A5017624106- Radiomics and Machine Learning in Medical Imaging
- Nanoplatforms for cancer theranostics
- Immune cells in cancer
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Thyroid Cancer Diagnosis and Treatment
- interferon and immune responses
- Cancer Genomics and Diagnostics
- Supramolecular Self-Assembly in Materials
- Nanoparticle-Based Drug Delivery
- Ubiquitin and proteasome pathways
- MRI in cancer diagnosis
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- Cancer Research and Treatments
- Wound Healing and Treatments
- AI in cancer detection
- Histone Deacetylase Inhibitors Research
- Bioinformatics and Genomic Networks
- Electrospun Nanofibers in Biomedical Applications
- Luminescence and Fluorescent Materials
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Northeastern University
2019-2025
Qingdao University
2024
Huashan Hospital
2017-2024
Fudan University
2006-2024
Fudan University Shanghai Cancer Center
2018-2024
Sun Yat-sen University
2006-2024
Shanghai Medical College of Fudan University
2019-2024
Qilu Hospital of Shandong University
2015-2024
Sun Yat-sen University Cancer Center
2021-2024
Minhang District Central Hospital
2013-2024
The propensity of the activated neutrophils to form extracellular traps (NETs) is demonstrated in multiple inflammatory conditions. In this study, we investigated roles NETs metastasis hepatocellular carcinoma (HCC) and further explored underlying mechanism how affect as well therapeutic value.The were isolated from blood human HCC patients used evaluate formation NETs. expression NET markers was detected tumor specimens. A LPS-induced model investigate role on metastasis. RNA-seq performed...
Metastatic breast cancer may be resistant to chemo-immunotherapy due the existence of stem cells (CSC). Also, control particle size and drug release a carrier for multidrug combination is key issue influencing therapy effect. Here, cocktail strategy reported, in which chemotherapy against both bulk tumor CSC immune checkpoint blockade are intergraded into one delivery system. The chemotherapeutic agent paclitaxel (PTX), anti-CSC thioridazine (THZ), PD-1/PD-L1 inhibitor HY19991 (HY) all...
Significance Critical micellization concentration (CMC) is an important design consideration for developing all supramolecular biomaterials, and in particular drug delivery systems. Once placed vivo setting, materials will start to dissociate into monomeric units, providing a means therapeutic release essential pathway clearance. This beneficial phenomenon could also lead premature degradation. Through the of series self-assembling prodrugs (SAPDs) various CMCs, we developed fundamental...
Our aim was to propose a preoperative computer-aided diagnosis scheme differentiate pancreatic serous cystic neoplasms from other neoplasms, providing supportive opinions for clinicians and avoiding overtreatment.In this retrospective study, 260 patients with neoplasm were included. Each patient underwent multidetector row computed tomography scan resection. In all, 200 constituted cross-validation cohort, 60 formed an independent validation cohort. Demographic information, clinical images...
Abstract Cytotoxic T lymphocyte (CTL) eliminates abnormal cells through target recognition‐triggered intracellular toxin delivery. Chimeric antigen receptor T‐cell improves cancer cell recognition of CTL, but its effectiveness and safety in solid tumor treatment are still hampered by poor infiltration, suppressive microenvironment, severe on‐target off‐tumor toxicity. Given the functionality challenges CTL therapy, herein, a CTL‐inspired nanovesicle (MPV) with membrane–derived shell...
ISG15 (ISG15 ubiquitin-like modifier), a protein, is one of the major type I IFN (interferon) effector systems. can be conjugated to target proteins (ISGylation) via stepwise action E1, E2, and E3 enzymes. Conjugated removed (deISGylated) from by USP18 (ubiquitin-specific peptidase 18). Here we investigated role deISGylation in regulating autophagy EGFR degradation cells treated with IFNs. We show that induced expression leads ISGylation BECN1 at Lys117, as well Lys263, Lys265, Lys266 which...
The purpose of this study was to assess the feasibility using CT differentiate malignant from benign lesions in patients with pathologically confirmed appendiceal mucoceles.CT scans 18 consecutively registered (11 men, seven women; age range, 21-78 years) mucocele were reviewed retrospectively. Patients classified into three groups according pathologic results: nonneoplastic (n = 3), mucinous cystadenoma 10), and cystadenocarcinoma 5). formed a group, constituted group. Two experienced...
Triple-negative breast cancer (TNBC) tumors are heterogeneous, with mesenchymal-like cells at their core and fast proliferating on the periphery. It is desirable beneficial to treat TNBC of different phenotypes most appropriate drugs. Here, we report a 78 nm, chlorin e6-, docetaxel-, anti-Twist siRNA-containing polymeric nanoparticle (CDTN) spatiotemporally specific activity when irradiated by light. Under conditions mimicking superficial tumor tissue sufficient light input, mainly killed...
Abstract Tumor‐associated macrophages (TAMs) are crucial components of the tumor microenvironment. They play vital roles in hepatocellular carcinoma (HCC) progression. However, interactions between TAMs and HCC cells have not been fully characterized. In this study, were induced using human monocytic cell line THP‐1 vitro to investigate their functions S100 calcium‐binding protein A9 (S100A9), an inflammatory microenvironment‐related secreted protein, was identified be significantly...
LUBAC-mediated linear ubiquitination plays a pivotal role in regulation of cell death and inflammatory pathways. Genetic deficiency LUBAC components leads to severe immune dysfunction or embryonic lethality. has been extensively studied for its mediating TNF signaling. However, Tnfr1 knockout is not able fully rescue the lethality deficiency, suggesting that may modify additional key cellular substrates promoting survival. GPx4 an important selenoprotein involved regulating redox homeostasis...
Abstract Current multi-analytes chips are limited with requiring numbers of sensors, complex synthesis and compounds screen. It is expected to develop new principles techniques achieve high-performance testing facile sensors. Here, we investigated the correlative multi-states properties a photochromic sensor (spirooxazine), which capable selective cross-reactive array for discriminated (11 metal ions) detection by just one sensing compound. The multi-testing performed in dark, ultraviolet or...
Stimulation of cells with TNFα leads to the formation TNF-R1 signaling complex (TNF-RSC) mediate downstream cellular fate decision. Activation TNF-RSC is modulated by different types ubiquitination and may lead cell death, including apoptosis necroptosis, in both RIPK1-dependent RIPK1-independent manners. Spata2 (spermatogenesis-associated 2) an adaptor protein recruited into modulate interaction between linear ubiquitin chain assembly (LUBAC) deubiquitinase CYLD (cylindromatosis). However,...
Many immune cells are capable of homing to sites disease and eradicating infections abnormal cells. However, their efficacy is usually down‐regulated in tumor microenvironments it difficult boost. It presumed that the anticancer activity can be improved by integrating an additional therapeutic modality such as chemotherapy into Here, Ly6C hi monocytes armed with paclitaxel (PTX)‐loading pH‐sensitive micelle (PM), termed PM@MC, prepared. The PM internalization does not significantly affect...
Polyetheretherketone (PEEK) is becoming an attractive surgical implant material in the biomedical field. However, its hydrophobicity and biological inertia have seriously hindered development field of biomaterials application clinic. In this work, a mixed modification approach surface structure chemical state was proposed to improve hydrophilicity bioactivity PEEK meanwhile endowed it with antimicrobial properties. First, effect acids nitric acid concentrated sulfuric different volume ratios...
Abstract Vaccines against SARS-CoV-2 have shown high efficacy, but immunocompromised participants were excluded from controlled clinical trials. We compared immune responses to the Pfizer/BioNTech mRNA vaccine in solid tumor patients (n=53) on active cytotoxic anti-cancer therapy a control cohort (n=50) as an observational study. Using live assays, neutralizing antibodies detected 67% and 80% of cancer after first second immunizations, respectively, with 3-fold increase median titers...
Alveolar macrophages (AMs) are specialized tissue-resident that orchestrate the immune response in allergic inflammation and asthma. However, what signals direct AMs to cross talk with other cells remains unclear. Here, we report autocrine motility factor receptor (AMFR), an endoplasmic reticulum–resident E3 ubiquitin ligase, is upregulated of asthma critical for this condition. AMFR deficiency significantly decreased allergy-induced T helper 2 (Th2) eosinophilic inflammation, less...
Abstract Background Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent malignancies worldwide characterized by unfavorable prognosis, high lymph node metastasis early recurrence. However, molecular events regulating HNSCC tumorigenesis remain poorly understood. Therefore, uncovering underlying mechanisms urgently needed to identify novel promising therapeutic targets for HNSCC. In this study, we aimed explore role pleckstrin‐2 (PLEK2) in tumorigenesis. Methods The...
Abstract Head neck squamous cell carcinoma (HNSCC) is one of the most common malignant tumors which ranks sixth incidence in world. Although treatments for HNSCC have improved significantly recent years, its recurrence rate and mortality remain high. Myosin genes been studied a variety tumors, however role has not elucidated. GSE58911 GSE30784 gene expression profile analysis were performed to detect dys-regulated myosin HNSCC. The Cancer Genome Atlas (TCGA) database was used verify study...
The electrocatalytic reduction of carbon dioxide (CO 2 ) and different nitrogenous substances has shown a broad prospect in replacing the traditional urea synthesis process, but there are still serious challenges in...