A5032782109- Healthcare Systems and Practices
- Health, Medicine and Society
- Pancreatic and Hepatic Oncology Research
- Dementia and Cognitive Impairment Research
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Hepatitis C virus research
- Long-Term Effects of COVID-19
- Cardiac, Anesthesia and Surgical Outcomes
- Alzheimer's disease research and treatments
- Esophageal Cancer Research and Treatment
- Pancreatitis Pathology and Treatment
- Trauma and Emergency Care Studies
- Neurological Disease Mechanisms and Treatments
- Thyroid and Parathyroid Surgery
- Respiratory Support and Mechanisms
- Adrenal and Paraganglionic Tumors
- Diabetes and associated disorders
- Aging, Elder Care, and Social Issues
- Colorectal Cancer Screening and Detection
- Clinical practice guidelines implementation
- Intraperitoneal and Appendiceal Malignancies
- Cerebrovascular and Carotid Artery Diseases
Centre Hospitalier Universitaire de Lille
2016-2025
Université de Lille
2007-2024
Evaluation des technologies de santé et des pratiques médicales
2019-2024
Centre Oscar Lambret
2023-2024
Technologies pour la Santé
2022
Santé Publique France
2011-2020
Inserm
2004-2008
Institut Pasteur de Lille
2004-2008
Institut Pasteur
2008
Institut de Veille Sanitaire
2004-2006
It has been suggested that subcortical lesions may influence cognitive performances at early stages of impairment but not in late dementia. We aimed to test whether decline is associated with hyperintensities patients mild (MCI).We included 170 consecutive MCI (mean follow-up, 3.8+/-1.6 years). assessed on a baseline magnetic resonance imaging scan semiquantitative rating scale. The mean annual was calculated the Mini-Mental State Examination and Dementia Rating Scale end follow-up.Compared...
Background and Purpose— Patients with mild cognitive impairment (MCI) have an increased risk of dementia. The identification predictors conversion to dementia is therefore important. aim our study was test the hypothesis that subcortical hyperintensities (SH) are associated rate in MCI patients. Methods— This observational on consecutive patients attending a memory clinic. We assessed SH baseline MRI scan, using semiquantitative rating scale. A multivariable Cox regression model used...
We tested the hypothesis that a higher education level is associated with faster cognitive decline and lower survival in cohort of 670 Alzheimer's disease patients, followed for 3.5 years at Lille-Bailleul memory centre.The patients were categorized 3 groups according to educational levels: low (<or=8 years), intermediate (9-12 years) high (>12 years). Cognitive function was measured Mini Mental State Examination (MMSE) Mattis Dementia Rating Scale (DRS). Survival analyzed Cox model....
<h3>Objective:</h3> Vascular dementia (VaD) and Alzheimer disease with cerebrovascular (AD+CVD) are the leading causes of after alone (AD). Little is known about progression either VaD or AD+CVD. The aim this study was to compare demographic features, cognitive decline survival patients VaD, AD+CVD AD attending a memory clinic. <h3>Methods:</h3> This included 970 who were followed at Lille-Bailleul clinic, France. Cognitive functions measured Mini Mental State Examination (MMSE) Dementia...
We aimed to examine whether the improved outcome of a digestive cancer procedure in high-volume hospitals is specific or correlates with that other procedures, and determine if discriminant cut-off hospital volume may influence postoperative mortality (POM) regardless procedure.Performing complex surgeries tertiary centers associated outcome. However, association between POM nonspecific procedures unknown.Patients who underwent colectomy, proctectomy, esophagectomy, gastrectomy,...
Viral bronchiolitis is a major cause of pediatric intensive care unit (PICU) admission. Insight in the trends bronchiolitis-associated PICU admissions limited, but imperative for future resource and capacity planning.We retrospectively studied six European sites, including three full national registries, between 2000 2019 calculated population-based estimates per 100,000 children where appropriate. Information concerning risk factors severe disease use invasive mechanical ventilation was...
Background Postoperative pulmonary complications is a major issue that affects outcomes of surgical patients. The hypothesis was the intraoperative ventilation parameters are associated with occurrence postoperative complications. Methods A single-center retrospective cohort study conducted at Lille University Hospital, France. included 33,701 adults undergoing noncardiac, nonthoracic elective surgery requiring general anesthesia tracheal intubation between January 2010 and December 2019....
Abstract Background and Aims Despite the development of medical therapy, nearly 50% patients with Crohn’s disease [CD] undergo surgery during their lifetime. Several studies have suggested some risk factors for postoperative morbidity [POM] after ileocolic resection [ICR]. However, impact surgical hospital volume on POM in CD has not been extensively studied. This study aimed to assess ICR CD. Methods All who underwent France between 2013 2022 were identified French Database, Programme de...
Abstract Aims Mortality risk after hospitalization for heart failure (HF) is high, especially in the first 90 days. This study aimed to construct a model automatically predicting day post‐discharge mortality using electronic health record (EHR) data 48 h admission and artificial intelligence. Methods All HF‐related admissions from 2015 2020 single hospital were included training. Comprehensive EHR collected admission. Natural language processing was applied textual information. Deaths...
In order to evaluate the incidence and risk factors of infection by hepatitis C virus (HCV) among injecting drug users (IDUs), we conducted a prospective cohort study HCV- human immunodeficiency (HIV)-negative IDUs in North East France. A total 231 HCV HIV who had injected drugs at least once their lifetime were followed up every 3 months over 12-month period. Serum anti-HCV anti-HIV tested inclusion end follow-up. Data on practices collected each visit. Of participants included, 165 (71·4%)...
<h3>Importance</h3> The COVID-19 pandemic has posed a number of unprecedented challenges to the health care system in France, where hip fractures elderly population are major public concern. <h3>Objective</h3> To explore association first nationwide lockdown France with absolute among patients 50 years or older. <h3>Design, Setting, and Participants</h3> This retrospective cohort study used data from French national hospitals database identify older who were hospitalized for fracture January...
Objective: Evaluate at a national level the postoperative mortality (POM), major morbidity (MM) and failure-to-rescue (FTR) after cytoreductive surgery (CRS) hyperthermic intraperitoneal chemotherapy (HIPEC) across time according to hospital-volume. Background: CRS/HIPEC is an effective therapeutic strategy commonly used treat peritoneal surface malignancies. However, this aggressive approach has reputation be associated with high POM MM. Methods: All patients treated between 2009 2018 in...
Background: Surgical removal of hyperfunctional parathyroid gland is the definitive treatment for primary hyperparathyroidism (pHPT). Postoperative follow-up shows variability in persistent/recurrent disease rate throughout different centers. Objective: To evaluate incidence redo surgery after targeted parathyroidectomy pHPT. Methods: We performed a nationwide retrospective cohort study on “Programme de Medicalisation des Systemes d’Information,” French administrative database that collects...
Abstract Background No risk stratification tool has been validated in hospitalised patients with coronavirus disease 2019 (COVID‐19), despite a high rate of intensive care requirement and in‐hospital mortality. We aimed to determine whether the National Early Warning Score (NEWS) at admission can accurately predict mortality ICU transfer. Methods This was retrospective cohort study from January 24 April 16, 2020, Lille University Hospital. All consecutive adult laboratory‐confirmed COVID‐19...
Abstract Background Adjuvant chemotherapy (AC) improves the prognosis after pancreatic ductal adenocarcinoma (PDAC) resection. However, previous studies have shown that a large proportion of patients do not receive or complete AC. This national study examined risk factors for omission interruption Methods Data all who underwent surgery PDAC in France between January 2012 and December 2017 were extracted from French National Administrative Database. We considered “omission adjuvant...
To explore the determinants of postoperative outcomes adrenal surgery in order to build a proposition for healthcare improvement.Adrenalectomy is recommended treatment many benign and malignant diseases. Postoperative vary widely literature their remain ill-defined.We based this retrospective cohort study on "Programme de médicalisation des systèmes d'information" (PMSI), national database that compiles discharge abstracts every admission French acute health care facilities. Diagnoses...
Objectives: We aimed to analyze the outcomes of interhospital transfer (IHT) patients after pancreatectomy, describe characteristics transferring hospitals, and determine risk factors mortality in IHT patients. Background: Implementation centralization process is complex currently unrealized France. Alternatively, with postoperative complications high volume centers could reduce (POM) failure rescue (FTR). Methods: All undergoing pancreatectomy for cancer between 2012 2018 were included....
Objective To explore mortality risk factors for patients hospitalised with COVID-19 in a critical care unit (CCU) or hospital (HCU). Design Retrospective cohort analysis using the French national ( Programme de médicalisation des systèmes d’information ) database. Setting Any public private France. Participants 98 366 admitted more than 1 day during first semester of 2020 were included. The underlying conditions retrieved all contiguous stays. Main outcome measures In-hospital and associated...