A5027922127- Neonatal Respiratory Health Research
- COVID-19 Clinical Research Studies
- Neonatal and Maternal Infections
- Infant Development and Preterm Care
- Long-Term Effects of COVID-19
- Infant Nutrition and Health
- Respiratory Support and Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Intensive Care Unit Cognitive Disorders
- Clinical Nutrition and Gastroenterology
- Antibiotics Pharmacokinetics and Efficacy
- Hearing, Cochlea, Tinnitus, Genetics
- Neonatal and fetal brain pathology
- Neonatal Health and Biochemistry
- Congenital Diaphragmatic Hernia Studies
- Child and Adolescent Health
- Ear Surgery and Otitis Media
- Child Nutrition and Water Access
- Retinopathy of Prematurity Studies
- Thermal Regulation in Medicine
- Preterm Birth and Chorioamnionitis
- Vitamin K Research Studies
- SARS-CoV-2 detection and testing
- Hemodynamic Monitoring and Therapy
- Pneumonia and Respiratory Infections
Manchester University NHS Foundation Trust
2018-2024
University of Manchester
2017-2024
St Mary's Hospital
2017-2024
St Mary's Hospital
2014-2022
St. Mary's Hospital
2018-2022
Manchester Academic Health Science Centre
2017-2018
University of Liverpool
2011-2012
Liverpool Women's Hospital
2011-2012
Addenbrooke's Hospital
2010
ObjectiveTo investigate recombinant human insulin-like growth factor 1 complexed with its binding protein (rhIGF-1/rhIGFBP-3) for the prevention of retinopathy prematurity (ROP) and other complications among extremely preterm infants.Study designThis phase 2 trial was conducted from September 2014 to March 2016. Infants born at a gestational age 230/7 weeks 276/7 were randomly allocated rhIGF-1/rhIGFBP-3 (250 µg/kg/ 24 hours, continuous intravenous infusion <24 hours birth postmenstrual...
Aminoglycosides are commonly prescribed antibiotics used for the treatment of neonatal sepsis. The MT-RNR1 m.1555A>G variant predisposes to profound aminoglycoside-induced ototoxicity (AIO). Current genotyping approaches take several days, which is unfeasible in acute settings. To develop a rapid point-of-care test (POCT) before implementation this technology setting guide antibiotic prescribing and avoid AIO. This pragmatic prospective trial recruited neonates admitted 2 large intensive...
The British Association of Perinatal Medicine (BAPM) released their revised framework for extremely preterm infant management in 2019. This promotes consideration perinatal optimisation and survival-focused care from 22 weeks gestation onwards. was a departure the previous BAPM which recommended comfort as only infants <23 + 0 weeks.
Advances in neonatal care have resulted improved survival rates for periviable infants (22 + 0-23 6 weeks) with increasing numbers being admitted to intensive units across the United Kingdom. Qualitative research evidences conflict perinatal professionals experience traversing line between providing life-sustaining treatment these infants, whilst not wanting inflict a prolonged period of suffering who will ultimately die. Professionals currently lack adequate prognostic tools accurately...
Background : Impaired early protein intake in very preterm infants contributes to growth failure and may affect long‐term neurocognitive development. The authors have previously shown that a standardized concentrated neonatal parenteral nutrition (scNPN) formulation can improve the efficiency of administration. They recognized could be improved further by modifying original scNPN regimen starting PN within 4 hours. Aim To demonstrate new <29 weeks’ gestation without causing clinically...
There is near-global consensus that all newborns be given parenteral vitamin K1 (VK1 ) at birth as prophylaxis against VK deficiency bleeding (VKDB). Breastmilk has a low content and cases of late VKDB are reported in exclusively breastmilk-fed preterm infants despite birth.To assess the prevalence functional insufficiency based on elevated under-γ-carboxylated (Glu) species Gla proteins, factor II (PIVKA-II), osteocalcin (GluOC), synthesized by liver bone, respectively.Prospective,...
Introduction In conjunction with a beta-lactam, aminoglycosides are the first-choice antibiotic for empirical treatment of sepsis in neonatal period. The m.1555A>G variant predisposes to ototoxicity after aminoglycoside administration and has prevalence 1 500. Current genetic testing can take over 24 hours, an unacceptable delay acute setting. This prospective-observational trial will implement rapid point care test (POCT), facilitating tailored prescribing avoid hearing loss. Methods...
Abstract Aim To explore the views of neonatal intensive care nursing staff on deliverability a novel genetic point‐of‐care test detecting variant associated with antibiotic‐induced ototoxicity. Design An interpretive, descriptive, qualitative interview study. Methods Data were collected using semi‐structured interviews undertaken between January and November 2020. Participants taking part in Pharmacogenetics to Avoid Loss Hearing trial. Results Thematic analysis resulted four themes:...
Background The SurePulse vital signs (VS) device is an innovative wireless heart rate monitor designed for neonatal patients. This study evaluates the application of VS technology in clinical practice. Methods Data were collected about quantitative metrics itself when deployed on real infants and qualitative feedback from perinatal professionals parents regarding their experiences using this novel technology. Results recruited 101 achieved target completion rates healthcare professional...
IGF-I plays a key role in fetal growth and development [1]. exerts pleiotropic effects including cell proliferation, survival differentiation, but also influencing metabolism angiogenesis.
<h3>Background</h3> A recent UK national audit revealed large variations in parenteral nutrition (PN) administration a subgroup of neonatal patients1. The factors involved included timeliness, nutritional adequacy and metabolic complications. It was not clear how much this variation due to differences PN policy or whether very preterm infants (the most dependent) were more at risk. <h3>Aim</h3> To estimate macronutrient intakes resulting from local implementation all level 3 services....
<h3>Background</h3> Pulse oximetry is widely used for monitoring oxygen saturation, but uncertainty remains as to most appropriate target range in preterm babies. Studies have been conducted and various limits put forward. BOOST II trial compared outcomes infants < 28 weeks after randomisation SpO<sub>2</sub> targeting of 85–89% vs 91–95%. In interim analysis the high group had increased 36 week survival low group. <h3>Aim</h3> To find out how much saturation policies vary amongst NICUs...
<h3>Objectives</h3> Birth in the periviable period (22–24+6 weeks) is fraught with ethical, emotional and practical complexities. Professional frameworks advocate for a shared decision- making approach parents about whether instigation of active, survival-focused care appropriate individual infant. Discussion survival neurodevelopmental outcomes encouraged, but only vague descriptors topics to include. Our survey focused on parent-reported, functional children parent experience pre-birth...
National Institute for Clinical Excellence (NICE) guidance the management of neonatal sepsis recommends a first-line antibiotic regimen containing an aminoglycoside (gentamicin). Aminoglycoside exposure causes sensorineural hearing loss in individuals with specific mitochondrial genetic variant (m.1555A>G). This can be detected promptly (in <30 min) by point care test. NICE does allow variation regimes depending on local microbiology guidance. As practices vary, this survey aimed to...
Adequate folate intake is required in preterm infants for rapid growth and development, but there little evidence to back recommendations. We aimed assess status at discharge early infancy, according exposure sources, particularly those exclusively/predominantly breastfed.
<h3>Aims</h3> Conventional teaching in neonatology is that open cranial sutures protect newborns from brain herniation secondary to raised intracranial pressure. This case series aims disseminate observations a tertiary neonatal centre of following hypoxic-ischaemic injury. <h3>Methods</h3> A retrospective review notes patients admitted the intensive care unit who were found have on MRI scan was performed using Badger. Their clinical history and imaging reports recorded. literature search...
Abstract Aim To determine agreement between neonatal capillary blood gases taken with plastic and glass tubes. Methods An study was carried out in a regional tertiary unit. Inpatient babies ≥1 kg were recruited to the when parents gave consent. After taking routine tube sample, sample run if heel continued bleed. Successful pairs recorded analysed against pre‐defined acceptable differences. Assessment also made of differences failure rates types for each parameter. Results Twenty‐eight...
Ocular infection with HSV causes a chronic T cell–mediated inflammatory lesion in the cornea. Lesion severity is affected by balance of different CD4 cell subsets, greater occurring when activity regulatory cells (Tregs) compromised. In this study, fate-mapping mice were used to assess stability Treg function ocular lesions. We show that once Foxp3<sup>+</sup> functional Tregs may lose Foxp3 and become Th1 could contribute expression. The instability primarily occurred IL-2R<sup>lo</sup> was...
<h3>Introduction</h3> A standardised, concentrated neonatal parenteral nutrition (scNPN1) regimen can increase very preterm protein intake.1 Our aim was to compare macronutrient intake and metabolic tolerance using a modified (scNPN2) designed introduce within 4 h of birth. <h3>Methods</h3> Local audit committee approval obtained. 14-day fluid/drug infusion biochemical data for infants <29 weeks were collected from NICU electronic patient management systems the previous methodology. This...