A5020302624- RNA Research and Splicing
- Bacteriophages and microbial interactions
- Protein Kinase Regulation and GTPase Signaling
- Genomics and Phylogenetic Studies
- Plant Virus Research Studies
- Oral and gingival health research
- Microbial Natural Products and Biosynthesis
- Gut microbiota and health
- Viral Infectious Diseases and Gene Expression in Insects
- Microbial Metabolic Engineering and Bioproduction
- RNA modifications and cancer
- Fungal Biology and Applications
- Melanoma and MAPK Pathways
- Genetic factors in colorectal cancer
- Virus-based gene therapy research
- Gene Regulatory Network Analysis
- Bioinformatics and Genomic Networks
- Microbial Metabolism and Applications
- Legume Nitrogen Fixing Symbiosis
- Respiratory viral infections research
- Viral Infections and Immunology Research
- Cardiomyopathy and Myosin Studies
- Plant Physiology and Cultivation Studies
- Tryptophan and brain disorders
- Cytomegalovirus and herpesvirus research
Institut Pasteur de Lille
2019-2025
Inserm
2019-2025
Université de Lille
2019-2025
Centre Hospitalier Universitaire de Lille
2019-2025
Centre National de la Recherche Scientifique
2019-2025
Center for Infection and Immunity of Lille
2019-2021
Université de Toulouse
2018
Université Toulouse III - Paul Sabatier
2018
École Nationale Vétérinaire de Toulouse
2018
Toxalim Research Centre in Food Toxicology
2015-2018
We report the purification of a Ras-GTPase-activating protein (GAP)-binding protein, G3BP, ubiquitously expressed cytosolic 68-kDa that coimmunoprecipitates with GAP. G3BP physically associates SH3 domain GAP, which previously had been shown to be essential for Ras signaling. The cDNA revealed is novel 466-amino-acid shares several features heterogeneous nuclear RNA-binding proteins, including ribonucleoprotein (RNP) motifs RNP1 and RNP2, an RG-rich domain, acidic sequences. Recombinant...
Sam68 is the main tyrosine-phosphorylated and Src-associated protein in mitotic cells. exhibits a conserved functional KH (hnRNPK homology) RNA binding domain binds single strand nucleic acids. Tyrosine phosphorylation mediates interaction of with many SH3- SH2-containing proteins negatively regulates its acid properties. But function impact on cell signaling proliferation remains elusive. We report here identification natural isoform deletion within domain. This isoform, called Sam68ΔKH,...
Aging is a key contributor of morbidity and mortality during acute viral pneumonia. The potential role age-associated dysbiosis on disease outcomes still elusive. In the current study, we used high-resolution shotgun metagenomics targeted metabolomics to characterize SARS-CoV-2-associated changes in gut microbiota from young (2-month-old) aged (22-month-old) hamsters, valuable model COVID-19. We show that age-related dysfunctions are linked severity long-term sequelae older hamsters. Our...
Genome sequencing of virus has become a useful tool for better understanding pathogenicity and epidemiological surveillance. Obtaining genome sequence directly from clinical samples is still challenging task due to the low load genetic material compared host DNA, difficulty get an accurate assembly. Here we introduce complete analyzing protocol called V-ASAP Virus Amplicon Sequencing Assembly Pipeline. Our able generate viral dominant starting samples. It based on multiplex PCR amplicon...
Among challenges that hamper reaping the benefits of genome assembly are both unfinished assemblies and ensuing experimental costs. First, numerous software solutions for de novo available, each having its advantages drawbacks, without clear guidelines as to how choose among them. Second, these produce draft often require a resource intensive finishing phase. In this paper we address two aspects by developing Mix , tool mixes or more assemblies, relying on reference goal reduce contig...
Abstract Aging is a key contributor of morbidity and mortality during acute viral pneumonia. The potential role age-associated dysbiosis on disease outcomes still elusive. In the current study, we used high-resolution shotgun metagenomics targeted metabolomics to characterize SARS-CoV-2-associated changes in gut microbiota from young (2-month-old) aged (22-month-old) hamsters, valuable model COVID-19. We show that age-related dysfunctions are linked severity long-term sequelae older...
Being able to explore the metabolism of broad metabolizing cells is critical importance in many research fields. This article presents an original modeling solution combining metabolic network and omics data identify modulated pathways changes functions occurring during differentiation a human hepatic cell line (HepaRG). Our results confirm activation hepato-specific functionalities newly evidence modulation other pathways, which could not be evidenced from transcriptomic alone. method takes...
ABSTRACT Mycoplasma meleagridis and gallinarum are bacteria that affect birds, but little is known about the genetic basis of their interaction with chickens other poultry. Here, we sequenced genomes M. strain MM_26B8_IPT Mgn_IPT, both isolated from showing respiratory symptoms, poor growth, reduction in hatchability, loss production.