A5016982472- Biosimilars and Bioanalytical Methods
- Pharmaceutical Economics and Policy
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical studies and practices
- Virus-based gene therapy research
- Antibiotics Pharmacokinetics and Efficacy
- Renal and related cancers
- Pharmaceutical Practices and Patient Outcomes
- Renal Transplantation Outcomes and Treatments
- Pharmacogenetics and Drug Metabolism
- Pregnancy and preeclampsia studies
- CAR-T cell therapy research
- Parvovirus B19 Infection Studies
- Antibiotic Resistance in Bacteria
- Cancer Research and Treatments
- Lysosomal Storage Disorders Research
- Energy Harvesting in Wireless Networks
- Biomedical Ethics and Regulation
- Blood Pressure and Hypertension Studies
- Pharmacological Effects and Toxicity Studies
- Drug Transport and Resistance Mechanisms
- Pharmacological Effects of Natural Compounds
- Birth, Development, and Health
- Glycogen Storage Diseases and Myoclonus
- Healthcare cost, quality, practices
KU Leuven
2019-2025
Erasmus MC
2016-2025
Erasmus University Rotterdam
2012-2024
Erasmus MC - Sophia Children’s Hospital
2001-2020
Maasstad Ziekenhuis
2019
Canadian Respiratory Research Network
2016
Vifor Pharma (Switzerland)
2013
American Pharmacists Association
2010
Rotterdam University of Applied Sciences
1999-2009
Eindhoven Cancer Registry
2009
Many computerized physician order entry (CPOE) systems have integrated drug safety alerts. The authors reviewed the literature on response to alerts and interpreted results using Reason's framework of accident causation. In total, 17 papers met inclusion criteria. Drug are overridden by clinicians in 49% 96% cases. Alert overriding may often be justified adverse events due not always preventable. A distinction between appropriate useful should made. alerting system contain error-producing...
Autologous T cells genetically modified to express a chimeric antibody receptor (CAR) against carboxy-anhydrase-IX (CAIX) were administered 12 patients with CAIX-expressing metastatic renal cell carcinoma (RCC). Patients treated in three cohorts maximum of 10 infusions total 0.2 2.1 × 109 CAR cells. CTC grade 2–4 liver enzyme disturbances occurred at the lowest doses, necessitating cessation treatment four out eight 1 and 2. Examination biopsies revealed CAIX expression on bile duct...
Background Across European countries, differences exist in biosimilar policies, leading to variations uptake of biosimilars and divergences savings all over Europe. Objectives The aim this article is provide an overview different initiatives policies that may influence the countries. Recommendations will be formulated on how create sustainable uptake. Methods An was obtained via a questionnaire, supplemented with relevant articles. Topics were organized five themes: availability, pricing,...
Objective. Recent reports warn that the worldwide cell culture capacity is insufficient to fulfill increasing demand for human protein drugs. Production in milk of transgenic animals an attractive alternative. Kilogram quantities product per year can be obtained at relatively low costs, even small such as rabbits. We tested long-term safety and efficacy recombinant α-glucosidase (rhAGLU) from rabbit treatment lysosomal storage disorder Pompe disease. The disease occurs with estimated...
Invasive pulmonary aspergillosis (IPA) is a significant problem in patients with chemotherapy-induced prolonged neutropenia. Because deposition of conidia the first step developing IPA, we hypothesized that inhalation liposomal amphotericin B would prevent IPA.We performed randomized, placebo-controlled trial hematologic disease expected neutropenia for >or=10 days. Patients were randomized to receive or placebo twice week, using an adaptive aerosol delivery system, until neutrophil counts...
Abstract Pompe's disease is an autosomal recessive myopathy. The characteristic lysosomal storage of glycogen caused by acid α‐glucosidase deficiency. Patients with late‐onset present progressive muscle weakness also affecting pulmonary function. In search a treatment, we investigated the feasibility enzyme replacement therapy recombinant human from rabbit milk. Three patients (aged 11, 16, and 32 years) were enrolled in study. They all wheelchair‐bound two them ventilator dependent history...
To study the effects of addition spironolactone to angiotensin-converting enzyme (ACE) inhibition or angiotensin II (AngII) receptor antagonism on proteinuria, blood pressure (BP) and renal function in overt type 2 diabetic nephropathy.A placebo-controlled, double-blind, parallel-group trial patients from two outpatient clinics with a follow-up 1 year.Type macroalbuminuria, despite long-term use an ACE inhibitor AngII blocker were allocated spironolactone, 25-50 mg once daily (n = 29)...
Objectives: This study sought to identify opportunities safely turn off frequently overridden drug–drug interaction alerts (DDIs) in computerized physician order entry (CPOE).
Several beta-blockers are metabolized by the polymorphic enzyme cytochrome P450 2D6 (CYP2D6). CYP2D6*4 is main polymorphism leading to decreased activity. The clinical significance of impaired elimination controversial, and most studies suffer from inclusion small numbers poor metabolizers (PMs) CYP2D6. In this study, association between blood pressure or heart rate was examined in 1,533 users Rotterdam Study, a population-based cohort study. CYP2D6 *4/*4 PMs, adjusted metoprolol 8.5...
Immunocompromised individuals tend to suffer from influenza longer with more serious complications than otherwise healthy patients. Little is known about the impact of prolonged infection and efficacy antiviral therapy in these Among all 189 A virus infected immunocompromised patients admitted ErasmusMC, 71 were hospitalized, since start 2009 H1N1 pandemic. We identified 11 (15%) cases pandemic replication (longer 14 days), despite therapy. In 5 out (45%) oseltamivir resistant H275Y viruses...
Background: Biopharmaceutical medicines represent a growing share of the global pharmaceutical market, and with many these biopharmaceutical products facing loss exclusivity rights, also biosimilars may now enter market. Objectives: This study aims to identify document which investment development strategies are adopted by industrial players in Methods: A descriptive analysis was undertaken top 25 companies according 2015 worldwide prescription drug sales. Strategies were documented...
The nocebo effect is defined as the incitement or worsening of symptoms induced by any negative attitude from non-pharmacological therapeutic intervention, sham, active therapies. When a patient anticipates associated with an medication change in medication, they may then experience either increase this it de novo. Although less known about compared placebo effect, widespread interest observed statin therapy and literature review highlighting across at least ten different disease areas...
Abstract Purpose: Testing safety of Delta24-RGD (DNX-2401), an oncolytic adenovirus, locally delivered by convection enhanced delivery (CED) in tumor and surrounding brain patients with recurrent glioblastoma. Patients Methods: Dose-escalation phase I study 3+3 cohorts, dosing 107 to 1 × 1011 viral particles (vp) 20 patients. Besides clinical parameters, adverse events, radiologic findings, blood, cerebrospinal fluid (CSF), interstitial fluid, excreta were sampled over time analyzed for...
Background: From October 2018, adalimumab biosimilars could enter the European market. However, in some countries, such as Netherlands, high discounts reported for originator product may have influenced biosimilar entry. Objectives: The aim of this paper is to provide a overview (list) prices adalimumab, before and after loss exclusivity; report changes reimbursement status products; discuss relevant policy measures. Methods: Experts countries received survey consisting three parts: 1)...
Abstract Background : In Japan, glycyrrhizin therapy is widely used for chronic hepatitis C and reportedly reduces the progression of liver disease to hepatocellular carcinoma. The aims this study were evaluate effect on serum alanine aminotransferase (ALT), virus (HCV)‐RNA its safety in European patients. Methods Fifty‐seven patients with C, non‐responders or unlikely respond (genotype 1/cirrhosis) interferon therapy, randomized one four dose groups: 240, 160 80 mg placebo (0 glycyrrhizin)....
Background. The treatment of pediatric patients with drugs in hospitals is being impeded by a shortage the availability licensed an appropriate formulation. We have studied extent use that are not for children (unlicensed) and used outside terms product license (off-label). conducted this study Dutch academic children's hospital. Methods. In prospective 5 weeks' duration, we reviewed drug prescriptions ward 3 intensive care units. classified prescribed main categories—licensed, unlicensed,...
OBJECTIVE: In Japan, ALT normalization induced by long-term i.v. glycyrrhizin treatment reportedly reduces the progression of liver disease to hepatocellular carcinoma in chronic hepatitis C patients. The aim this study was evaluate short-term (4-wk) feasibility and efficacy on serum three or six times per week therapy European METHODS: Patients with C, nonresponders, unlikely respond (genotype 1/cirrhosis) interferon were included study. Medication administered for 4 wk; follow-up also...