Stephan Günther
A5051191695- Viral Infections and Outbreaks Research
- Viral Infections and Vectors
- Hepatitis B Virus Studies
- Disaster Response and Management
- Mosquito-borne diseases and control
- Viral gastroenteritis research and epidemiology
- Bacillus and Francisella bacterial research
- Hepatitis C virus research
- COVID-19 epidemiological studies
- Carcinogens and Genotoxicity Assessment
- SARS-CoV-2 and COVID-19 Research
- Liver Disease Diagnosis and Treatment
- Zoonotic diseases and public health
- Effects of Radiation Exposure
- DNA Repair Mechanisms
- Vector-Borne Animal Diseases
- Radiation Dose and Imaging
- Virus-based gene therapy research
- Malaria Research and Control
- Animal Virus Infections Studies
- Molecular Biology Techniques and Applications
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Bacteriophages and microbial interactions
- Plant Virus Research Studies
Bernhard Nocht Institute for Tropical Medicine
2015-2024
German Center for Infection Research
2014-2024
Universität Hamburg
1996-2024
Johannes Gutenberg University Mainz
1983-2024
Deutsches Elektronen-Synchrotron DESY
2024
Center for Free-Electron Laser Science
2024
Klinik und Poliklinik für Frauenheilkunde und Fortpflanzungsmedizin
2024
Irrua Specialist Teaching Hospital
2016-2023
Jena University Hospital
2023
Max Planck Institute for Heart and Lung Research
2013-2022
BackgroundAbstractThe severe acute respiratory syndrome (SARS) has recently been identified as a new clinical entity. SARS is thought to be caused by an unknown infectious agent.MethodsClinical specimens from patients with were searched for viruses the use of cell cultures and molecular techniques.ResultsA novel coronavirus was in SARS. The virus isolated culture, sequence 300 nucleotides length obtained polymerase-chain-reaction (PCR)–based random-amplification procedure. Genetic...
In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratorysyndrome (SARS). The sequence the complete genome SARS-CoV determined, and initial characterization viral is presented this report. 29,727 nucleotides length has 11 open reading frames, its organization similar to that other coronaviruses. Phylogenetic analyses comparisons showed not closelyrelated anyof previouslycharacterized
In March 2014, the World Health Organization was notified of an outbreak a communicable disease characterized by fever, severe diarrhea, vomiting, and high fatality rate in Guinea. Virologic investigation identified Zaire ebolavirus (EBOV) as causative agent. Full-length genome sequencing phylogenetic analysis showed that EBOV from Guinea forms separate clade relationship to known strains Democratic Republic Congo Gabon. Epidemiologic linked laboratory-confirmed cases with presumed first...
rVSV-ZEBOV is a recombinant, replication competent vesicular stomatitis virus-based candidate vaccine expressing surface glycoprotein of Zaire Ebolavirus. We tested the effect in preventing Ebola virus disease contacts and recently confirmed cases Guinea, west Africa.
ABSTRACT Viral hemorrhagic fevers (VHFs) are acute infections with high case fatality rates. Important VHF agents Ebola and Marburg viruses (MBGV/EBOV), Lassa virus (LASV), Crimean-Congo fever (CCHFV), Rift Valley (RVFV), dengue (DENV), yellow (YFV). VHFs clinically difficult to diagnose distinguish; a rapid reliable laboratory diagnosis is required in suspected cases. We have established six one-step, real-time reverse transcription-PCR assays for these pathogens based on the Superscript...
Current knowledge of hepatitis B virus (HBV) sequence heterogeneity is based mainly on sequencing amplified subgenomic HBV fragments. Here, we describe a method which allows sensitive amplification and simplified functional analysis full-length genomes with or without prior cloning. By this method, large number were cloned from sera six immunosuppressed kidney transplant patients. Two size classes genomes, one 3.2 kb another about 2.0 in size, found all The genome population serum sample was...
Outbreaks of Ebola hemorrhagic fever in sub-Saharan Africa are associated with case fatality rates up to 90%. Currently, neither a vaccine nor an effective antiviral treatment is available for use humans. Here, we evaluated the efficacy pyrazinecarboxamide derivative T-705 (favipiravir) against Zaire virus (EBOV) vitro and vivo. suppressed replication EBOV cell culture by 4log units IC90 110μM. Mice lacking type I interferon receptor (IFNAR(-)(/)(-)) were used as vivo model EBOV-induced...
ABSTRACT Virus-infected cells secrete a broad range of interferons (IFN) which confer resistance to yet uninfected by triggering the synthesis antiviral factors. The relative contributions various IFN subtypes innate immunity against virus infections remain elusive. IFN-α, IFN-β, and other type I molecules signal through common, universally expressed cell surface receptor, whereas III (IFN-λ) uses distinct cell-type-specific receptor complex for signaling. Using mice lacking functional...
The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating tremendous human suffering. To date, no effective drug available to directly treat the disease. In a search for against COVID-19, we have performed high-throughput x-ray crystallographic screen of two repurposing libraries main protease (M
Ebola virus disease (EVD) developed in a patient who contracted the Sierra Leone and was airlifted to an isolation facility Hamburg, Germany, for treatment. During course of illness, he had numerous complications, including septicemia, respiratory failure, encephalopathy. Intensive supportive treatment consisting high-volume fluid resuscitation (approximately 10 liters per day first 72 hours), broad-spectrum antibiotic therapy, ventilatory support resulted full recovery without use...
The 2018 Nigerian Lassa fever season saw the largest ever recorded upsurge of cases, raising concerns over emergence a strain with increased transmission rate. To understand molecular epidemiology this upsurge, we performed, for first time at epicenter an unfolding outbreak, metagenomic nanopore sequencing directly from patient samples, approach dictated by highly variable genome target pathogen. Genomic data and phylogenetic reconstructions were communicated immediately to authorities World...
We report on an Ebola virus disease (EVD) survivor who showed in seminal fluid 531 days after onset of disease. The persisting was sexually transmitted February 2016, about 470 symptoms, and caused a new cluster EVD Guinea Liberia.
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We report on a measurement of the parity-violating asymmetry in scattering longitudinally polarized electrons unpolarized protons at Q2 0.230 (GeV/c)(2) and angle theta (e) = 30 degrees - 40 degrees. Using large acceptance fast PbF2 calorimeter with solid delta omega 0.62 sr, A4 experiment is first parity violation to count individual events. The measured A(phys)=(-5.44+/-0.54(stat)+/-0.26(sys))x10(-6). standard model expectation assuming no strangeness contributions vector form factors A(0)...