A5047084155- French Urban and Social Studies
- Retinal Diseases and Treatments
- Cultural Insights and Digital Impacts
- Cultural Identity and Heritage
- Linguistics and Discourse Analysis
- Protease and Inhibitor Mechanisms
- Canadian Identity and History
- Historical and Literary Studies
- Neurological Disease Mechanisms and Treatments
- Historical Studies and Socio-cultural Analysis
- Museums and Cultural Heritage
- Education, sociology, and vocational training
- Angiogenesis and VEGF in Cancer
- Multiculturalism, Politics, Migration, Gender
- Diverse Cultural and Historical Studies
- French Language Learning Methods
- Literature and Culture Studies
- Glaucoma and retinal disorders
- Aging, Elder Care, and Social Issues
- Metabolomics and Mass Spectrometry Studies
- Historical and Literary Analyses
- Blood Coagulation and Thrombosis Mechanisms
- Retinal Imaging and Analysis
- Retinoids in leukemia and cellular processes
- Psychoanalysis and Psychopathology Research
University of Liège
2010-2025
Sens, Texte, Informatique, Histoire
2022
Bibliothèque Nationale du Royaume du Maroc
2022
Université Côte d'Azur
2022
Médecins Sans Frontières
2013-2020
Centre Hospitalier Universitaire de Liège
2010-2019
Laboratoire des Sciences de l’Information et de la Communication
2019
Institut de Neurobiologie de la Méditerranée
2018
Centre Hospitalier Andrée Rosemon
2018
Observatoire de la Côte d’Azur
2018
Peripartum cardiomyopathy (PPCM) is a life-threatening pregnancy-associated in previously healthy women. Although PPCM driven part by the 16-kDa N-terminal prolactin fragment (16K PRL), underlying molecular mechanisms are poorly understood. We found that 16K PRL induced microRNA-146a (miR-146a) expression ECs, which attenuated angiogenesis through downregulation of NRAS. stimulated release miR-146a-loaded exosomes from ECs. The were absorbed cardiomyocytes, increasing miR-146a levels,...
Background MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that regulate gene expression at post-transcriptional level. The recent discovery of the involvement these in control angiogenesis renders them very attractive development new approaches for restoring angiogenic balance. Whereas miRNA-21 has been demonstrated to be highly endothelial cells, potential function this miRNA never investigated. Methodology/Principal Findings We first observed cells a negative...
VEGF has been shown to be necessary, but not sufficient alone, for the development of subretinal pathologic angiogenesis. In current study, influence placental growth factor (PlGF), a member family, in human and experimental choroidal neovascularization (CNV) was investigated.The presence family mRNA evaluated by RT-PCR neovascular membranes extracted during surgery. The spatial temporal pattern isoforms PlGF expression were explored using laser capture catapulting technique murine...
Matrix metalloproteinase 2 (MMP-2) and MMP-9 are increased in human choroidal neovascularization (CNV) occurring during the exudative most aggressive form of age-related macular degeneration (AMD), but their precise role potential interactions remain unclear. To address question MMP-2 functions, mice deficient expression (MMP-2 KO), (MMP-9 both (MMP-2,9 KO) with corresponding wild-type (WT) underwent CNV induction by laser-induced rupture Bruch's membrane. Both incidence severity were...
Recent studies have demonstrated the existence of two oestrogen receptor subtypes alpha (ORalpha) and beta (ORbeta) with significant differences expression among organs. Since important pathologies human eye could be linked to hormonal status, ORbeta in ocular posterior segment was sought.Immunohistochemical localisation ORalpha protein detection OR mRNAs by reverse transcription-polymerase chain reaction (RT-PCR) were performed macular extramacular regions retina choroid on male female...
Human immunodeficiency virus (HIV) remains an important cause of hospitalization and death in low- middle- income countries. Yet morbidity in-hospital mortality patterns remain poorly characterized, with prior antiretroviral therapy (ART) exposure treatment failure status largely unknown.
Purpose.: To evaluate the antilymphangiogenic potential of multi-target tyrosine kinase inhibitor sunitinib in corneal neovascularization (NV). Methods.: Inflammatory NV was induced by thermal cauterization applied central cornea mice, to which malate daily administered gavage or not. At days 6, 11, 17 post cauterization, lymphatic and blood vessels, as well inflammatory cells were immunostained quantified whole-mounted corneas. RT-PCRs performed evidence VEGF–A, VEGF-C, VEGF-D, placental...
In Burundi, the annual incidence of obstetric fistula is estimated to be 0.2-0.5% all deliveries, with 1000–2000 new cases per year. Despite this relatively high incidence, national capacity for identifying and managing very limited. Thus, in July 2010, Medecins Sans Frontieres (MSF) set up a specialised Obstetric Fistula Centre Gitega (Gitega Centre, GFC), only permanent referral centre Burundi. A comprehensive model care offered including psychosocial support, conservative surgical...
High levels of the plasminogen activators, but also their inhibitor, activator inhibitor 1 (PAI-1), have been documented in neovascularization severe ocular pathologies such as diabetic retinopathy or age-related macular degeneration (AMD). AMD is primary cause irreversible photoreceptors loss, and current therapies are limited. PAI-1 has recently shown to be essential for tumoral angiogenesis. We report here that deficient expression mice prevented development subretinal choroidal...
Introduction This study applies NMR-based metabolomics to investigate neovascular age-related macular degeneration (nAMD), addressing challenges in patient management, disease progression evaluation, and treatment response assessment. A two-year follow-up of 29 nAMD patients undergoing provided 231 time points for analysis. Methods Over the period, 11 males 18 females (aged 61–92 years) were monitored, yielding points. At each point, blood samples NMR analysis, clinical measurements (e.g.,...
ABSTRACT Introduction As a complement to the classic metabolomics biofluid studies, visualisation of metabolites contained in cells or tissues could be very powerful tool understand how local metabolism and biochemical pathways affected by external internal stimuli pathologies. Therefore, extraction and/or lysis is necessary obtain samples adapted for use with current analytical tools (liquid NMR MS). These work‐ups are often most labour‐intensive rate‐limiting steps metabolomics, as they...
To evaluate the presence and potential involvement of members plasminogen/plasminogen activator (Plg/PA) system in exudative form age-related macular degeneration (AMD).The expression PA mRNA was evaluated human experimental choroidal neovascularization (CNV) by RT-PCR. The activity studied immunofluorescence situ zymography. influence endogenous plasminogen (Plg), urokinase (uPA), tissue type (tPA), uPA receptor (uPAR) explored single-gene-deficient mice a model laser-induced CNV.Members...
Connective tissue growth factor (CTGF) is a member of the CCN family factors. CTGF important in scarring, wound healing, and fibrosis. It has also been implicated to play role angiogenesis, addition vascular endothelial (VEGF). In eye, angiogenesis subsequent fibrosis are main causes blindness conditions such as diabetic retinopathy. We have applied three different models homozygous −/− heterozygous +/− mice establish involvement neovascularization. die around birth. Therefore, embryonic ,...
To explain the conflicting reports about influence of plasminogen activator inhibitor type (PAI-1) on pathologic angiogenesis, such as occurs during exudative form age-related macular degeneration.The expression PAI-1 mRNA was analyzed in human and murine choroidal neovascularization (CNV) by RT-PCR. The influences increasing doses recombinant were evaluated daily intraperitoneal injections PAI-1(-/-) wild-type animals with a model laser-induced CNV. double mechanism action (proteolytic...
In this study we used duck hepatitis B virus (DHBV)-infected Pekin ducks and heron (HHBV)-infected tissue to search for epitopes responsible neutralization on pre-S proteins. Monoclonal antibodies were produced by immunizing mice with purified DHBV particles. Of 10 anti-DHBV specific hybridomas obtained, 1 was selected study. This monoclonal antibody recognized in both DHBV-infected livers viremic sera a major (36-kilodalton) protein several minor proteins all seven strains used. contrast,...
Outcomes of sexual violence care programmes may vary according to the profile survivors, type suffered, and local context. Analysis existing services could lead their better adaptation contexts. We therefore set out compare Médecins Sans Frontières in Democratic Republic Congo (DRC) a zone conflict (Masisi, North Kivu) post-conflict (Niangara, Haut-Uélé).A retrospective descriptive cohort study, using routine programmatic data from MSF Masisi Niangara, DRC, for 2012.In Masisi, 491 survivors...