A5054854459- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- Hepatitis C virus research
- COVID-19 Clinical Research Studies
- HIV Research and Treatment
- Diabetes and associated disorders
- Hepatitis B Virus Studies
- Immunodeficiency and Autoimmune Disorders
- Animal Virus Infections Studies
- Hepatitis Viruses Studies and Epidemiology
- Animal Disease Management and Epidemiology
- Glycosylation and Glycoproteins Research
- Respiratory viral infections research
- Monoclonal and Polyclonal Antibodies Research
- Long-Term Effects of COVID-19
- HIV/AIDS drug development and treatment
- SARS-CoV-2 detection and testing
- T-cell and Retrovirus Studies
- interferon and immune responses
- Herpesvirus Infections and Treatments
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Viral Infections and Outbreaks Research
- Celiac Disease Research and Management
Center for Infection and Immunity of Lille
2014-2024
Institut Pasteur de Lille
2005-2024
Université de Lille
2011-2024
Centre Hospitalier Universitaire de Lille
2009-2024
Centre National de la Recherche Scientifique
2005-2024
Inserm
2014-2024
Institut de Biologie de Lille
2005-2018
Université Lille Nord de France
2010-2014
Lille’s Cardiology Hospital
2014
Groupe Hospitalier de l'Institut Catholique de Lille
2012
One year after the occurrence of first case infection by Middle East Respiratory Syndrome coronavirus (MERS-CoV) there is no clear consensus on best treatment to propose. The World Health Organization, as well several other national agencies, are still working different clinical approaches implement most relevant in MERS-CoV infection. We compared innate and adaptive immune responses two patients infected with understand underlying mechanisms involved response propose potential therapeutic...
Hepatitis C virus (HCV) encodes two viral envelope glycoproteins. E1 contains 4 or 5 N-linked glycosylation sites and E2 up to 11, with most of the being well conserved, suggesting that they play an essential role in some functions these proteins. For this study, we used retroviral pseudotyped particles harboring mutated HCV glycoproteins study glycans. The mutants were named N followed by a number related relative position potential site each glycoprotein (E1N1 E1N4 for E2N1 E2N11 mutants)....
Hepatitis C virus (HCV) envelope glycoproteins are highly glycosylated, with up to 5 and 11 N-linked glycans on E1 E2, respectively. Most of the glycosylation sites HCV conserved, some associated these proteins have been shown play an essential role in protein folding entry. Such a high level suggests that can limit immunogenicity restrict binding antibodies their epitopes. Here, we investigated whether modulate neutralizing activity anti-HCV antibodies. pseudoparticles (HCVpp) bearing...
Long-term care facility (LTCF) older residents display physiological alterations of cellular and humoral immunity that affect vaccine responses. Preliminary reports suggested a low early postvaccination antibody response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The aim this study was to focus on the specific T-cell response. We quantified S1-specific IgG, neutralizing titers, total IFNγ-secreting T cells by ELISpot, functionality CD4 + - CD8 -specific flow...
Co-infection and superinfection of hepatitis B virus (HBV) with delta (HDV) leads to suppression HBV replication both in patients animal cellular models. The mechanisms behind this inhibition have not previously been explored fully. is governed by four promoters two enhancers, Enh1 Enh2. Repression these enhancers has reported be one the main inhibition. Moreover, a previous study, it demonstrated that alpha interferon (IFN-alpha)-inducible MxA protein inhibits replication. HDV encodes...
The association between Cryptosporidium and human colon cancer has been reported in different populations. However, this not well studied. In order to add new strong arguments for a probable link cryptosporidiosis cancer, the aim of study was determine prevalence identify species among Lebanese patients.Overall, 218 digestive biopsies were collected Tripoli, Lebanon, from three groups patients: (i) patients with recently diagnosed intraepithelial neoplasia/adenocarcinoma before any treatment...
The present study aimed to evaluate the persistent immunogenicity offered by a third dose of BNT162b2 against Delta and Omicron variants, in nursing home (NH) residents.In this monocenter prospective observational study, anti-spike IgG levels, S1 domain reactive T cell counts, serum neutralizing antibody titers variants were compared before up three months after booster dose, NH residents without COVID-19 (COVID-19 naive) or with prior initial vaccination recovered).106 (median...
Genome sequencing of virus has become a useful tool for better understanding pathogenicity and epidemiological surveillance. Obtaining genome sequence directly from clinical samples is still challenging task due to the low load genetic material compared host DNA, difficulty get an accurate assembly. Here we introduce complete analyzing protocol called V-ASAP Virus Amplicon Sequencing Assembly Pipeline. Our able generate viral dominant starting samples. It based on multiplex PCR amplicon...
Objective The effectiveness of antiretroviral treatment (ART) was compared in 416 naive patients from a French clinical cohort infected with B and non-B HIV-1 subtypes. Methods Time to HIV viral load (VL) undetectability calculated for each subtype group. Three other parameters were estimated 3, 6 12 months after enrolment: progression (that is, AIDS-defining events or death), changes CD4 cell counts baseline proportion achieving an undetectable VL (<400 HIV-RNA copies/ml). Results In...
The antiviral effect of four porphyrin-based Metal-Organic Frameworks (PMOFs) with Al and Zr, namely Al-TCPP, PCN-222, PCN-223 PCN-224 was assessed for the first time against HCoV-229E, two highly pathogenic coronaviruses (SARS-CoV-2 MERS-CoV) hepatitis C virus (HCV). Infection tests
ABSTRACT Coxsackievirus B4 (CVB4)-induced production of alpha interferon (IFN-α) by peripheral blood mononuclear cells (PBMC) is enhanced in vitro nonneutralizing anti-CVB4 antibodies from healthy subjects and, to a higher extent, patients with insulin-dependent diabetes mellitus. In this study, we focused on identification the viral target these CVB systems. High levels IFN-α were obtained supernatants PBMC incubated CVB4E2 or CVB3 and plasma patients. The VP4 capsid proteins dissociated...
Abstract Background No risk stratification tool has been validated in hospitalised patients with coronavirus disease 2019 (COVID‐19), despite a high rate of intensive care requirement and in‐hospital mortality. We aimed to determine whether the National Early Warning Score (NEWS) at admission can accurately predict mortality ICU transfer. Methods This was retrospective cohort study from January 24 April 16, 2020, Lille University Hospital. All consecutive adult laboratory‐confirmed COVID‐19...
Abstract Although hepatitis E virus (HEV) is the major leading cause of enterically transmitted viral worldwide, many gaps remain in understanding HEV lifecycle. Notably, factories induced by have not been documented yet, and it currently unknown whether infection leads to cellular membrane modeling as positive-strand RNA viruses. genome encodes ORF1 replicase, ORF2 capsid protein ORF3 involved virion egress. Previously, we demonstrated that produces different isoforms including...
Bats are a reservoir for diverse range of viruses, including coronaviruses (CoVs). To determine the presence CoVs in French bats, fecal samples were collected between July and August 2014 from four bat species seven different locations around city Bourges France. We present first time alpha-CoVs Pipistrellus pipistrellus with an estimated prevalence 4.2%. Based on analysis fragment RNA-dependent RNA polymerase (RdRp) gene, phylogenetic analyses show that sequences detected bats closely...