A5048154007- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Dental Research and COVID-19
- Laser Applications in Dentistry and Medicine
- Dental Anxiety and Anesthesia Techniques
- Oral microbiology and periodontitis research
- Immune cells in cancer
- Oral and Maxillofacial Pathology
- Acute Lymphoblastic Leukemia research
- Dental Erosion and Treatment
- Healthcare Regulation
- Bone Tumor Diagnosis and Treatments
- T-cell and Retrovirus Studies
- Immunotherapy and Immune Responses
- Chronic Lymphocytic Leukemia Research
- PI3K/AKT/mTOR signaling in cancer
- Hedgehog Signaling Pathway Studies
- Oral and gingival health research
- Cardiovascular Disease and Adiposity
- Dental Radiography and Imaging
- Peptidase Inhibition and Analysis
- Oral Health Pathology and Treatment
- Photodynamic Therapy Research Studies
- Ferroptosis and cancer prognosis
Massachusetts General Hospital
2013-2022
Universidade Estadual da Paraíba
2013-2021
Harvard University
2011-2021
Alex's Lemonade Stand Foundation
2015
National Foundation for Cancer Research
2015
Indiana University School of Medicine
2007-2011
Dana-Farber Cancer Institute
2004-2011
Indiana University – Purdue University Indianapolis
2007-2011
Indiana University Health
2011
Significance Improving survival of patients with glioblastoma (GBM) using antiangiogenic therapy remains a challenge. In this study we show that dual blockade angiopoietin-2 and vascular endothelial growth factor delays tumor enhances benefits through reprogramming tumor-associated macrophages toward an antitumor phenotype as well by pruning immature vessels. The immunomodulatory potential supports clinical testing approach for GBM other immunotherapeutic approaches such checkpoint blockers.
Glioblastomas (GBMs) rapidly become refractory to anti-VEGF therapies. We previously demonstrated that ectopic overexpression of angiopoietin-2 (Ang-2) compromises the benefits receptor (VEGFR) treatment in murine GBM models and circulating Ang-2 levels patients rebound after an initial decrease following cediranib (a pan-VEGFR tyrosine kinase inhibitor) administration. Here we tested whether dual inhibition VEGFR/Ang-2 could improve survival two orthotopic GBM, Gl261 U87. Dual therapy using...
Abstract Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma (GBM) trials. Here, we show that regulatory T (Treg) cells play a key role GBM resistance to ICBs experimental gliomas. Targeting glucocorticoid-induced TNFR-related receptor (GITR) Treg using an agonistic antibody (αGITR) promotes CD4 cell differentiation into effector cells, alleviates cell-mediated suppression of anti-tumor immune response, and induces potent GBM. The reprogrammed GBM-infiltrating express...
Efficient generation of competent vasculogenic cells is a critical challenge human induced pluripotent stem (hiPS) cell-based regenerative medicine. Biologically relevant systems to assess functionality the engineered vessels in vivo are equally important for such development. Here, we report unique approach derivation endothelial precursor from hiPS using triple combination selection markers—CD34, neuropilin 1, and kinase insert domain-containing receptor—and an efficient 2D culture system...
Abstract Purpose: Obesity promotes pancreatic and breast cancer progression via mechanisms that are poorly understood. Although obesity is associated with increased systemic levels of placental growth factor (PlGF), the role PlGF in obesity-induced tumor not known. its receptor VEGFR-1 have been shown to modulate angiogenesis promote tumor-associated macrophage (TAM) recruitment activity. Here, we hypothesized activity PlGF/VEGFR-1 signaling mediates by augmenting TAM recruitment/activity....
Gastric cancer is a prevalent tumor that usually detected at an advanced metastatic stage. Currently, standard therapies are mostly ineffective. Here, we report Glypican-3 (GPC3) absent in invasive tumors and lymph nodes, particular aggressive highly disseminated signet ring cell carcinomas. We demonstrate loss of GPC3 correlates with poor overall survival patients. Moreover, show absence causes up-regulation MAPK/FoxM1 signaling blockade this pathway alters cellular invasion. An inverse...
Objective: To evaluate, in vitro, the effect of photodynamic therapy (PDT) compared to laser and use a photosensitizer alone. Material Methods: The following therapies were used: PDT, For methylene blue (MB) at different concentrations red InGaAlP 660nm used. low-power (LPL) alone, 660 nm infrared AsGaAl, 830 nm, both continuous emission Standard ATCC strains Staphylococcus aureus (S. aureus), Escherichia coli (E. coli) Pseudomonas aeruginosa (P. aeruginosa) species antibacterial PDT was...
Oral paresthesia is a localized condition of sensory abnormality that occurs in the presence injury one nerves region after certain dental procedures.The aim this study was to present case report patient who received low-level laser therapy as treatment for inferior alveolar nerve due mandibular third molar extraction surgery.A 25-year-old female reported lack sensitivity 6 months various regions bucomaxillofacial complex surgery.Laser (808 ± 10nm, 100 mW, 3J per point and 30 seconds point)...
To evaluate the tooth enamel surface morphology after action of 35% hydrogen peroxide with and without LED activation.70 bovine incisors an 4x4x3 mm were used, prepared for reading superficial microhardness roughness. Specimens randomly distributed divided into 7 experimental groups (n = 10); G1 artificial saliva; G2 HP - 2 sessions (3x15´); G3 Phosphoric Acid + 3 G4 (3x15´) blue LED; G5 green G6 (3x20´) violet G7 Violet (3x20´). The results analyzed by Anova, Wilcoxon, Dunnett Tukey tests...
Introdução: A periodontia é uma especialidade odontológica que visa promover a saúde dos tecidos periodontais através do controle agentes etiológicos das periodontopatogenias, os microrganismos. Apesar da raspagem e alisamento coronoradicular consistir em um tratamento mecânico bastante utilizado, tal terapia não consegue proporcionar o patógenos nas áreas de difíceis instrumentação, motivo pelo qual torna-se necessário utilização terapias complementares reduzam redutos bacterianos locais...
Introdução: A endodontia é uma especialidade odontológica que visa promover a saúde dentária por meio da eliminação de micro-organismos capazes causar agressões pulpares. terapia fotodinâmica antimicrobiana, apresenta-se como alternativa coadjuvante ao tratamento endodôntico convencional para dos resistentes preparo-químico-mecânico. Objetivo: Explorar literatura dando enfoque mecanismo ação e aplicabilidade aPDT na do Enterococcus faecalis. Material método: Realizou-se revisão conduzida...
A cicatrização de feridas é um processo complexo, composto por vários estágios interdependentes e simultâneos com o objetivo reparar tecido e, dentre os métodos que utilizados, a laserterapia apresenta efeitos estimuladores biológicos regenerativos. O dessa revisão compreender mecanismo ação da na reparação tecidual mais especificamente, angiogênese. Foi realizada uma pesquisa bibliográfica nas bases dados PUBMED, LILACS SCIELO sobre assunto, utilizando as seguintes palavras-chave:...
Abstract OBJECTIVE: We aimed to enhance the efficacy of anti-VEGF therapy in glioblastoma (GBM) through additional inhibition Angiopoietin-2 (Ang-2), a potential mediator resistance antiangiogenic using VEGF inhibition. INTRODUCTION: Glioblastoma is uniformly lethal primary brain tumor affecting more than 12.000 patients every year US alone. The standard regimen for this highly angiogenic entity comprises maximal safe resection and chemoradiation with temozolomide. addition (anti-VEGF) care...
AbstractThe aim of this study was to investigate the Brazilian scientific production about acupuncture in dentistry, outlining profile works subject presented at Meetings Society Dental Research (SBPqO). It a cross-sectional study, with quantitative approach, based on secondary data. An analysis all abstracts last ten SBPqO (2009-2018) published annals event carried out. For research location term "acupuntura" or "acupuncture" among realized and following information collected: type...
A doença periodontal (DP) é um importante problema de Saúde Pública sem tratamento eficiente, apesar das diversas modalidades disponíveis. fototerapia e a fitoterapia representam opções terapêuticas. Dentre os fitoterápicos usados em Periodontia, Curcuma Longa apresenta propriedades anti-inflamatórias, anti-bacterianas, antioxidantes adstringentes com melhora significativa na saúde gengival. Dessa forma, uma alternativa antibacteriana potencial promissora por seus efeitos diretos ou atuar...
Abstract OBJECTIVE: Here we aimed to overcome resistance anti-VEGF therapy in glioblastoma (GBM), the most common and aggressive adult primary brain tumor. INTRODUCTION: Current standard of care, including chemo-radiation, confers modest overall survival benefits less than 1.5 years patients. GBMs are highly dependent on angiogenesis, is a promising approach prolong survival. While prolongs progression-free GBM, patients rapidly become refractory not increased. We previously demonstrated...