A5068593117- Pharmaceutical studies and practices
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Antibiotics Pharmacokinetics and Efficacy
- Cardiac Arrest and Resuscitation
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Pediatric Pain Management Techniques
- Pneumonia and Respiratory Infections
- Mechanical Circulatory Support Devices
- Neonatal Respiratory Health Research
- Family and Patient Care in Intensive Care Units
- Inhalation and Respiratory Drug Delivery
- Emergency and Acute Care Studies
- Medical Education and Admissions
- Anesthesia and Neurotoxicity Research
- Pharmacological Effects and Toxicity Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Childhood Cancer Survivors' Quality of Life
- Healthcare professionals’ stress and burnout
- Infant Development and Preterm Care
- Innovations in Medical Education
- Respiratory viral infections research
- Antimicrobial Resistance in Staphylococcus
- Heart Failure Treatment and Management
Erasmus MC - Sophia Children’s Hospital
2016-2025
Erasmus MC
2012-2024
Intensive Care Society
2021
Erasmus University Rotterdam
2002-2020
Boston Children's Hospital
2001-2013
Cambridge University Press
2011
New York University Press
2011
Pediatric Oncology Group
2005
Children's National
2003
George Washington University
2003
Objectives: The original COMFORT scale, including both observational and physiologic items, has been validated for measuring distress in children admitted to a pediatric intensive care unit. However, variables are influenced by drugs given the unit setting. objectives of this study were assess usefulness judgment sedation determine new cutoff points "behavioral" scale (COMFORT-B), using only items. Design: Prospective study. Setting: Pediatric university hospital Patients: Seventy-eight...
Various in vitro, animal, and limited human adult studies suggest a profound inhibitory effect of inflammation disease on cytochrome P-450 3A (CYP3A)-mediated drug metabolism. Studies showing this relationship critically ill patients are lacking, whereas clearance many CYP3A substrates may be decreased, potentially leading to toxicity.To prospectively study the between inflammation, organ failure, midazolam as validated marker CYP3A-mediated metabolism children.From 83 children (median age,...
Background. The treatment of pediatric patients with drugs in hospitals is being impeded by a shortage the availability licensed an appropriate formulation. We have studied extent use that are not for children (unlicensed) and used outside terms product license (off-label). conducted this study Dutch academic children's hospital. Methods. In prospective 5 weeks' duration, we reviewed drug prescriptions ward 3 intensive care units. classified prescribed main categories—licensed, unlicensed,...
To establish frequencies of benzodiazepine and opioid withdrawal symptoms, correlations with total doses duration administration.A prospective, repeated-measures design.Two pediatric intensive care units in a university children's hospital.Seventy-nine children, aged 0 days to 16 yrs, who received intravenous midazolam and/or opioids for >5 days.None.Pediatric unit nurses assessed symptoms using the Sophia Benzodiazepine Opioid Withdrawal Checklist, which includes all (n = 24) described...
To get insight in the endocrine and metabolic responses children with meningococcal sepsis 26 were studied first 48 h after admission. On admission there was a significant difference cortisol/ACTH levels between nonsurvivors (n = 8) survivors 18). Nonsurvivors showed an inadequate cortisol stress response combination to very high ACTH levels, whereas normal significantly higher (0.62 vs. 0.89 μmol/L) moderately increased (1234 231 ng/L). Furthermore, regarding pediatric risk of mortality...
Objective To determine the pharmacokinetics and metabolism of midazolam in pediatric intensive care patients. Design Prospective population pharmacokinetic study. Setting Pediatric unit. Patients Twenty-one patients aged between 2 days 17 yrs. Interventions The metabolites were determined during after a continuous infusion (0.05–0.4 mg/kg/hr) for 3.8 hrs to 25 administered conscious sedation. Measurements Main Results Blood samples taken at different times determination midazolam,...
To construct a reliable and clinically practical instrument for monitoring opioids benzodiazepine withdrawal symptoms in pediatric ICU patients.Instrument development.Intensive care unit an academic children's hospital.79 patients up to age 16 years on intravenous midazolam and/or > or =5 days. An expert panel of 85 physicians nurses rated clinical relevance symptoms.During drug weaning repeated observations were performed with checklist 24 described the literature.For 76 children, 932...
The Sophia Observation withdrawal Symptoms scale is an instrument for screening benzodiazepine and opioid syndrome in pediatric critical care patients. objectives of this study were to establish cutoff scores test sensitivity change. Second, risk factors explored.Prospective observational with repeated measures.Level IV ICU at a university children's hospital.A total 154 children median age 5 months (interquartile range, 0-42 mo) who received continuous infusion benzodiazepines and/or...
<h3>Objective:</h3> To determine whether recognition of Guillain-Barré syndrome (GBS) is delayed in preschool children, what causes this delay, and if the clinical presentation differs from older children. <h3>Methods:</h3> In a retrospective cohort study, standardized data all children with GBS seen at Erasmus MC Sophia Children9s University Hospital Rotterdam 1987 to 2009 were collected regarding presentation, patient9s initial diagnosis, doctor9s delay diagnosis. We compared (<6 years...
Uncertainty exists regarding the optimal dosing regimen for vancomycin in different patient populations, leading to a plethora of subgroup-specific pharmacokinetic models and derived regimens. We aimed investigate whether single model could be developed based on broad dataset covering extremes characteristics. Furthermore, as benchmark current recommendations, we evaluated optimised expected exposure throughout life specific subgroups.A pooled population-pharmacokinetic was built NONMEM data...
To compare daily sedation interruption plus protocolized (DSI + PS) to only (PS) in critically ill children.In this multicenter randomized controlled trial three pediatric intensive care units the Netherlands, mechanically ventilated children with need for sedative drugs were included. They randomly assigned either DSI PS or only. Children both study arms received adjusted on basis of validated scores. Provided a safety screen was passed, group blinded infusions saline; previous...
A drug is granted a license for use after thorough assessment of risks and benefits based on high-quality scientific proof its efficacy safety. Many drugs that are relevant to children not licensed in this population implying the pediatric has been made at all, negative risk-benefit balance children, or insufficient information establish balance. Use without positive exposes potential lack efficacy, unknown toxicity, harm. To aid guideline committees individual prescribers, we here present...
To investigate neurocognitive, psychosocial, and quality of life (QoL) outcomes in children with Multisystem Inflammatory Syndrome Children (MIS-C) seen 3-6 months after PICU admission.National prospective cohort study March 2020 to November 2021.Seven PICUs the Netherlands.Children MIS-C (0-17 yr) admitted a PICU.None.Children and/or parents were median (interquartile range [IQR] 4 mo [3-5 mo]) admission. Testing included assessment QoL reference Dutch pre-COVID-19 general population norms....
Children with syndromal craniofacial synostosis have a high risk for obstructive sleep apnea syndrome. Early diagnosis and treatment can relieve symptoms morbidity. Little is known about the development natural history of syndrome through life. The aim this study was to investigate our experience clinical modalities concerning from birth until current age in children synostosis. one three synostoses (Apert, Crouzon, or Pfeiffer) born between 1984 2001 were evaluated. medical assessed by...