A5100330589- Cytokine Signaling Pathways and Interactions
- Mesenchymal stem cell research
- Connective tissue disorders research
- Bone Metabolism and Diseases
- IL-33, ST2, and ILC Pathways
- Cleft Lip and Palate Research
- Hippo pathway signaling and YAP/TAZ
- Biomarkers in Disease Mechanisms
- Neonatal Respiratory Health Research
- Transplantation: Methods and Outcomes
- Macrophage Migration Inhibitory Factor
- Stress Responses and Cortisol
- Wnt/β-catenin signaling in development and cancer
- Neurogenetic and Muscular Disorders Research
- dental development and anomalies
- Craniofacial Disorders and Treatments
- Natural product bioactivities and synthesis
- Reproductive System and Pregnancy
- Tissue Engineering and Regenerative Medicine
- Flavonoids in Medical Research
- Phytochemical compounds biological activities
- Organ and Tissue Transplantation Research
- Respiratory Support and Mechanisms
- Lipid metabolism and disorders
- Synthesis of Organic Compounds
Tianjin Medical University
2009-2023
Tianjin First Center Hospital
2023
Chinese People's Liberation Army
2020
Chinese PLA General Hospital
2020
Lanzhou Army General Hospital
2009-2016
Qilu Hospital of Shandong University
2016
Xi'an Jiaotong University
2015
Tianjin Medical University General Hospital
2010
Tianjin Stomatological Hospital
2009-2010
Nuclear cotranslocation with STAT3 enables YAP/TAZ to activate genes involved in tumor vascularization.
Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) characterized by chronic inflammation colon. It commonly believed that the imbalance immune system and overwhelming production cytokines are involved in pathogenesis UC. Recent studies demonstrated interleukin-35 (IL-35), key player regulation inflammation, has been identified as potential therapeutic target to treat However, conventional intravenous administration costly inconvenient. The present study was designed...
A set of novel trans-tiliroside derivatives were synthesized. The structures the identified by their IR, 1H-NMR, and MS spectra analysis. Their anti-diabetic activities evaluated on insulin resistant (IR) HepG2 cell model. As a result, compounds 7a, 7c, 7h, exhibited significant glucose consumption-enhancing effects in IR-HepG2 cells compared with positive control (metformin). This research provides useful clues for further design discovery agents.
Angiopoietin-1 (Ang1) is a critical factor for vascular stabilization and endothelial survival via inhibition of permeability leukocyte- endothelium interactions. Hence, we hypothesized that treatment with umbilical cord mesenchymal stem cells (UCMSCs) carrying the Ang1 gene (UCMSCs-Ang1) might be potential approach acute lung injury (ALI) induced by lipopolysaccharide (LPS). UCMSCs or without transfection human were delivered intravenously into rats one hour after intra-abdominal...
Osteogenesis imperfecta (OI) is a rare genetic disorder characterized by bone fragility and deformity. Mesenchymal stem cells (MSCs) infusion can improve performance mainly due to their differentiation into osteoblasts in OI therapy. The osteoinductive activity of NELL1 have benefited various defect osteoporotic models promoting formation. present study investigated the efficacy combined use adipose-derived mesenchymal (ADSCs) treatment. Lentiviral vector carrying mouse Nell1 gene was...
The dried roots of Scutellaria baicalensis Georgi, is known in traditional Chinese medicine as Huang Qin (H. qin), and it has been officially traditionally used treatment various diseases such hepatitis China. Baicalein (BA), a flavonoid originally isolated from H. qin, shown wide range biological activities. This study was to evaluate whether baicalein, can reduce the intestinal mucosal cell apoptosis caused by cirrhotic endotoxemia its possible mechanisms. For this purpose, compound...
The aim of this study was to explore the genetic basis non-syndromic tooth agenesis (TA) in a Chinese family five individuals using whole-exome sequencing (WES) analysis.Five participants/Family-based TA proband.The proband, proband's mother and grandmother displayed congenital deficiency. Genomic DNA extracted from peripheral blood or saliva samples her parents grandmother, WES utilized identify causal mutation. identified mutation further verified by Sanger analysed bioinformatics tools.A...
ABSTRACT Osteogenesis imperfecta (OI) is a congenital genetic disorder mainly manifested as bone fragility and recurrent fracture. Mutation of COL1A1/COL1A2 genes encoding the type I collagen are most responsible for clinical patients. Allogenic mesenchymal stem cells (MSCs) provide potential to treat OI through differentiation into osteoblasts. Autologous defective MSCs have not been utilized in treatment because their impaired osteogenesis, but latent mechanism has well understood. Here,...
Abstract Recent data have redefined the concept of inflammation as a critical component tumor progression. However, there has been little development on cases where or near wound and exist simultaneously. Therefore, this pilot study aims to observe impact tumor, build new mouse model with manufactured surgical representing acute inflammation, evaluate relationship between healing process growth. We focus two phases that are present when influences tumor. In early phase, inhibitory effects...
Learning points for clinicians PARN-like ribonuclease domain-containing exonuclease 1 (PNLDC1) forms a trimmer of piRNAs mediating 3'-splicing and plays an important role in meiosis spermatogenesis. Here, we identified novel nonsense PNLDC1 variant patient with Oligo-astheno-teratozoospermia (OAT) poor clinical outcomes intracytoplasmic sperm injection (ICSI) from consanguineous Chinese family.
Abstract Mutations of MSX1 have been associated with nonsyndromic hypodontia. To seek the causal gene mutation sites in a family oligodontia, whole‐exome sequencing (WES) was performed to causative locus family. The candidate further identified by Sanger afterward. Two mutations were found both proband and her mother. One novel heterozygous missense (c.C667G, p.R223G) inherited from asymptomatic mother mosaic located highly conserved fragment exon 2. other synonymous (c.C348T, p.G116G) 1,...
INTRODUCTION: The tumor cells could escape from the immune elimination through immunoediting mechanisms including generation of immunosuppressive or immunoregulative cells. By contrast, allograft transplantation activate system and induce a strong allogenic response. aim this study was to investigate efficacy skin in inhibition growth activation METHODS: Full-thickness performed C57BL/6 (H-2b) donors BALB/c (H-2d) recipients that were receiving subcutaneous injection isogenic CT26 colon...
Osteogenesis imperfecta (OI) is a congenital bone dysplasia mainly caused by either defective production or assembly of type I collagen. The skeletal phenotypes especially fractures are often seen in OI adolescents. Studies have found that an increased number osteoclasts and excessive resorption existed collagen-related OI, which has not been well understood. Emerging evidence suggested inflammation may be associated with OI. We speculated the marrow (BM) niche had similar inflammatory...
To study the effectiveness of facial meticulous fat grafting by granules injection asistor.Between January and August 2015, 46 patients received autologous for rejuvenation. There were 7 males 39 females, aged 21-65 years (mean, 34 years). Firstly, faces divided into 10 cosmetic zonations according to aesthetic criteria, then was carried out asistor. The filled 1, 2, 3, 4, 5, 6, 7, 8, 9 in 10, 4 cases respectively; injected amount 2-110 mL 47 mL).The swelling period from 5 15 days after...