A5049843856- Toxic Organic Pollutants Impact
- Infant Development and Preterm Care
- Neonatal Respiratory Health Research
- Air Quality and Health Impacts
- Effects and risks of endocrine disrupting chemicals
- Neonatal and fetal brain pathology
- Birth, Development, and Health
- Congenital Heart Disease Studies
- Child Nutrition and Feeding Issues
- Anesthesia and Neurotoxicity Research
- Language Development and Disorders
- Per- and polyfluoroalkyl substances research
- Attention Deficit Hyperactivity Disorder
- Health, Environment, Cognitive Aging
- Carcinogens and Genotoxicity Assessment
- Pregnancy and preeclampsia studies
- Lysosomal Storage Disorders Research
- Hearing Loss and Rehabilitation
- Pediatric Pain Management Techniques
- Mercury impact and mitigation studies
- Infant Nutrition and Health
- Obesity, Physical Activity, Diet
- Family and Disability Support Research
- Environmental Justice and Health Disparities
- Children's Physical and Motor Development
Erasmus MC - Sophia Children’s Hospital
2005-2021
Erasmus MC
2010-2021
University of Groningen
1999-2017
University Medical Center Groningen
2017
Boston Children's Hospital
1986-2014
KU Leuven
2012
Erasmus University Rotterdam
1993-2009
Children's National
2003
George Washington University
2003
Washington University Medical Center
2003
Prenatal exposure to polychlorinated biphenyls (PCBs) and dioxins is associated with changes in the T-cell lymphocyte population healthy Dutch infants. We investigated whether these persist into later childhood background PCBs prevalence of infectious or allergic diseases humoral immunity at preschool age. The total study group consisted 207 mother-infant pairs. estimated prenatal by sum 118, 138, 153, 180 (sigmaPCB) maternal cord plasma breast-fed infants dioxin, planar, mono-ortho PCB...
Objective. Recent reports warn that the worldwide cell culture capacity is insufficient to fulfill increasing demand for human protein drugs. Production in milk of transgenic animals an attractive alternative. Kilogram quantities product per year can be obtained at relatively low costs, even small such as rabbits. We tested long-term safety and efficacy recombinant α-glucosidase (rhAGLU) from rabbit treatment lysosomal storage disorder Pompe disease. The disease occurs with estimated...
To evaluate the effects of in utero and lactational exposure to polychlorinated biphenyls (PCBs) dioxins on mental psychomotor development infants.Prenatal PCB was estimated from levels maternal plasma during last month pregnancy. Postnatal dioxin breastfed infants calculated human milk samples duration breastfeeding. Infants were examined at 3, 7, 18 months age with Bayley Scales Infant Development.General community.Voluntary sample 207 mother-infant pairs. One hundred five 102...
Polychlorinated biphenyls (PCBs) are persistent pollutants that ubiquitous in the food chain, and detectable amounts blood of almost every person most populations have been examined. Extensive evidence from animal studies shows PCBs neurotoxins, even at low doses. Interpretation human data regarding low-level, early-life PCB exposure subsequent neurodevelopment is problematic because levels were not similarly quantified across studies. We expressed 10 a uniform manner using combination...
Food is the major source for polychlorinated biphenyl (PCB) and dioxin accumulation in human body. Therefore, investigating food habits from early ages until reproductive age (25 years) important order to assess exposure risk next generation. The objective of this study was PCB/dioxin relative contribution different foods total during preschool age. Particularly, importance lactational vs. dietary adulthood investigated. A cohort 207 children studied birth Based on 3 planar PCBs 17...
We examined whether very preterm (< or =30 weeks gestation) children at early school age have impairments in executive function (EF) independent of IQ and processing speed, demographic neonatal risk factors were associated with EF impairments. A consecutive sample 50 (27 boys 23 girls) born (mean = 5.9 years, SD 0.4, mean gestational 28.0 weeks, 1.4) was compared to a age-matched full-term controls (23 girls 27 boys, 6.0 0.6) respect performance on comprehensive battery, assessing the...
Newborns on ventilatory support often receive morphine to induce analgesia. Animal experiments suggest that this may impair subsequent cognitive and behavioral development. There are sparse human data long-term effects of neonatal morphine. We aimed investigate the continuous administered in period child’s functioning. conducted a follow-up study among 5-year-olds who, as mechanically ventilated neonates, had participated placebo-controlled trial administration pain neurologic outcome. They...
Young adults who were born very preterm or with a low birth weight remain at risk for physical and neurodevelopmental problems lower academic achievement scores. Data, however, are scarce, hospital based, mostly done in small populations, need additional confirmation.Infants < 32 weeks of gestation and/or 1500 g The Netherlands 1983 (Project on Preterm Small Gestational Age Infants) reexamined age 19. Outcomes adjusted nonrespondents using multiple imputation categorized into none, mild,...
To examine executive functioning in very preterm (gestational age ≤30 wks) children at 4 to 12 years of age.Two-hundred (106 males, 94 females; mean gestational 28.1wks, SD 1.4; 8y 2mo, 2y 6mo) and 230 term 124 39.9wks, 1.2; 4mo, 3mo) without severe disabilities, born between 1996 2004, were assessed on an function battery comprising response inhibition, interference control, switching, verbal fluency, spatial working memory, planning. Multiple regression analyses examined group differences...
Summary Neonatal morphine infusion of 10 μg/kg/h does not affect general functioning 8 to 9 years later and may even have a positive effect on executive function skills. Morphine is widely used treat severe pain in neonatal intensive care unit patients. Animal studies suggest adverse long-term side effects morphine, but follow-up study 5-year-old children who participated morphine-placebo controlled trial as newborns found no such the child’s functioning. This indicated that negatively...
BackgroundInfant exposure to persistent organic pollutants (POPs) may contribute obesity. However, many studies so far have been small, focused on transplacental exposure, used an inappropriate measure assess postnatal through breastfeeding if any, or did not discern between prenatal and effects.ObjectivesWe investigated POPs infant growth (a predictor of obesity).MethodsWe pooled data from seven European birth cohorts with biomarker concentrations polychlorinated biphenyl 153 (PCB-153) (n =...
Objective of this study was to examine the impact executive function (EF) on mathematical and attention problems in very preterm (gestational age ≤ 30 weeks) children. Participants were 200 (mean 8.2 ± 2.5 years) 230 term children 8.3 2.3 without severe disabilities, born between 1996 2004. EFs assessed included verbal fluency, working memory, visuospatial span, planning, impulse control. Mathematics with Dutch Pupil Monitoring System parents teachers rated using standardized behavior...
Polychlorinated biphenyls (PCBs) and dioxins are known as neurotoxic compounds that may modulate sex steroid hormones. Steroid hormones play a mediating role in brain development influence behaviors show differences, such childhood behavior. In this study we evaluated the effects of perinatal exposure to environmental levels PCBs on behavior whether showed differences. As part follow-up Dutch PCB/dioxin at school age, used Pre-School Activity Inventory (PSAI) assess Rotterdam cohort (n =...
To investigate the effects of biological and social factors on cognitive development very low birth weight children, a longitudinal follow-up study was conducted from to 3.6 years age.The group consisted cohort 79 surviving high-risk, infants. Neonatal cerebral ultrasonographic findings neurological score were used as indicators risk. A sociodemographic risk Home Observation for Measurement Environment inventory Cognitive assessed at ages 1 2 by Mental scale Bayley Scales Infant Development...
We report serial magnetic resonance (MR) and sonographic behavior of globus pallidus in 5 preterm 3 term infants with kernicterus describe the clinical context very low birth weight infants. On basis this information, we suggest means diagnosis prevention.Charts MR ultrasound images suspected bilirubin-associated brain damage were reviewed. Included severe hearing loss, quadriplegic hypertonia, abnormal hypersignal on T2-weighted imaging (MRI). In 1 infant who died day 150, was confirmed...