A5102770082- Immune cells in cancer
- Immune Response and Inflammation
- NF-κB Signaling Pathways
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- IL-33, ST2, and ILC Pathways
- Acute Myeloid Leukemia Research
- Neonatal Respiratory Health Research
- Pulmonary Hypertension Research and Treatments
- Eosinophilic Esophagitis
- Immune Cell Function and Interaction
- Urinary and Genital Oncology Studies
- Nitric Oxide and Endothelin Effects
- Vascular Malformations and Hemangiomas
- Phagocytosis and Immune Regulation
- Chalcogenide Semiconductor Thin Films
- Cardiac Ischemia and Reperfusion
- Advanced Semiconductor Detectors and Materials
- Cardiac electrophysiology and arrhythmias
- Statistical Methods in Clinical Trials
- Eosinophilic Disorders and Syndromes
- RNA modifications and cancer
- Renal function and acid-base balance
- interferon and immune responses
- MicroRNA in disease regulation
- Prostate Cancer Diagnosis and Treatment
Shanghai Jiao Tong University
2017-2025
Kunming Children's Hospital
2023-2024
Kunming Medical University
2023
Tongren Hospital
2017
Harbin Medical University
2013-2014
Alberta Innovates
2012
Alveolar macrophages (AMs) are specialized tissue-resident that orchestrate the immune response in allergic inflammation and asthma. However, what signals direct AMs to cross talk with other cells remains unclear. Here, we report autocrine motility factor receptor (AMFR), an endoplasmic reticulum–resident E3 ubiquitin ligase, is upregulated of asthma critical for this condition. AMFR deficiency significantly decreased allergy-induced T helper 2 (Th2) eosinophilic inflammation, less...
Inflammatory bowel disease (IBD) is a formidable due to its complex pathogenesis. Macrophages, as major immune cell population in IBD, are crucial for gut homeostasis. However, it still unveiled how macrophages modulate IBD. Here, we found that LIM domain only 7 (LMO7) was downregulated pro-inflammatory macrophages, and LMO7 directly degraded 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) through K48-mediated ubiquitination macrophages. As an enzyme regulates glycolysis,...
MAPK-activated protein kinase 2 (MK2) plays a critical role in the development of inflammation. However, modulatory mechanisms macrophage activation and acute lung injury (ALI) have not been completely defined. Here, we reported that MK2-deficient mice (MK2-/-) protected against sepsis-induced ALI. In response to lipopolysaccharide (LPS) challenge, MK2-/- myeloid cell-specific MK2 conditional knockout (MK2Lyz2-KO) exhibited attenuated inflammatory response, especially producing fewer amounts...
Lung infections are major causes of acute lung injury (ALI), with limited effective treatment available. Tumor necrosis factor receptor-associated 6 (TRAF6) is an essential adaptor regulating Toll-like receptors (TLRs). We recently identified Cullin-5 (Cul-5) as a prominent component in the regulation TRAF6 polyubiquitination, but its physiological significance ALI has not been explored. In this study, we investigated potential role Cul-5 using mice receiving intratracheal instillation LPS....
Abstract This paper presents a simulation study on the operational parameters of ES-SAGD process based an lab experiment. A numerical model that incorporated measured data key physical properties was validated by detailed history matching experiment with n-hexane as solvent. used to evaluate performance different operating strategies. The results indicate oil rate lifting from hexane injection is significant in early stage but becomes less effective later process. Improved solvent efficiency...
Pulmonary fibrosis is a group of life-threatening diseases with limited therapeutic options. The involvement cannabinoid type 1 receptors (CB1R) has been indicated in fibrotic diseases, but whether or not the activation CB1R can be benefit for treatment controversial. In this study, we investigated effects arachidonoylcyclopropylamide (ACPA), as selective agonist, on bleomycin (BLM)-induced pulmonary fibrosis. We showed that ACPA significantly improved survival rate BLM-treated mice,...
der(1;7)(q10;p10).We observed that MDS patients with der(1;7) (q10;p10) present male predominance and have a better outcome than the -7/del(7q) group (Supplementary Table 4).Our findings revealed mutation spectrum of der(1;7)(q10; p10) was different from -7/del(7q).We demonstrate for first time, to our knowledge, is associated high frequency mutations in RUNX1.Further studies are needed clarify whether how RUNX1 contribute pathogenesis this subtype.
Abstract Prostate Cancer (PC) is the most common male nonskin tumour in world, and diagnosed patients are over 65 years old. The main treatment for PC includes surgical nonsurgical treatment. Currently, nonsurgically treated elderly patients, few studies have evaluated their prognostic factors. Our aim was to construct a nomogram that could predict cancer-specific survival (CSS) assess prognosis-related independent risk Patient information obtained from Surveillance, Epidemiology End Results...
Background/Aims: Copper is an essential trace element for normal cellular function and contributes to critical physiological or pathological processes. The aim of the study was investigate effects copper on vascular tone rat mesenteric artery compare noradrenaline (NA) high K+ induced vasoconstriction. Methods: arteries were isolated vessel measured by using multi wire myograph system in vitro. Blood pressure carotid rabbits data acquisition analysis vivo. Results: dose-dependently blunted...
Aim: Patients with muscle-invasive bladder cancer (MIBC) have a low survival rate, 5-year of approximately 45%, regardless the treatment received. The risk death within 5 years after radical cystectomy in patients MIBC remains as high 60%. Over 80% are over 65. Therefore, identifying prognostic correlates associated older could improve rates. In addition, radiotherapy and chemotherapy particularly important adjuvant treatments for undergoing cystectomy. this study aimed to find factors...
As a crucial member of the Interleukin-1 (IL-1) family, IL-33 plays an indispensable role in modulating inflammatory responses. Here, we developed effective anti-human monoclonal antibody (mAb) named 5H8. Importantly, have identified epitope (FVLHN) protein as recognition sequence for 5H8, which important mediating biological activity IL-33. We observed that 5H8 significantly suppressed IL-33-induced IL-6 expression bone marrow cells and mast dose-dependent manner vitro. Furthermore,...