A5055537480- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Tuberculosis Research and Epidemiology
- Travel-related health issues
- COVID-19 Clinical Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV-related health complications and treatments
- Mosquito-borne diseases and control
- Hepatitis Viruses Studies and Epidemiology
- Adolescent Sexual and Reproductive Health
- COVID-19 epidemiological studies
- Hepatitis B Virus Studies
- Disaster Response and Management
- HIV/AIDS Impact and Responses
- Viral Infections and Outbreaks Research
- Trypanosoma species research and implications
- Global Maternal and Child Health
- Long-Term Effects of COVID-19
- Cutaneous lymphoproliferative disorders research
- HIV, Drug Use, Sexual Risk
- Infectious Diseases and Tuberculosis
- Vaccine Coverage and Hesitancy
- Fungal Infections and Studies
- Hepatitis C virus research
Bordeaux Population Health
2012-2024
Centre Hospitalier Universitaire de Bordeaux
2016-2024
MUJHU Research Collaboration
2024
Hôpital Pellegrin
2022
Université de Bordeaux
2012-2021
Programme PAC-CI
2007-2020
Inserm
2007-2020
University Hospital Medical Center at Treichville
2007-2020
Agence Nationale de Recherches sur le Sida et les Hépatites Virales
2020
Hospital for Tropical Diseases
2017
BackgroundTemprano ANRS 12136 was a factorial 2 × trial that assessed the benefits of early antiretroviral therapy (ART; ie, in patients who had not reached CD4 cell count threshold used to recommend starting ART, as per WHO guidelines were standard during study period) and 6-month isoniazid preventive (IPT) HIV-infected adults Côte d'Ivoire. Early ART IPT shown independently reduce risk severe morbidity at 30 months. Here, we present efficacy reducing mortality from long-term follow-up...
HIV is usually associated with weight loss. World health Organization (WHO) recommends early antiretroviral (ART) initiation, but data on the progression of body mass index (BMI) in participants initiating ART Africa are scarce. The Temprano randomized trial was conducted Abidjan to assess effectiveness and Isoniazid (INH) prophylaxis for tuberculosis HIV-infected persons high CD4 counts below 800 cells/mm3 without any indication starting ART. Patients before December 2010 were included this...
BackgroundLassa fever is a viral haemorrhagic endemic in parts of west Africa. New treatments are needed to decrease mortality, but pretrial reference data on the disease characteristics scarce. We aimed document baseline and outcomes for patients hospitalised with Lassa Nigeria.MethodsWe did prospective cohort study (LASCOPE) at Federal Medical Centre Owo, Nigeria. All admitted confirmed were invited participate asked give informed consent. Patients all ages, including newborn infants,...
In human immunodeficiency virus (HIV)-infected patients, hepatitis B (HBV) coinfection increases the risk of disease progression. Tenofovir plus emtricitabine/lamivudine (TDF/XTC)-based antiretroviral therapy (ART), which suppresses HIV and HBV replication, has potential for decreasing this risk. Here, we analyze association between early ART, mortality in West African adults.The Temprano randomized controlled trial assessed benefits immediately initiating vs deferring ART HIV-infected...
Infections are one of the major causes death in patients with advanced-stage mycosis fungoides (MF) or Sézary syndrome (SS). However, few recent data available on characteristics and risk factors these infectious events.To describe events occurring a cohort MF/SS, to identify associated clinical biological factors.A retrospective study was performed investigate diagnosed MF (stage IB beyond) SS followed from May 2011 2016 at University Hospital Bordeaux, France.Seventy-one complete follow-up...
Overall increases in the uptake of HIV testing past two decades might hide discrepancies across socioeconomic groups. We used data from population-based surveys done sub-Saharan Africa to quantify inequalities testing, and establish trends decades.We analysed 16 countries where at least one Demographic Health Survey was before after 2008. assessed country-specific sex-specific proportions participants who had undergone previous 12 months wealth education groups, quantified with both relative...
An increasing number of HIV-infected women become pregnant while receiving efavirenz (EFV). We compared the pregnancy outcomes exposed to EFV and nevirapine (NVP) during first trimester.A retrospective study in 4 HIV care centers participating clinical trials international cohort collaboration. All who conceived on EFV-based or NVP-based antiretroviral therapy (ART) between 2003 2009 were included. Pregnancy as follows: abortion (voluntary termination), miscarriage [unwanted termination <20...
The burden of childhood tuberculosis remains high globally, largely due to under-diagnosis. Decentralising diagnosis services lower health system levels could improve case detection, but there is little empirically based evidence on cost-effectiveness or budget impact.
Background The 2014–2015 Ebola outbreak massively hit Guinea. coastal districts of Boffa, Dubreka and Forecariah, three major foci Human African Trypanosomiasis (HAT), were particularly affected. We aimed to assess the impact this epidemic on sleeping sickness screening caring activities. Methodology/Principal findings used preexisting data from Guinean control program, collected between 2012 2015. described monthly: number persons (i) screened actively; (ii) or passively; (iii) treated for...
In sub-Saharan Africa, most HIV-infected patients receive antiretroviral therapy (ART) without virological monitoring. Longitudinal data on secondary resistance are rare.We conducted a prospective cohort study of HIV-1-infected adults initiating ART in 3 clinics using computerized monitoring systems. Patients had plasma HIV-1 RNA viral load (VL) tests at months 12 (M12) and 24 (M24) after initiation genotype if VL was detectable (≥300 copies/mL).Overall, 1573 initiated with...
Background In Côte d'Ivoire, a TB prison program has been developed since 1999. This includes offering screening to prisoners who show up with symptoms at the infirmary. Our objective was estimate prevalence of pulmonary among inmates Correctional and Detention Facility Abidjan, largest 16 years after this implemented. Methods Between March September 2015, inmates, were screened for using systematic direct smear microscopy, culture chest X-ray. All participants also proposed HIV testing....
Background Initiation of antiretroviral therapy (ART) in all HIV-infected adults, regardless CD4 + T-cell count, is a proposed strategy for reducing HIV transmission. We investigated the conditions under which starting ART early could entail more risks than benefits patients with high counts. Methods used simulation model to compare initiation upon entry care (‘immediate ART') at count ≤350 cells/μl (‘WHO 2010 African adults counts >500 cells/μl. varied inputs determine combination...
Background. Optimal laboratory monitoring of antiretroviral therapy (ART) for human immunodeficiency virus (HIV) remains controversial. We evaluated current and novel strategies in Côte d′Ivoire, West Africa. Methods. used the Cost-Effectiveness Preventing AIDS Complications –International model to compare clinical outcomes, cost-effectiveness, budget impact 11 ART varying by type (CD4 and/or viral load [VL]) frequency. included "adaptive" (biannual then annual patients on ART/suppressed)....
To project the outcomes of using either efavirenz or nevirapine as part initial antiretroviral therapy (ART) in women childbearing age Côte d'Ivoire.We used an HIV computer simulation model to both mother's survival and birth defects at 10 years for a cohort who started ART with nevirapine. The primary outcome was ratio difference number alive cumulative compared In base case analysis, defect rate 2.9% on 2.7% sensitivity analyses, we varied all inputs across confidence intervals reported...
Tenofovir (TDF) with emtricitabine (FTC) and zidovudine (ZDV) is a recognized alternate first-line antiretroviral (ART) regimen for patients who cannot start treatment non-nucleoside reverse transcriptase inhibitors (NNRTIs). Clinical studies comparing TDF+FTC+ZDV to other regimens are lacking. Participants in trial of early ART Côte d'Ivoire (Temprano ANRS 12136) started TDF/FTC plus either efavirenz (EFV) or ZDV (HIV-1+2 dually infected women refusing contraception previously treated...
Objective To explore mortality risk factors for patients hospitalised with COVID-19 in a critical care unit (CCU) or hospital (HCU). Design Retrospective cohort analysis using the French national ( Programme de médicalisation des systèmes d’information ) database. Setting Any public private France. Participants 98 366 admitted more than 1 day during first semester of 2020 were included. The underlying conditions retrieved all contiguous stays. Main outcome measures In-hospital and associated...
Objective To assess the performance of QuantiFERON-TB Gold In-Tube (QFT-GIT) test for active tuberculosis (TB) in HIV adults, and its variation over time patients on antiretroviral therapy (ART) and/or isoniazide preventive (IPT). Methods Transversal study cohort nested Temprano ANRS 12136 randomized controlled trial assessing benefits initiating ART earlier than currently recommended by World Health Organization, with or without a 6-month IPT. Performance QFT-GIT detecting TB at baseline...
Introduction The Temprano and START trials provided evidence to support early ART initiation recommendations. We projected long-term clinical economic outcomes of immediate in Côte d’Ivoire. Methods used a mathematical model compare three potential criteria: 1) CD4 <350/μL (ART<350/μL); 2) <500/μL (ART<500/μL); 3) at presentation (Immediate ART). Outcomes from the included life expectancy, 10-year medical resource use, incremental cost-effectiveness ratios (ICERs) $/year saved (YLS), 5-year...
COVID-19 infection is less severe among children than adults; however, some patients require hospitalization and even critical care. Using data from the French national medico-administrative database, we estimated risk factors for care unit (CCU) admissions pediatric hospitalizations, number characteristics of cases during successive waves January 2020 to August 2021 described death cases.We included all (age < 18) hospitalized with between 1st, 2020, 31st, 2021. Follow-up was until...
Objective: In sub-Saharan Africa, HIV-infected adults who fail second-line antiretroviral therapy (ART) often do not have access to third-line ART. We examined the clinical impact and cost-effectiveness of making ART available in Côte d'Ivoire. Methods: used a simulation model compare 4 strategies after failure: continue (C-ART2), with an adherence reinforcement intervention (AR-ART2), immediate switch (IS-ART3), reinforcement, switching patients persistent failure (AR-ART3). Third-line...
Lassa Fever (LF), is a severe viral disease prevalent in Western Africa. It classified as priority by the World Health Organization (WHO). Ribavirin recommended therapy despite weak evidence of its efficacy. Promising therapeutic agents are becoming available for evaluation human. Before launching trials, we need data on evolution under best possible conditions care. We have initiated prospective study Nigeria to better understand clinical course and prognostic factors LF while implementing...
Literature on health events in HIV-infected travellers is scarce, particularly sub-Saharan African (SSA) migrants.We investigated SSA migrants living France during and after travel to their native country. All had a pre-travel plasma viral load (pVL) below 200 copies/mL were stable combined antiretroviral therapy (cART). Logistic regression models used assess the risk factors for at least one adverse event or febrile event.Among 264 HIV migrants, median CD4 count was 439/mm3 27 (6%)...
SETTING: TEMPRANO was a multicentre, open-label trial in which human immunodeficiency virus (HIV) infected adults with high CD4 counts were randomised into early or deferred antiretroviral therapy (ART) arms without 6-month isoniazid preventive (IPT) setting where the World Health Organization (WHO) recommends IPT HIV-infected patients. Despite WHO recommendation, coverage remains low due to fear of presence undiagnosed active TB before prescribing IPT, and related risk drug...