanovesicles that able to transfer RNA and proteins target cells. The emerging role of mesenchymal stem cell (MSC) exosomes as promoters aerobic ATP synthesis restoration in damaged cells, prompted us assess whether they contain an extramitochondrial respiration capacity. were isolated from culture medium human MSCs umbilical cord ≥37-wk-old newborns or between 28- 30-wk-old (i.e., term preterm infants). Characterization samples was conducted by cytofluorometry....
Neuroinflammation has a key role in the pathogenesis of perinatal brain injury. Caffeine, nonspecific antagonist adenosine receptors (ARs), is widely used to treat apnea prematurity and been linked decrease incidence cerebral palsy premature infants. The mechanisms explaining its neuroprotective effect have not yet elucidated. objective this study was characterize expression ARs two neonatal rat models neuroinflammation determine A2aR blockade on microglial activation assessed through...
The COVID-19 pandemic has changed individuals' lifestyles to a great extent, particularly in Italy. Although many concerns about it have been highlighted, its impact on children and adolescents scarcely examined. purpose of this study was explore behavioral consequences coping strategies related the among families Italy, by focusing developmental ages from caregivers' perspective, 3 weeks into quarantine. An exploratory cross-sectional online survey conducted over 14 days. Google Forms...
Objective To evaluate the association between neuroimaging and outcome in infants with congenital cytomegalovirus (cCMV), focusing on qualitative MRI quantitative diffusion-weighted imaging of white matter abnormalities (WMAs). Methods Multicentre retrospective cohort study 160 cCMV (103 symptomatic). A four-grade scoring system was applied to cranial ultrasonography acquired at ≤3 months. WMAs were categorised as multifocal or diffuse. Temporal-pole (TPWMAs) consisted swollen cystic...
The potential of sucrose to reduce the pain response in a group healthy premature infants was investigated. Fifteen 32-34 weeks postmenstrual age were tested blind crossover manner on two separate occasions no more than days apart. Either 1 ml 25% solution or sterile water syringed into baby9s mouth 2 minutes before routine heel lancing. Response painful stimuli measured by duration cry and facial expression (pain score). There significant reduction first cry, percentage time spent crying 5...
A substance commercially described as 9sugar free,9 used a sweetener for paracetamol suspension, was evaluated on measures of neonatal pain. Sixty infants were randomly allocated to receive one four solutions before heel stab blood sampling: sterile water (placebo); 25 or 50% sucrose (weight/volume); and the commercial sweet-tasting solution. There significant reduction in crying time pain score 3 minutes after painful stimulus all groups compared with controls. It is concluded that this...