A5107306732- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- ECG Monitoring and Analysis
- Immunotherapy and Immune Responses
- Analog and Mixed-Signal Circuit Design
- PARP inhibition in cancer therapy
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
- Cancer Research and Treatments
- Lymphoma Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- Acupuncture Treatment Research Studies
- Viral-associated cancers and disorders
- Glioma Diagnosis and Treatment
- Wireless Body Area Networks
- EEG and Brain-Computer Interfaces
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Diverse Topics in Contemporary Research
- Sugarcane Cultivation and Processing
- Atherosclerosis and Cardiovascular Diseases
- Immune cells in cancer
- Diverse Approaches in Healthcare and Education Studies
- Immunodeficiency and Autoimmune Disorders
Dana-Farber Cancer Institute
2011-2023
Harvard University
2008-2022
International St. Mary's Hospital
2014-2021
Catholic Kwandong University
2021
KU Leuven
2010-2013
Inje University
2013
IMEC
2010-2013
Yonsei University
2009
Korea Advanced Institute of Science and Technology
2008-2009
Seoul National University Dental Hospital
2008
T helper type 17 (TH17) cells are highly proinflammatory effector that characterized by the production of high amounts IL-17A, IL-17F, IL-21, and IL-22. Furthermore, TH17 have been associated with a number autoimmune diseases. However, it is not clear whether can also serve as effective cells. Here we show function B-cell helpers in they only induce strong proliferative response B vitro but trigger antibody class switch recombination vivo. Transfer into WT or T-cell receptor α–deficient...
PARP inhibitors have shown promising clinical activities for patients with BRCA mutations and are changing the landscape of ovarian cancer treatment. However, therapeutic mechanisms action inhibition in interaction tumors tumor microenvironment host immune system remain unclear. We find that by olaparib triggers robust local systemic antitumor immunity involving both adaptive innate responses through a STING-dependent response mice bearing Brca1-deficient tumors. This effect is further...
How T cells maintain their identity Although best known for pathogen-fighting prowess, lymphocytes also ensure that the immune response does not run amok. A subset of called regulatory (T regs ) performs this function by, example, making sure only attack pathogens and self. can exhibit plasticity in functions face an inflammatory stimulus. Kim et al. sought to identify molecules stable maintenance . Using genetically modified mice, they found both CD4 + CD8 require transcription factor...
Prolonged perioperative delivery of immunotherapy prevents local tumor recurrence and eliminates established spontaneous metastases.
PARP inhibitors (PARPi) have drastically changed the treatment landscape of advanced ovarian tumors with BRCA mutations. However, impact this class in patients BRCA-mutant breast cancer is relatively modest. Using a syngeneic genetically-engineered mouse model tumor driven by Brca1 deficiency, we show that tumor-associated macrophages (TAMs) blunt PARPi efficacy both vivo and vitro. Mechanistically, BRCA1-deficient cells induce pro-tumor polarization TAMs, which turn suppress PARPi-elicited...
Abstract Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma (GBM) trials. Here, we show that regulatory T (Treg) cells play a key role GBM resistance to ICBs experimental gliomas. Targeting glucocorticoid-induced TNFR-related receptor (GITR) Treg using an agonistic antibody (αGITR) promotes CD4 cell differentiation into effector cells, alleviates cell-mediated suppression of anti-tumor immune response, and induces potent GBM. The reprogrammed GBM-infiltrating express...
Background Poly (ADP-ribose) polymerase (PARP) inhibition (PARPi) has demonstrated potent therapeutic efficacy in patients with BRCA-mutant ovarian cancer. However, acquired resistance to PARPi remains a major challenge the clinic. Methods PARPi-resistant cancer mouse models were generated by long-term treatment of olaparib syngeneic Brca1-deficient tumors. Signal transducer and activator transcription 3 (STAT3)-mediated immunosuppression was investigated vitro co-culture experiments vivo...
Osteopontin (Opn) contributes to diverse biological processes that include immune responses, vascularization, and bone formation. Until recently, studies describing the activities of Opn have focused on cytokine-like properties secreted protein. Here, we show alternative translation a single mRNA species generates intracellular isoform. Utilization 5' canonical start site protein includes an N-terminal signal sequence allowing targeting secretory vesicles cytokine secretion, whereas usage...
It has been reported that retinoic acid (RA) enhances regulatory T (T reg) cell conversion by inhibiting the secretion of cytokines interfere with conversion. This report shows these conclusions provide a partial explanation at best. First, RA not only interfered cytokine but also ability to inhibit reg naive cells. Furthermore, enhanced even in absence inhibitory cytokines. The latter effect depended on receptor α (RARα) did require Smad3, despite fact Smad3 expression. RARα1 isoform was...
Abstract Mesenchymal stem cells (MSCs) therapy has limitations due to the poor viability of MSCs after cell transplantation. Integrin-mediated adhesion is a prerequisite for survival. As novel anti-death strategy improve survival in infarcted heart, were genetically modified overexpress integrin-linked kinase (ILK). The rate ILK-transfected (ILK-MSCs) was augmented by about 1.5-fold and phosphorylation ERK1/2 Akt ILK-MSCs increased three twofold, respectively. demonstrated an increase...
Significance Epstein–Barr virus (EBV) drives human B cell proliferation and transformation, but also potent T surveillance. When surveillance fails, EBV-driven malignancies arise. cells can be stimulated/expanded on EBV-transformed for adoptive therapy. Clinical data point to the therapeutic importance of CD4 cells, perhaps through direct cytotoxicity; mechanism underlying such an activity remains unknown. Previous studies show that signaling by EBV oncoprotein LMP1 enhances antigen...
A low-power analog signal processing IC is presented for the heart rhythm analysis. The ASIC features 3 identical, but independent intra-ECG readout channels each equipping an QRS feature extractor consumption and fast diagnosis of fatal case. 16-level digitized sine-wave synthesizer together with a synchronous circuit can measure bio-impedance in range 0.1-4.4 kΩ 33 mΩ(rms) resolution higher than 97% accuracy. proposed 25 mm² consumes only 13 μA from 2.2 V. It highly integrated solution...
Significance Regulatory T cells (Tregs) play a critical role in inflammatory, autoimmune, and antitumor immune responses. Increased expression of transcription factor Helios by tumor-infiltrating Tregs can enhance immune-suppressive activity, while deletion promotes an effector helper (Th) cell phenotype that contribute to the host response. We report chronic inflammatory conditions tumors induce Helios-deficient express increased levels genes associated with activation Th differentiation....
A motion artifact removal method with a two-stage cascade LMS adaptive filter is proposed for an ambulatory ECG monitoring system. The first stage consisting of analog feedback prevents the signal saturation to reduce input dynamic range. An step-size algorithm introduced and employed second stage. can achieve fast convergence track large sudden quickly, while preventing distortion component. filtering performance evaluated by heart beat detection, measured sensitivity (Se) positive...
Significance There is increasing evidence that CD8 + regulatory T cells (CD8 Treg) can modulate the immune response in context of autoimmune disease, infection, and cancer. Here we asked whether this mechanism might control host to transplanted heart allografts. We report Treg recognize Qa-1, murine homolog HLA-E, strongly inhibits production antibodies specific for donor organ. Since antidonor currently a major barrier successful transplantation, identification Qa-1/HLA-E-dependent pathway...
Abstract d ‐Tagatose was continuously produced using thermostable l ‐arabinose isomerase immobilized in alginate with ‐galactose solution a packed‐bed bioreactor. Bead size, L/D (length/diameter) of reactor, dilution rate, total loaded enzyme amount, and substrate concentration were found to be optimal at 0.8 mm, 520/7 0.375 h ‐ 1 , 5.65 units, 300 g/L, respectively. Under these conditions, the bioreactor about 145 g/L tagatose an average productivity 54 g tagatose/L·h conversion yield 48%...
A low cost quadratic level compression algorithm is proposed for body sensor network system. The reduces the encoding delay and hardware cost, while maintaining reconstructed signal quality. determined by mean deviation value used to preserve critical information with high ratio. overall CR 8.4:1, PRD 0.897% rate 6.4 Mbps. 16-bit node processor designed, which supports algorithm. consumes 0.56 nJ/bit at 1 V supply voltage MHz operating frequency in 0.25-microm CMOS process.
Background: Carcinoma-associated fibroblasts (CAFs) contribute to carcinogenesis and cancer progression, although their origin role remain unclear.We recently identified investigated the in situ identity implications of gastric submucosa-resident mesenchymal stem cells (GS-MSCs) progression carcinogenesis.Methods: We isolated GS-MSCs from submucosa using hydrogel-supported organ culture defined identity.Isolated were assessed vitro by immunophenotype mesengenic multipotency.Reciprocal...
A wireless ECG monitoring system is presented that able to perform high-quality signal acquisition, beat detection, and real time of skin-electrode impedance which can be used monitor the presence motion artefacts. The whole consumes only 170μW while performing local detection. detection algorithm was verified against MIT-BIH arrhythmia database obtains a median sensitivity 99.74% positive predictivity 99.87%. validated using applied signals at varying noise ratio as well on human volunteers.