A5001774072- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Pancreatic and Hepatic Oncology Research
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Angiogenesis and VEGF in Cancer
- Cancer Cells and Metastasis
- Helicobacter pylori-related gastroenterology studies
- Cancer, Hypoxia, and Metabolism
- Gastroesophageal reflux and treatments
- Immune cells in cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genetic factors in colorectal cancer
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Phagocytosis and Immune Regulation
- Diet and metabolism studies
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- RNA modifications and cancer
University Hospital Cologne
2020-2025
Heidelberg University
2015-2024
University Hospital Heidelberg
2015-2024
University of Cologne
1983-2024
Klinik und Poliklinik für Psychosomatik und Psychotherapie
2021-2024
Universitätsklinik für Chirurgie Wien
2024
University Medical Centre Mannheim
2024
KU Leuven
2008-2023
LVR-Klinik Köln
2010-2023
Israelitisches Krankenhaus
2023
Cancer-associated fibroblasts (CAF) may exert tumor-promoting and tumor-suppressive functions, but the mechanisms underlying these opposing effects remain elusive. Here, we sought to understand potentially functions by interrogating functional relationships among CAF subtypes, their mediators, desmoplasia, tumor growth in a wide range of types metastasizing liver, most common organ site for metastasis. Depletion hepatic stellate cells (HSC), which represented main source mice patients our...
The concept of inhibiting tumor neovessels has taken the hurdle from bench to bedside and now represents an extra pillar anticancer treatment. So far, anti-angiogenic therapy prolongs survival in order months some settings while failing induce a benefit others, part because intrinsic refractoriness or evasive escape. This review provides update on recent mechanisms via which stromal cells resistance discusses evolutions (pre)clinical development novel third-generation agents overcome this problem.
Only 30% of patients with elevated serum prostate specific antigen (PSA) levels who undergo biopsy are diagnosed cancer (PCa). Novel methods needed to reduce the number unnecessary biopsies. We report on identification and validation a panel 12 novel biomarkers for (PCaP), using CE coupled MS. The could be defined by comparing first void urine 51 men PCa 35 negative biopsy. In contrast, midstream samples did not allow discriminatory molecules, suggesting that prostatic fluids may source...
Recently, histopathological tumour regression, prevalence of signet ring cells, and localisation were reported as prognostic factors in neoadjuvantly treated oesophagogastric (junctional gastric) cancer. This exploratory retrospective study analyses independent within a large patient cohort after preoperative chemotherapy including clinical factors.In all, 850 patients presenting with cancer staged cT3/4 Nany cM0/x neoadjuvant followed by resection two academic centres. Patient data...
Matrixmetalloproteinases (MMPs) comprise a family of zinc-dependent endopeptidases which are involved in angiogenesis, tumor invasion and metastatic formation. Up to date, the prognostic relevance MMPs serum patients with colon cancer remains unknown. Thus, we wanted assess an expression pattern homogenous cohort their potential as biomarkers. Differences MMP7, MMP10 MMP12 78 specimens adenocarcinoma healthy control group were assessed using Luminex-100 technologies. Subsequently, correlated...
Nuclear cotranslocation with STAT3 enables YAP/TAZ to activate genes involved in tumor vascularization.
Abstract Epstein–Barr virus positivity (EBV(+)) and high‐microsatellite instability (MSI‐H) have been identified as molecular subgroups in gastric carcinoma. The aim of our study was to determine the prognostic predictive relevance these context platinum/5‐fluorouracil (5‐FU) based preoperative chemotherapy (CTx). Additionally, we investigated clinical low‐MSI (MSI‐L) phenotype. We analysed 760 adenocarcinomas stomach or gastro‐oesophageal junction encompassing 143 biopsies before CTx 617...
Abstract The characteristic desmoplastic stroma of pancreatic ductal adenocarcinoma (PDAC) is a key contributor to its lethality. This stromal microenvironment populated by cancer-associated fibroblasts (CAFs) that interact with cancer cells drive progression and chemo-resistance. Research has focused on CAFs in the primary tumour but not metastases, calling into question role analogous metastasis-associated (MAFs). We infer MAFs murine hepatic metastases following untargeted treatment...
To evaluate the effectiveness and safety of infrahepatic inferior vena cava (IVC) clamping for reduction central venous pressure (CVP) blood loss during hepatic resection.Low CVP parenchymal transection has been widely accepted to reduce intraoperative hemorrhage via veins is commonly achieved by anesthesiological interventions such as fluid restriction. We hypothesized that IVC may lower more effectively and, moreover, prevent potential adverse effects restriction hemodynamic...