Hilde De Clerck

ORCID: 0000-0003-0145-4242
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About
Contact & Profiles
Research Areas
  • Viral Infections and Outbreaks Research
  • Viral Infections and Vectors
  • Disaster Response and Management
  • COVID-19 epidemiological studies
  • Hepatitis B Virus Studies
  • Legal Issues in South Africa
  • Viral gastroenteritis research and epidemiology
  • Global Maternal and Child Health
  • Health and Conflict Studies
  • Lipoproteins and Cardiovascular Health
  • COVID-19 and healthcare impacts
  • Regulation and Compliance Studies
  • Philosophy, Sociology, Political Theory
  • Respiratory viral infections research
  • Comparative and International Law Studies
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • Orthodontics and Dentofacial Orthopedics
  • Psychoanalysis and Psychopathology Research
  • Mosquito-borne diseases and control
  • Global Security and Public Health
  • Zoonotic diseases and public health
  • dental development and anomalies
  • Disaster Management and Resilience
  • Delphi Technique in Research
  • Corporate Law and Human Rights

Médecins Sans Frontières
2014-2022

Médecins Sans Frontières
2019

Medscape
2016

University of California, Irvine
2016

Instituut voor Tropische Geneeskunde
2016

Donka Hospital
2016

National Blood Transfusion Service
2016

University of Liverpool
2016

Médecins Sans Frontières
2015

Cambodia-Oxford Medical Research Unit
2010

In March 2014, the World Health Organization was notified of an outbreak a communicable disease characterized by fever, severe diarrhea, vomiting, and high fatality rate in Guinea. Virologic investigation identified Zaire ebolavirus (EBOV) as causative agent. Full-length genome sequencing phylogenetic analysis showed that EBOV from Guinea forms separate clade relationship to known strains Democratic Republic Congo Gabon. Epidemiologic linked laboratory-confirmed cases with presumed first...

10.1056/nejmoa1404505 article EN New England Journal of Medicine 2014-04-16

10.1038/nature17949 article EN Nature 2016-05-03

A neonate born to an Ebola virus-positive woman was diagnosed with virus infection on her first day of life. The patient treated monoclonal antibodies (ZMapp), a buffy coat transfusion from survivor, and the broad-spectrum antiviral GS-5734. On 20, venous blood specimen tested negative for by quantitative reverse-transcription polymerase chain reaction. discharged in good health 33 Further follow-up consultations showed age-appropriate weight gain neurodevelopment at age 12 months. This is...

10.1093/infdis/jiw493 article EN cc-by The Journal of Infectious Diseases 2016-10-19

This paper describes patient characteristics, including Ebola viral load, associated with mortality in a Médecins Sans Frontières case management centre (CMC).Out of 780 admissions between June and October 2014, 525 (67%) were positive for known outcome. The crude rate was 51% (270/525). load (whole-blood sample) data available on 76% (397/525) patients. Univariate analysis indicated at admission, age, symptom duration prior to distance traveled the CMC (P < .05). multivariable model...

10.1093/infdis/jiv304 article EN cc-by-nc-nd The Journal of Infectious Diseases 2015-05-22

Background. A unit of the European Mobile Laboratory (EMLab) consortium was deployed to Ebola virus disease (EVD) treatment in Guéckédou, Guinea, from March 2014 through 2015. Methods. The diagnosed EVD and malaria, using RealStar Filovirus Screen reverse transcription–polymerase chain reaction (RT-PCR) kit a malaria rapid diagnostic test, respectively. Results. cleaned EMLab database comprised 4719 samples 2741 cases suspected Guinea. 1231 2178 hospitalized patients (57%) 281 563 who died...

10.1093/infdis/jiw269 article EN cc-by-nc-nd The Journal of Infectious Diseases 2016-09-16

Background. Reliable reverse transcription polymerase chain reaction (RT-PCR)–based diagnosis of Ebola virus infection currently requires a blood sample obtained by intravenous puncture. During the current outbreak in Guinea, we evaluated usability capillary samples collected from fingersticks patients suspected having disease (EVD) for field diagnostics during an emergency.

10.1093/cid/civ397 article EN cc-by-nc-nd Clinical Infectious Diseases 2015-05-19

Outbreaks of Ebola and Marburg virus diseases have recently increased in frequency Uganda. This increase is probably caused by a combination improved surveillance laboratory capacity, contact between humans the natural reservoir viruses, fluctuations viral load prevalence within this reservoir. The roles these proposed explanations must be investigated order to guide appropriate responses changing epidemiological profile. Other African settings which multiple filoviral outbreaks occurred...

10.4269/ajtmh.13-0374 article EN other-oa American Journal of Tropical Medicine and Hygiene 2014-02-11

By using data from a 2015 clinical trial on Ebola convalescent-phase plasma in Guinea, we assessed the prevalence of electrolyte and metabolic abnormalities at admission their predictive value to stratify patients into risk groups. Patients underwent testing with point-of-care device. We used logistic regression construct prognostic model summarized area under receiver operating curve. Abnormalities were common among patients, particularly hypokalemia, hypocalcemia, hyponatremia, raised...

10.3201/eid2212.161136 article EN cc-by Emerging infectious diseases 2016-11-17

Only one recommendation currently exists for the treatment of Lassa fever (LF), which is ribavirin administered in conjunction with supportive care. This primarily based on evidence generated from a single clinical trial that was conducted more than 30 years ago-the methodology and results have recently come under scrutiny. The requirement novel therapeutics reassessment therefore urgent. However, significant amount work now needs to be undertaken ensure future trials LF can consistently...

10.1371/journal.pntd.0010089 article EN cc-by PLoS neglected tropical diseases 2022-01-06

The capacity to rapidly distinguish Ebola virus disease from other infectious diseases and monitor biochemistry viremia levels is crucial the clinical management of suspected cases. This article describes design practical considerations a laboratory straddling high- low-risk zones an treatment center produce timely diagnostic results for informed case in real-life conditions. innovation may be relevance actors requiring flexible implementation contexts high-communicability, high-lethality outbreaks.

10.1017/dmp.2019.39 article EN Disaster Medicine and Public Health Preparedness 2019-06-24

Abstract: Médecins Sans Frontières (MSF)/Doctors Without Borders, an International Medical Humanitarian Non Governmental Organization, has experience of 20 years in intervening Viral Hemorrhagic Fever (VHF) Outbreaks (Marburg-, Ebola-, Lassa-fever- outbreaks). Healthcare providers caring for Marburg-, and, a lesser extend, Lassa-patients, are, next to family and friends patients, at highest risk getting infected by those diseases, as they are most likely come contact with infectious blood...

10.1016/j.ijid.2016.02.194 article EN cc-by-nc-nd International Journal of Infectious Diseases 2016-03-28

Einführung: Die temporäre skelettale Verankerung ist eine relativ junge kieferorthopädische ­Behandlungsmaßnahme. Dabei sind chirurgische Osteosyntheseplatten, die mit intraoralen Attachments versehen sind, Alternative zu Minischrauben. In der vorliegenden Studie wurde Verwendung von modifizierten Osteosyntheseplatten für Behandlung aus Sicht Patienten und Behandlern untersucht. Methoden: Patienten, bei denen Miniplatten als Teil kieferorthopädischen ein­gesetzt worden waren, wurden anhand...

10.1055/s-0028-1098939 article DE Informationen aus Orthodontie & Kieferorthopädie 2009-06-01

Abstract: (no abstract received from presenter)

10.1016/j.ijid.2016.02.061 article EN cc-by-nc-nd International Journal of Infectious Diseases 2016-03-29

Introduction: malgré la réduction globale de mortalité des moins 5 ans, celle néonatale, due principalement à l’asphyxie naissance demeure inacceptablement élevée surtout en Afrique Sub-Saharienne. Ce problème peut être combattu par une amélioration compétences agents accoucheurs. Nous présentons ici les résultats préliminaires d’une étude pilote qui a pour but former santé première ligne du Burkina Faso réanimation néonatale base (RNB).

10.11604/pamj.cp.2018.9.18.745 article FR Pan African Medical Journal Conference Proceedings 2018-01-01
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