A5100735091- Acute Myeloid Leukemia Research
- Corneal surgery and disorders
- Hematopoietic Stem Cell Transplantation
- RNA Research and Splicing
- MicroRNA in disease regulation
- Phagocytosis and Immune Regulation
- Glaucoma and retinal disorders
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Neuroblastoma Research and Treatments
- Intraocular Surgery and Lenses
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Corneal Surgery and Treatments
- Immune Cell Function and Interaction
- Ophthalmology and Visual Impairment Studies
- Cancer, Hypoxia, and Metabolism
- CAR-T cell therapy research
- Epigenetics and DNA Methylation
- Vitamin C and Antioxidants Research
- Retinoids in leukemia and cellular processes
- Vitamin D Research Studies
- Lung Cancer Research Studies
- Adipose Tissue and Metabolism
- PI3K/AKT/mTOR signaling in cancer
Harvard University
2023-2025
Dana-Farber Cancer Institute
2023-2025
Jiangnan University
2025
First Affiliated Hospital of Guangdong Pharmaceutical University
2024
Institute of Automation
2024
Ministry of Agriculture and Rural Affairs
2023
First Affiliated Hospital of Xinjiang Medical University
2015-2023
Xinjiang Medical University
2015-2023
Sichuan Agricultural University
2020-2023
Shanghai Jiao Tong University
2016-2022
Constitutive photomorphogenesis 9 signalosome (CSN) consists of a total eight subunits (CSN1-CSN8) in mammalian cells. CSN6 may promote carcinogenesis by positively regulating v‑myc avian myelocytomatosis viral oncogene homolog (Myc) and MDM2 proto‑oncogene stability, is regarded as potential target for cancer therapy. Quercetin has substantial anticancer effect on various human The present study investigated the effects quercetin HT-29 colorectal cell viability, apoptosis cycle arrest using...
Abstract Background Increasing evidence shows that tRNA‐derived small RNAs (tsRNAs) are not only by‐products of transfer RNAs, but they participate in numerous cellular metabolic processes. However, the role tsRNAs skeletal muscle regeneration remains unknown. Methods Small RNA sequencing revealed relationship between and injury. The dynamic expression level 5'tiRNA‐Gly after injury was confirmed by real‐time quantitative PCR (q‐PCR). In addition, q‐PCR, flow cytometry,...
The role of autotransplantation in end-stage hepatic alveolar echinococcosis (AE) is unclear. We aimed to present our 15-case experience and propose selection criteria for autotransplantation. All patients were considered have unresectable AE by conventional resection due critical invasion retrohepatic vena cava, hepatocaval region along with three veins, the tertiary portal arterial branches. successfully underwent ex vivo extended right hepatectomy without intraoperative mortality. median...
Certain secretory proteins are known to be critical for maintaining the stemness of stem cells through autocrine signaling. However, processes underlying biogenesis, maturation, and secretion these remain largely unknown. Here we demonstrate that many produced by hematopoietic (HSCs) undergo exosomal maturation release is controlled vacuolar protein sorting 33b (VPS33B). Deletion VPS33B in either mouse or human HSCs resulted impaired exosome as well loss stemness. Additionally, deficiency...
Background There have been limited comparative data regarding the investigations on pulmonary and respiratory muscle function in patients with different parkinsonism disorders such as Parkinson’s disease (PD) multiple system atrophy (MSA) versus normal elderly. The present study is aiming to characterize performance of strength PD MSA, investigate association severity motor symptoms duration. Methods Pulmonary tests were performed 30 PD, 27 MSA well 20 age-, sex-, height-, weight-matched...
In addition to acting as building blocks for biosynthesis, amino acids might serve signaling regulators in various physiological and pathological processes. However, it remains unknown whether acid levels affect the activities of hematopoietic stem cells (HSCs). By using a genetically encoded fluorescent sensor intracellular branched-chain (BCAAs), we could monitor dynamics BCAA metabolism HSCs. A mitochondrial-targeted 2C-type Ser/Thr protein phosphatase (PPM1K) promotes catabolism BCAAs...
Leukemia-initiating cells (LICs) are responsible for the initiation, development, and relapse of leukemia. The identification novel therapeutic LIC targets is critical to curing In this report, we reveal that junctional adhesion molecule 3 (JAM3) highly enriched in both mouse human LICs. Leukemogenesis almost completely abrogated upon Jam3 deletion during serial transplantations an MLL-AF9–induced murine acute myeloid leukemia model. contrast, does not affect functions hematopoietic stem...
B cell acute lymphoid leukemia uses the mitochondrial respiration as main energy source that enhances drug resistance.
Abstract Background HELLP (Hemolysis, elevated liver enzymes, and low platelets) syndrome is a dangerous obstetric condition that in great need of simple inexpensive non-invasive early predictors, but it has been poorly studied. This study was conducted to investigate the predictive role serum gamma-glutamyl transpeptidase platelet ratio (GPR) during pregnancy its adverse outcomes. Methods retrospective tertiary hospital. One hundred parturients were allocated into two groups: group ( n =...
Abstract Background The inactivation of c-Jun N-terminal kinase (JNK) is associated with anti-apoptotic and anti-inflammatory effects in cerebral ischemia, which can be induced by an imbalance between upstream phosphatases kinases. Result Mitogen-activated protein phosphatase 7 (MKP-7) was upregulated significantly at 4 h reperfusion postischemia rat hippocampi. By administration cycloheximide or siRNA against mitogen-activated a model ischemia/reperfusion, obvious enhancement JNK activity...
Abstract Mutations of vacuolar protein sorting‐associated 33b (VPS33B) cause arthrogryposis, renal dysfunction, and cholestasis syndrome, a lack platelet α‐granules in the affected patients. Conditional Vps33b knockout mice were developed to investigate function(s) α‐granule formation. We found that early embryonic deletion was lethal. PF4‐Cre‐driven megakaryocyte‐targeted gene greatly diminished expression platelets, but had no effect on formation content. Tamoxifen‐induced, haematopoietic...
Targeting leukemia initiating cells is considered to be an effective way cure leukemia, for which it critical identify novel therapeutic targets. Herein, we demonstrate that CD244, was initially reported as a key regulator natural killer cells, highly expressed on both mouse and human cells. Upon CD244 knockdown, cell lines primary have markedly impaired proliferation abilities in vitro vivo. Interestingly, the repopulation ability of hematopoietic stem not upon knockdown. Using...
CD274 (programmed death ligand 1, also known as B7H1) is expressed in both solid tumors and hematologic malignancies of critical importance for the escape tumor cells from immune surveillance by inhibiting T cell function via its receptor, programmed 1 (PD-1). Increasing evidence indicates that functional monoclonal antibodies may potently enhance antitumor effect many cancers. However, role leukemia-initiating (LICs) remains largely unknown. We established an MLL-AF9-induced acute myeloid...
Epigenetic factors, including non-coding RNA regulation, play a vital role in the development of obesity and have been well researched. Transfer RNA-derived small (tsRNA) is class proven to be involved various aspects mammalian biology. Here we take pigs as model for research use tsRNA-seq investigate difference tsRNA expression subcutaneous adipose tissue obese lean elucidate development. A total 482 tsRNAs were identified pig tissue, which 123 significantly differentially accumulated...
der(1;7)(q10;p10).We observed that MDS patients with der(1;7) (q10;p10) present male predominance and have a better outcome than the -7/del(7q) group (Supplementary Table 4).Our findings revealed mutation spectrum of der(1;7)(q10; p10) was different from -7/del(7q).We demonstrate for first time, to our knowledge, is associated high frequency mutations in RUNX1.Further studies are needed clarify whether how RUNX1 contribute pathogenesis this subtype.
Targeting leukemia-initiating cells (LICs) is the key to eradicating leukemia and preventing its relapse. Recent studies have indicated that metabolic regulation may play a critical role in maintenance of stemness LICs, although detailed mechanisms are poorly understood. Herein, we provide intriguing evidence showing glucose-responsive transcription factor, carbohydrate responsive element binding protein (ChREBP), served as tumor suppressor rather than an oncogene, previously described,...
Human umbilical cord mesenchymal stem cells (hUC‑MSCs) hold great potential in the search for therapies to treat refractory diseases, including rheumatoid arthritis (RA), due their regenerative ability and extensive source. However, role of hUC‑MSCs vivo repair mechanisms RA remain be fully elucidated. The present study aimed determine whether exert immunomodulatory effects have anti‑inflammatory capabilities treatment embolisms. Following transplantation into collagen type Ⅱ‑induced...