A5082873219- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Respiratory viral infections research
- Sepsis Diagnosis and Treatment
- Congenital Diaphragmatic Hernia Studies
- Pneumonia and Respiratory Infections
- Intensive Care Unit Cognitive Disorders
- Tracheal and airway disorders
- Childhood Cancer Survivors' Quality of Life
- Emergency and Acute Care Studies
- Family and Patient Care in Intensive Care Units
- Infant Development and Preterm Care
- Cardiac Arrest and Resuscitation
- Central Venous Catheters and Hemodialysis
- Palliative Care and End-of-Life Issues
- Anesthesia and Neurotoxicity Research
- Global Maternal and Child Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Bacterial Infections and Vaccines
- Airway Management and Intubation Techniques
- Cystic Fibrosis Research Advances
- Asthma and respiratory diseases
- Mechanical Circulatory Support Devices
- Hemodynamic Monitoring and Therapy
- Neonatal and fetal brain pathology
Amsterdam University Medical Centers
2018-2025
Emma Kinderziekenhuis
2016-2025
University of Amsterdam
2014-2025
Amsterdam Institute for Global Health and Development
2022-2024
Public Health Service of Amsterdam
2024
Amsterdam UMC Location University of Amsterdam
2012-2021
University Medical Center
2021
Respiratory and Meningeal Pathogens Research Unit
2020
National Research Foundation
2020
Wilhelmina Children's Hospital
2020
Acute respiratory distress syndrome (ARDS) is a devastating clinical syndrome. Angiotensin-converting enzyme (ACE) and its effector peptide angiotensin (Ang) II have been implicated in the pathogenesis of ARDS. A counter-regulatory ACE, ie ACE2 that degrades Ang to Ang-(1-7), offers promising novel treatment modality for this As involvement ACE ARDS still unclear, study investigated role these two enzymes an animal model was induced rats by intratracheal administration LPS followed...
Human respiratory syncytial virus (RSV) is the most important cause of severe lower tract disease (LRTD) in young children worldwide. Extensive neutrophil accumulation lungs and occlusion small airways by DNA-rich mucus plugs are characteristic features RSV-LRTD. Activated neutrophils can release extracellular traps (NETs), networks DNA covered with antimicrobial proteins, as part first-line defence against pathogens. NETs trap eliminate microbes; however, abundant NET formation may also...
Results from preclinical studies suggest that age-dependent differences in host defense and the pulmonary renin–angiotensin system (RAS) are responsible for observed epidemiology of acute respiratory distress syndrome (ARDS) between children adults. The present study compares biomarkers RAS bronchoalveolar lavage (BAL) fluid neonates, children, adults, older adults with ARDS. In this prospective observational study, we enrolled mechanical ventilated ARDS patients categorized into four age...
To compare daily sedation interruption plus protocolized (DSI + PS) to only (PS) in critically ill children.In this multicenter randomized controlled trial three pediatric intensive care units the Netherlands, mechanically ventilated children with need for sedative drugs were included. They randomly assigned either DSI PS or only. Children both study arms received adjusted on basis of validated scores. Provided a safety screen was passed, group blinded infusions saline; previous...
ABSTRACT Respiratory syncytial virus (RSV) causes severe respiratory disease in young children. Antibodies specific for the RSV prefusion F protein have guided vaccine research, and human serum, these antibodies contribute to >90% of neutralization response; however, detailed insight into composition B cell repertoire against is still largely unknown. In order study three healthy donors specificity RSV, CD27 + memory cells were isolated immortalized using BCL6 Bcl-xL. Of circulating...
Viral bronchiolitis is the most common cause of respiratory failure requiring invasive ventilation in young children. Bacterial co-infections may complicate and prolong paediatric intensive care unit (PICU) stay. Data on prevalence, type pathogens its association with disease severity are limited though. These data especially important as bacterial be treated using antibiotics could reduce duration PICU We investigated prevalence co-infection stay.Retrospective cohort study ventilated...
To investigate neurocognitive, psychosocial, and quality of life (QoL) outcomes in children with Multisystem Inflammatory Syndrome Children (MIS-C) seen 3-6 months after PICU admission.National prospective cohort study March 2020 to November 2021.Seven PICUs the Netherlands.Children MIS-C (0-17 yr) admitted a PICU.None.Children and/or parents were median (interquartile range [IQR] 4 mo [3-5 mo]) admission. Testing included assessment QoL reference Dutch pre-COVID-19 general population norms....
BACKGROUND: Experimental and clinical evidence suggests that respiratory syncytial virus (RSV) bronchiolitis is an immune mediated disease. Corticosteroids might therefore be effective in the treatment of RSV bronchiolitis. METHODS: A randomised double blind trial was conducted children up to two years age admitted hospital with compare prednisolone (1 mg/ kg/day orally for seven days) placebo. Variables used efficacy analysis were a daily symptom score length time non-ventilated patients,...
Nearly half of all hospitalized infants with respiratory syncytial virus (RSV) lower tract disease (LRTD) are treated (parenteral) antibiotics. The present study was designed to test our hypothesis that the use antibiotics would not lead a reduced duration hospitalization in mild moderate RSV LRTD.Seventy-one patients < or =24 months age virologically confirmed clinical diagnosis LRTD were randomized azithromycin 10 mg/kg/day (n = 32) placebo 39) multicenter, randomized, double-blind,...
<b>Objective</b> To determine whether early initiated anti-inflammatory therapy with prolonged high dose inhaled glucocorticoids influences the occurrence and severity of recurrent wheeze after respiratory syncytial virus related lower tract infections. <b>Design</b> Randomised double blind placebo controlled trial. <b>Setting</b> Paediatric departments 19 Dutch clinical centres. <b>Participants</b> 243 previously healthy infants (126 boys, 117 girls) aged less than 13 months admitted to...
Objective: Angiotensin-converting enzyme and its effector peptide angiotensin II have been implicated in the pathogenesis of acute respiratory distress syndrome. Recently, angiotensin-converting 2 was identified as counter-regulatory that converts into angiotensin-(1-7). The aim this study to determine pulmonary activity patients with Design: Prospective observational pilot study. Setting: A PICU a university hospital. Patients: Fourteen admitted, requiring mechanical ventilation for...
A growing body of evidence suggests that age affects the main pathophysiologic mechanisms acute respiratory distress syndrome. This may imply need for developing age-tailored therapies However, underlying molecular governing age-related susceptibility first to be unraveled. In a rat model lung injury, we investigated whether balance between two key enzymes pulmonary renin-angiotensin system, angiotensin-converting enzyme, and enzyme 2. We hypothesized aging shifts toward injury-promoting...
Neutrophils are the predominant inflammatory cells recruited to respiratory tract as part of innate immune response viral infections. Recent reports indicate existence distinct functional neutrophil subsets in circulatory compartment adults, following severe conditions. Here, we evaluated occurrence blood and broncho-alveolar lavage fluid during infection infants based on CD16/CD62L expression. We show that course may develop four heterogeneous (mature, immature, progenitor, suppressive...
Viral-lower respiratory tract disease is common in young children worldwide and associated with high morbidity. Acute failure due to viral-lower necessitates PICU admission for mechanical ventilation. In critically ill patients settings, early fluid overload adverse outcomes such as prolonged ventilation increased mortality. It unclear, however, if this also applies induced acute failure. study, we aimed investigate the relation of mechanically ventilated a retrospective...
Viral bronchiolitis is a major cause of pediatric intensive care unit (PICU) admission. Insight in the trends bronchiolitis-associated PICU admissions limited, but imperative for future resource and capacity planning.We retrospectively studied six European sites, including three full national registries, between 2000 2019 calculated population-based estimates per 100,000 children where appropriate. Information concerning risk factors severe disease use invasive mechanical ventilation was...
Intensive care is a stressful environment in which team-family conflicts commonly occur. If managed poorly, can have negative effects on all parties involved. Previous studies mainly investigated these and their management retrospective way. This study aimed to prospectively explore conflicts, including its main topics, complicating factors, doctors’ conflict strategies the effect of strategies. Conversations between doctors neonatal, pediatric, adult intensive unit large university-based...
To evaluate the feasibility, reliability, and diagnostic implications of performing pediatric Rapid Ultrasound for Shock Hypotension (p-RUSH) in children with undifferentiated shock upon hospital presentation a low-resource setting (LRS). Prospective observational study from February 2019 to December 2019. Pediatric emergency department (ED) large academic referral Blantyre, Malawi. Children (2 mo 16 yr old) ED. None. Thirty were enrolled, whom 14 died. The p-RUSH was performed admission ED,...
<b>Background:</b> A study was undertaken to evaluate the efficacy of dexamethasone in patients mechanically ventilated for lower respiratory infection caused by syncytial virus (RSV-LRTI). <b>Methods:</b> In a multicentre randomised controlled trial were receive either intravenous (0.15 mg/kg 6 hourly 48 hours) or placebo. End points duration mechanical ventilation, length stay (LOS) pediatric intensive care unit (PICU) and hospital, supplemental oxygen administration. <b>Results:</b>...